System reliability-based design optimization and risk-based optimization: a benchmark example considering progressive collapse

System Reliability-Based Design Optimization (RBDO) considers a single system failure probability constraint. The formulation allows different failure modes to compete with each other. Very few methods and benchmark examples involving optimal design considering system behaviour with progressive failure can be found in the literature. In this article, the conventional System RBDO formulation is compared with a risk-based formulation. A benchmark example involving progressive failure of hyper-static truss is addressed. It is demonstrated that typical System RBDO formulations always lead to isostatic structures, since the formulation does not offer any incentive for the permanence of hyper-static members. In the risk-based formulation, failure costs are differentiated with respect to primary member failure, in hyper-static structures (existence of warning before eventual collapse), and failure of isostatic members (no warning). In this formulation, optimal designs also include hyper-static structures. Results presented herein are relevant in the modern context of robust design considering progressive collapse.     

Inverse analysis procedure to determine flow stress and friction data for finite element modeling of machining

This paper describes an inverse procedure to determine the constitutive constants and the friction conditions in the machining processes using Finite Elements (FE) simulations. In general, the FE modeling of machining processes is an effective tool to analyze the materials machinability under different cutting conditions. However, the use of reliable rheological and friction models represents the basis of a correct numerical investigation. The presented inverse procedure was based on the numerical results obtained using a commercial FE code and was developed considering a specific optimization problem, in which the objective functions that have to be minimized is the experimental/numerical error. This problem was performed by a routine developed in a commercial optimization software. In order to verify the goodness and the robustness of the methodology, it was applied on a Super Duplex Stainless Steel (SDSS) and on an Austenitic Stainless Steel (AUSS) orthogonal machining processes. This work, then, was focused on the identification of the Johnson-Cook (JC) coefficients (A,B,C, n and m) and on the calibration of a Coulomb friction model, in the specific cases of the SAF2507 SDSS and of an AISI 316 Based AUSS Alloy (AISI 316 ASBA). The identification phases were performed considering forces and temperatures experimental data, collected in two specific experimental tasks in which different orthogonal cutting tests were carried out under different cutting parameters conditions.     

Comments on “A novel dead time compensator for stable processes with long dead times” [Journal of Process Control 22 (2012) 612–625]

This short communication analyzes the results recently presented in the paper “On a novel dead time compensator for stable processes with long dead times” published in the Journal of Process Control. In the mentioned paper it is argued that the proposed strategy, called modified Smith predictor (MSP), gives better performance than the filtered Smith predictor (FSP) dead-time compensator for stable processes with dead time. In fact MSP has the same structure as FSP and only some specific tuning rules of the filters are proposed. Therefore, in this work some aspects of the comparative analysis and tuning rules presented in the referred paper are discussed to show that MSP is a particular case of FSP and that for some particular cases its tuning rule does not allow for a good closed-loop response. Some simulation case studies are used to illustrate these aspects.     

Reactor cavity cooling system (Rccs) experimental characterization

The development of a new concept for a high temperature gas cooled reactor is strictly correlated to the Reactor Cavity Cooling System (RCCS) design. This is the latest heat sink designed to ensure the cooling down of the vessel and other structural materials during an accident scenario. An experimental facility was built at Texas A&M to quantitatively analyze heat transfer phenomena and the air flow regime inside the reactor cavity. The thermal measurements were performed using 18 thermocouples mounted on the vessel surface, 8 on the external surface of one of the cooling pipes and 24 on a movable rack that captures the axial temperature profile inside the cavity. Flow regime measurements were performed with Particle Tracking Velocimetry techniques (PTV), using a high speed camera and spraying a special dust in the cavity for the tracking. The results demonstrate that the main heat transfer mode inside the cavity is the radiation (about 80%); also, they show the complexity of the flow regime inside the cavity due to natural circulation. The experimental conditions were a vessel surface temperature of about 300 °C heated at fixed power and different flow rates for the cooling pipes.     

The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer

Immunotherapy has improved patient survival in many types of cancer, but for prostate cancer, initial results with immunotherapy have been disappointing. Prostate cancer is considered an immunologically excluded or cold tumor, unable to generate an effective T-cell response against cancer cells. However, a small but significant percentage of patients do respond to immunotherapy, suggesting that some specific molecular subtypes of this tumor may have a better response to checkpoint inhibitors. Recent findings suggest that, in addition to their function as cancer genes, somatic mutations of PTEN, TP53, RB1, CDK12, and DNA repair, or specific activation of regulatory pathways, such as ETS or MYC, may also facilitate immune evasion of the host response against cancer. This review presents an update of recent discoveries about the role that the common somatic mutations can play in changing the tumor microenvironment and immune response against prostate cancer. We describe how detailed molecular genetic analyses of the tumor microenvironment of prostate cancer using mouse models and human tumors are providing new insights into the cell types and pathways mediating immune responses. These analyses are helping researchers to design drug combinations that are more likely to target the molecular and immunological pathways that underlie treatment failure.     

