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31.
We have shown that dicyanogold(I), [Au(CN)(2)](-) is a common metabolite found in blood and urine samples of patients treated with different gold based drugs. Some patients have high levels of gold within their red blood cells (RBCs). Size exclusion and C18 reversed phase chromatography show that the majority of the gold in RBC lysates is bound to protein, but small molecules such as dicyanogold(I) and gold-glutathione complexes are also present. Dicyanogold incubation with red blood cells in vitro leads to a rapid and complete uptake of gold. This uptake is unaffected by DIDS, an inhibitor of the anion channel, but is blocked by the addition of external cyanide. Dicyanogold is also readily taken up by H9 cells, a continuous CD(4+) cell line. This uptake is significantly inhibited by N-ethylmaleimide, suggesting a requirement for sulfhydryl groups. Dicyanogold inhibits the replication of the AIDS virus, HIV, in a cell culture model. 相似文献
32.
Creep experiments were conducted on ice crystals in compression to investigate the effects of boundary conditions on a single-slip system deformed in plane strain. Friction at the platens of the deformation apparatus introduces a bending moment which causes a variation in the amount of lattice rotation across the specimen. This is shown to occur in mechanically constrained crystals observed through plane polarized light. Relieving the constraints and minimizing friction at the ice-platen contact leads to the widening of the sample near the specimen-platen interface and the production of tails symmetrically disposed about the longitudinal axis of the deformed crystals. This is interpreted to originate from a bending moment in the opposite sense from that obtained in the constrained crystals, resulting from a progressive increase in slip displacement towards the platens where the segments of the slip plane become shorter. When the crystal ends were constrained but allowed to move sideways, a simple shear regime was established in which lattice slip was concentrated in the centre of the crystal. 相似文献
33.
Baranwal Alok Kumar Sharma Shashibhushan Roy Sanjay Dhar Kundu Sumit 《Wireless Personal Communications》2022,124(2):1281-1296
Wireless Personal Communications - This paper proposes and analyses the power allocation coefficient normalization for successive interference cancellation in power-domain non-orthogonal multiple... 相似文献
34.
Engineering with Computers - The vibration and damping characteristics of carbon nanotubes reinforced (CNTR) skewed shell structure under a hygrothermal environment have been investigated using the... 相似文献
35.
T. K. Roy 《Journal of Failure Analysis and Prevention》2017,17(1):93-99
One of the important applications of high tensile steel grades is in wheel rims by the automotive industry. High tensile steel facilitates vehicle weight reduction under the ‘Go Green’ initiative. Along with weight reduction, in recent times, the surface quality requirement of steels for wheel rim applications has also gained a significant focus, and in many cases, it is becoming the cause of rejection at the customers’ processing line. It is known that owing to chemistry requirements such high strength steel grades generally show peritectic behavior during solidification and are prone to surface defects. Tata Steel India produces several wheel rim grades of varying strength levels. In one such high manganese and micro-alloyed peritectic steel grade, the rejection by the customer on account of surface defects was a major concern. The defects consisted of typical longitudinal cracks of varying dimensions along with the unique defects in transverse direction named tear marks on the surface of 100-mm-thick plates rolled from 215-mm-thick slab. In subsequent stages, these plates were processed into rim profiles through hot working by the wheel customer. The paper highlights how systematic study led to arrive at root causes and helped redesign steel chemistry to ensure zero rejection for surface quality without affecting mechanical property requirements. 相似文献
36.
Classical Cartesian domain decompositions for parallel lattice Boltzmann simulations of fluid flow through heterogeneous porous media are doomed to workload imbalance as the number of processors increases, thus leading to decreasing parallel performance. A one-lattice lattice Boltzmann method (LBM) implementation with vector data structure combined with even fluid node partitioning domain decomposition and fully-optimized data transfer layout is presented. It is found to provide nearly-optimal workload balance, lower memory usage and better computational performance than classical slice decomposition techniques using sparse matrix data structures. Predictive memory usage and parallel performance models are also established and observed to be in very good agreement with data corresponding to numerical fluid flow simulations performed through 3-dimensional packings of cylinders and polydisperse spheres. 相似文献
37.
This paper is an attempt to improve on the approximation. First author citations (Cf)≈Total citations (Ct) of an author's publications without the work of making the complete citation count under the author and all co-author names. Using the bibliographies of all faculty from each of four large departments: Physics, Chemistry, Materials Sciences, and Biosciences, in the same university, both first author and complete citation counts were made, care being taken to avoid the most common errors in such counts. It is shown that the function Cf·T/F (where T and F are the total number of papers and F those with subject author's name first) correlates strongly (>90%) with Ct. We find also that Ct correlates strongly with T. The data also may be used as one more line of evidence to obtain normalizing ratios for possible comparisons of productivityacross different disciplinary universes. A very tentative ratio from different studies would be 8 (Chem.)=4 (Physics)=2.5 (Mat. Sci.)=2 (Mathematics)=4.5 (Biophysics-Biochemistry). 相似文献
38.
Soft computing-based approaches have been developed to predict specific energy consumption and stability margin of a six-legged robot ascending and descending some gradient terrains. Three different neuro-fuzzy and one neural network-based approaches have been developed. The performances of these approaches are compared among themselves, through computer simulations. Genetic algorithm-tuned multiple adaptive neuro-fuzzy inference system is found to perform better than other three approaches for predicting both the outputs. This could be due to a more exhaustive search carried out by the genetic algorithm in comparison with back-propagation algorithm and the use of two separate adaptive neuro-fuzzy inference systems for two different outputs. A designer may use the developed soft computing-based approaches in order to predict specific energy consumption and stability margin of the robot for a set of input parameters, beforehand. 相似文献
39.
Non-linear finite element analyses of structures (such as beams) involve construction of weak solutions for the governing equations. While a weak approach weakens the differentiability requirements of the so-called shape functions, the governing equations are only satisfied in an integral sense and not point-wise, or, even path-wise. Moreover, use of a finite mesh leads to a stiffening of the numerical model. While strong solutions obtained through some of the existing mesh-free collocation methods overcomes some of these lacunae to an extent, the quality of the numerical solutions would be considerably improved if the computational algorithm were able to faithfully reproduce (or approximate or preserve) certain geometrical features of the response surfaces or manifolds. This paper takes the first step towards realizing this objective and proposes a multi-step transversal linearization (MTL) technique for a class of non-linear boundary value problems, which are treated as conditionally dynamical systems. Numerical explorations are performed, to a limited extent, through applications to large deflection analyses of planar beams with or without plastic deformations. 相似文献
40.
A successful attempt to grow carbon nanotubes (CNTs) by electrodeposition technique for the first time is reported here. Carbon nanotubes were grown on Si (001) substrate using acetonitrile (1% v/v) and water as electrolyte at an applied d.c. potential ∼20 V. The films were characterized by X-ray Diffraction (XRD), Scanning Electron Microscope (SEM), Raman, optical absorbance, Fourier Transform Infra Red spectroscopy (FTIR) and Electron Spin Resonance (ESR) measurements. The effect of magnetic field on the growth of nanotubes was studied critically. It was found that the presence of magnetic field during electro-deposition played a crucial role on the growth of carbon nanotubes and hence the electronic properties. Photoluminescence (PL) studies indicated band edge luminescence ∼0.72-0.83 eV. Field emission studies indicated lower turn-on voltage and higher current density for films deposited with magnetic field. 相似文献