Screening for diabetic retinopathy: the utility of nonmydriatic retinal photography in Egyptian adults

BACKGROUND AND OBJECTIVE: Drug resistance has become a major cause of treatment failure in patients with acute leukemia. P-glycoprotein (Pgp), which is associated with the multidrug resistance (MDR) phenotype, has been reported to be an important predictor of treatment outcome. The aim of this study was to analyze the value of Pgp expression in bone marrow or peripheral blood as a predictor of the response to remission induction chemotherapy as well as the duration of remission in patients with de novo acute myeloid leukemia (AML). DESIGN AND METHODS: We examined the expression of Pgp in 82 patients with de novo AML using an immunocytochemical assay with the C219 monoclonal antibody. RESULTS: Twenty-seven of the 82 patients (33%) were C219-positive in from 1% to 100% of their cells. Thirteen cases (16%) showed a positive reaction in more than 50% of the leukemic cells. Only hyperleukocytosis was significantly associated with higher expression of Pgp. Although 8 of the 13 cases (62%) with more than 50% of cells having Pgp expression were CD34-positive, this association was not statistically significant. A univariate analysis of resistance to induction therapy showed a significantly higher resistance rate in patients with increased Pgp expression (P = 0.01) as well as in those patients with decreased reactivity to myeloperoxidase. The multivariate analysis revealed the independent prognostic value of Pgp expression. C219 reactivity did not have an influence on remission duration. INTERPRETATION AND CONCLUSIONS: Our data indicate that P-glycoprotein expression is a reliable marker of resistance to induction treatment in patients with de novo AML.     

Inter-individual variability in Ca2+ signalling in platelets from healthy volunteers: effects of aspirin and relationship with expression of endomembrane Ca2+-ATPases

Increased Ca2+ signal generation may lead to hyperactivity of platelets and contribute to thrombotic complications. Using fura-2-loaded platelets from 51 healthy volunteers, high variability was detected in the Ca2+ responses evoked by the receptor agonists, thrombin and collagen, and the inhibitor of sarco/endoplasmic reticulum Ca2+-ATPases (SERCA), thapsigargin (Tg). Oral intake of 500mg aspirin reduced the magnitude of the Ca2+ responses, and lowered the intra-individual coefficients of variance of the responses by 50%. However, the corresponding inter-individual variance coefficients were only a little influenced by aspirin intake, pointing to subject-dependent factors in Ca2+ handling that are unrelated to thromboxane formation. With each agonist, 6-9% of the subjects had platelets with relatively high Ca2+ responses (> mean + SD) both before and after aspirin intake. In 90% (9/10) of these cases the high responsiveness was confirmed in platelets obtained 6-12 months later. The Tg- but not thrombin-induced Ca2+ responses correlated inversely with the expression levels of SERCA PL/IM 430 (SERCA-3b) in platelets. After aspirin intake, the Ca2+ responses with collagen but not thrombin correlated inversely with SERCA-2b expression. These results suggest that, in the absence of potentiating effects of thromboxane, (i) the amount of PL/IM 430-recognizable SERCA may control the Ca2+ signal when SERCA-2b is specifically inhibited (with Tg), and (ii) the expression of SERCA-2b determine the collagen- but not the thrombin-evoked Ca2+ signal. Accordingly, limited Ca2+-pumping activity by low expression of one of the SERCA isoforms is likely to be one of the factors resulting in increased platelet activity towards collagen or thapsigargin but not thrombin.     

High-output congestive heart failure following transjugular intrahepatic portal-systemic shunting

A hyperdynamic circulatory state with elevated cardiac output, decreased peripheral vascular resistance, and sodium retention occurs in patients with portal cirrhosis. Surgical portal-systemic shunts and transjugular intrahepatic portal-systemic shunts (TIPS) have been shown to worsen the high-output state in these patients. However, clinical evidence of high-output congestive heart failure has been reported only rarely to complicate cirrhosis. We describe a patient who developed high-output congestive heart failure with markedly elevated filling pressures after TIPS and had complete resolution of heart failure after liver transplantation.     

信息管理系统中的工作流技术研究与设计

介绍了工作流的应用背景,分析了某校教务系统中采用的工作流技术的原理和设计思想。提出可编辑、管理和监控的工作流模型,并重点介绍了工作流程运行机制。工作流技术使单位内部业务流程自动化,信息流转逐步实现无纸化。利用其图形化定义流程的功能,在办公流程越来越严谨的前提下,办公效率也大幅提高。某校在教务系统中运用了工作流技术,取得了良好的效果。     

最佳相位设计的MBE声码器语音合成

提出了一种基于最佳相位设计的语音合成技术,能够有效降低MBE声码器合成语音信号由于波形失衡而导致的饱和失真的概率.此外,为了保证合成滤波器的稳定性,对线谱频率(LSF)系数提取进行了优化.实验结果显示,合成语音信号波形近似平衡地分布在零幅度值的上下,语音听起来没有不舒服的感觉.实验结果表明,基于最佳相位设计的语音合成技术能够有效改善合成语音质量.     

A variational method for contour tracking via covariance matching

This paper presents a novel formulation for contour tracking.We model the second-order statistics of image regions and perform covariance matching under the variational level set framework.Specifically,covariance matrix is adopted as a visual object representation for partial differential equation(PDE) based contour tracking.Log-Euclidean calculus is used as a covariance distance metric instead of Euclidean distance which is unsuitable for measuring the similarities between covariance matrices,because the matrices typically lie on a non-Euclidean manifold.A novel image energy functional is formulated by minimizing the distance metric between the candidate object region and a given template,and maximizing the one between the background region and the template.The corresponding gradient flow is then derived according to a variational approach,enabling partial differential equations(PDEs) based contour tracking.Experiments on several challenging sequences prove the validity of the proposed method.     

火星探测器转移轨道的自主导航方法

本文针对转移轨道火星探测器对自主导航的迫切需求,提出了一种基于小行星和X射线脉冲星交互观测的自主导航方法,并结合工程任务对上述量测信息的获取方式和获取条件进行了研究,仿真结果表明,与单独基于小行星或单独基于X射线脉冲星观测的自主导航系统相比,该方法不仅可获得更高的导航精度,为转移轨道中途修正提供准确的轨道信息,且工程实现简单,是一种可行的转移轨道火星探测器自主导航方案,可为我国火星探测器自主导航系统的设计提供参考.     

Transit smart card data mining for passenger origin information extraction

The automated fare collection(AFC) system,also known as the transit smart card(SC) system,has gained more and more popularity among transit agencies worldwide.Compared with the conventional manual fare collection system,an AFC system has its inherent advantages in low labor cost and high efficiency for fare collection and transaction data archival.Although it is possible to collect highly valuable data from transit SC transactions,substantial efforts and methodologies are needed for extracting such data because most AFC systems are not initially designed for data collection.This is true especially for the Beijing AFC system,where a passenger’s boarding stop(origin) on a flat-rate bus is not recorded on the check-in scan.To extract passengers’ origin data from recorded SC transaction information,a Markov chain based Bayesian decision tree algorithm is developed in this study.Using the time invariance property of the Markov chain,the algorithm is further optimized and simplified to have a linear computational complexity.This algorithm is verified with transit vehicles equipped with global positioning system(GPS) data loggers.Our verification results demonstrated that the proposed algorithm is effective in extracting transit passengers’ origin information from SC transactions with a relatively high accuracy.Such transit origin data are highly valuable for transit system planning and route optimization.