Ethanol steam reforming kinetics of a Pd–Ag membrane reactor

The ethanol steam reforming reaction carried out in a Pd-based tubular membrane reactor has been modelled via a finite element code. The model considers the membrane tube divided into finite volume elements where the mass balances for both lumen and shell sides are carried out accordingly to the reaction and permeation kinetics. Especially, a simplified “power law” has been applied for the reaction kinetics: the comparison with experimental data obtained by using three different kinds of catalyst (Ru, Pt and Ni based) permitted defining the coefficients of the kinetics expression as well as to validate the model. Based on the Damkohler–Peclet analysis, the optimization of the membrane reformer has been also approached.     

Hedgehog Signalling Modulates Immune Response and Protects against Experimental Autoimmune Encephalomyelitis

The Hedgehog (Hh) pathway is essential for the embryonic development and homeostatic maintenance of many adult tissues and organs. It has also been associated with some functions of the innate and adaptive immune system. However, its involvement in the immune response has not been well determined. Here we study the role of Hh signalling in the modulation of the immune response by using the Ptch-1-LacZ^+/− mouse model (hereinafter referred to as ptch^+/−), in which the hemizygous inactivation of Patched-1, the Hh receptor gene, causes the constitutive activation of Hh response genes. The in vitro TCR stimulation of spleen and lymph node (LN) T cells showed increased levels of Th2 cytokines (IL-4 and IL-10) in ptch^+/−cells compared to control cells from wild-type (wt) littermates, suggesting that the Th2 phenotype is favoured by Hh pathway activation. In addition, CD4⁺ cells secreted less IL-17, and the establishment of the Th1 phenotype was impaired in ptch^+/− mice. Consistently, in response to an inflammatory challenge by the induction of experimental autoimmune encephalomyelitis (EAE), ptch^+/− mice showed milder clinical scores and more minor spinal cord damage than wt mice. These results demonstrate a role for the Hh/ptch pathway in immune response modulation and highlight the usefulness of the ptch^+/− mouse model for the study of T-cell-mediated diseases and for the search for new therapeutic strategies in inflammatory diseases.     

Anatomy and behaviour of a post-eruptive rain lahar triggered by a typhoon on Mayon volcano,Philippines

Mayon Volcano in the Philippines, one the world's most active, is situated in a moist, tropical-maritime climate with frequent typhoons. A third of Mayon's eruptions generate destructive lahars (volcanic debris flows and hyperconcentrated streamflows). Lahars also occur during quiescent periods when monsoons and typhoons deliver rains of appropriate intensity and duration to the loose debris on the volcano slopes. Both eruption- and post-eruptive lahars occur most frequently during the typhoon-prone October–December season of the Northeast Monsoon. Post-eruptive lahars, the most poorly documented, are exemplified by a debris-flow event triggered by Saling, a typhoon of only moderate intensity, that occurred in Mabinit Channel on the southeast Mayon flank on October 17–18, 1985, one year after the last Mayon eruption. Detailed pre- and post-Saling surveys docment channel deepening of up to 4 m and maximum lateral erosion of 66 m. The debris flows left prominent, discontinuous multi-level terraces along the length of Mabinit Channel, either from pulsations due to temporary channel blockage, or as levee deposits. A significant volume of debris overtopped channel bends at 250–200 m elevations, coalescing to cover a 200,000 m² area of 4.5° slope with bouldery lateral deposits 1 m thick on the average. Channelized flows below this level plugged 0.5 km of the original channel and replaced it with a new conduit of comparable size. The Saling debris-flow deposits have a remarkably uniform sand-silt mode and less prominent, more variable modes in the pebble-boulder range. Shear strengths of the lateral flows ranged from 0.46×10⁴ to 2.32×10⁴ dn cm^?2; those of the channelized flows at the plug were significantly higher. Reconstructed flow velocity was 3.8 m sec^?1.     

Effect of different acids with Δ9,12-dienoic structures on Δ9 desaturation activity in rat liver microsomes

The effect of oral administration, for 24 or 48 hr, of different octadeca fatty acids containing a 9,12-dienoic structure on the fatty acid composition and Δ9 desaturation activity of liver microsomes of rat fed a fat-free diet was studied. The ethyl esters of linoelaidic and γ-linolenic acids, the methyl ester of linoleic acid and free columbinic acid were administered to rats maintained on a fat-free diet. The supplementation of the fat-free diet with linoelaidate produced no relevant changes in the fatty acid composition pattern of liver microsomes and did not modify the percentage of conversion of palmitic to palmitoleic acid. The addition of linoleate or γ-linolenate to the fat-free diet returned liver microsome Δ9 desaturation activity toward the control and partially restored the liver microsome fatty acid spectrum found in the fat-free diet. Columbinic acid (5-trans-9-cis,12-cis-18∶3), which cannot be transformed into arachidonic acid, also decreased the Δ9 desaturation activity enhanced by the fat-free diet and evoked changes in the microsomal fatty acid composition similar to those produced by the ω6 fatty acids. These results suggest that the modulation of Δ9 desaturase activity evoked by dietary administration of unsaturated acids of ω6 series would depend on thecis double bond configuration of these acids.