Glyconanoparticle-DNA interactions: an atomic force microscopy study.

Glyconanoparticles which present carbohydrate and amino groups motifs at their surface were produced. These particles were highly stable and soluble in aqueous solutions. The presence of the carbohydrate groups also allowed the inclusion of more strongly binding groups, without affecting solubility. The binding of a model DNA, plasmid by these nanoparticles was studied by atomic force microscopy, transmission electron microscopy, and gel electrophoresis. Significant differences between the nanoparticles based on their affinities for the DNA were found, with implications for their potential use as nonviral gene delivery agents.     

Standardizing formats of corporate source data

This paper describe an approach for improving the data quality of corporate sources when databases are used for bibliometric purposes. Research management relies on bibliographic databases and citation index systems as analytical tools, yet the raw resources for bibliometric studies are plagued by a lack of consistency in fied formatting for institution data. The present contribution puts forth a Natural Language Processing (NLP)-oriented method for the identification of the structures guiding corporate data and their mapping into a standardized format. The proposed unification process is based on the definition of address patterns and the ensuing application of Enhanced Finite-State Transducers (E-FST). Our procedure was tested on address formats downloaded from the INSPEC, MEDLINE and CAB Abstracts. The results demonstrate the helpfulness of the method as long as close control of errors is exercised as far as the formats to be unified. The computational efficacy of the model is noteworthy, due to the fact that it is firmly guided by the definition of data in the application domain.     

Metric analysis of the information visibility and diffusion about the European Higher Education Area on Spanish University websites

The purpose of the study proposed in this paper is to evaluate the Spanish public university websites dedicated to the European Higher Education Area (EHEA). To do so, the quality of these resources has been analysed in the light of data provided by a series of indicators grouped in seven criteria, most of which were used to determine what information is made available and in what way. The criteria used in our analysis are: visibility, authority, updatedness, accesibility, correctness and completeness, quality assessment and navigability. All in all, the results allow us to carry out an overall diagnosis of the situation and also provide us with information about the situation at each university, thus revealing their main strengths, namely authority and navegability, and also their chief shortcomings: updatedness, accessibility and quality assessment. In this way it is possible to detect the best practices in each of the aspects evaluated so that they can serve as an example and guide for universities with greater deficiencies and thus help them to improve their EHEA websites.     

The influence of annealing on the conductivity of magnesium films

Polycrystalline magnesium films were deposited under ultrahigh vacuum by thermal evaporation onto a cooled silica substrate. During the growth process of a film a number of lattice defects are incorporated. It was found that the defect density decreases with increasing thickness. An annealing study of the electrical resistance and defect density in magnesium films was made. The results were interpreted on the basis of Vand's theory. The function F₀ expressing the law of distribution of the decay energies exhibited a maximum. For thick films there was no appreciable variation in the activation energy with thickness. In this case the evaluated activation energy E was found to be about 0.35 eV. For very thin films this energy decreases with increasing thickness.     

A new ‘Tailor-made’ methodology for the mechanical behaviour analysis of rubber-like materials: II. Application to the hyperelastic behaviour characterization of a carbon-black filled natural rubber vulcanizate

The purpose of this paper is the modelling of the mechanical behaviour of an elastomeric material, through detailed experimental and numerical procedures, specific to large strains. The experimental technique is based on in-plane kinematics measurements using a speckle extensometer, from which the whole two-dimensional field of in-plane displacements is obtained by a digital image processing [Polymer (2002)]. This part of the work concerns the identification of the constitutive equation for a carbon black natural rubber (NR) vulcanizate. We start by quoting some theoretical considerations relative to rubber elasticity and stress-softening effect, which is the counterpart of the filler reinforcement. Then, we describe the experimental procedure and present data for both non-preconditioned and preconditioned samples. Next, the identification of the constitutive law parameters using a minimization algorithm is driven. Finally, we present the validation of the constitutive model, by its implementation into the finite element code SYSTUS and the numerical simulation of the response of a double edge notched tensile (DENT) specimen.     

Efficient and accurate approach for powder compaction problems

 In this paper, a new approach for powder cold compaction simulations is presented. A density-dependent plastic model within the framework of finite strain multiplicative hyperelastoplasticity is used to describe the highly nonlinear material behaviour; the Coulomb dry friction model is used to capture friction effects at die-powder contact; and an Arbitrary Lagrangian–Eulerian (ALE) formulation is used to avoid the (usual) excessive distortion of Lagrangian meshes caused by large mass fluxes. Several representative examples, involving structured and unstructured meshes are simulated. The results obtained agree with the experimental data and other numerical results reported in the literature. It is shown that, contrary to other Lagrangian and adaptive h-remeshing approaches recently reported for this type of problems, the present approach verifies the mass conservation principle with very low relative errors (less than 1% in all ALE examples and exactly in the pure Lagrangian examples). Moreover, thanks to the use of an ALE formulation and in contrast with other simulations, the presented density distributions do not present spurious oscillations. Received: 20 March 2002 / Accepted: 15 October 2002 The partial financial support of the Ministerio de Ciencia y Tecnología (grant number DPI 2001-2204) is gratefully acknowledged.     

Is it opened or closed? Colombian science on the move

Using recent original data from three different sources, the article exhibits some strengths and weaknesses of science in Colombia. It shows that research in this country is in a process of growth although recent results of this positive trend are still to be confirmed. Comparing the evolution of science in Colombia with that of Latin America as a whole, describing and explaining its geographical and institutional concentration as well as its thematic distribution, it also reveals the interdependance between science production dynamics and international cooperation programmes. A basic argument is that the development of science in this country, even though it is fragile and erratic, does not lack sound bases. The indicators used suggest indeed an autonomous scientific motion and inspiration which does not contradict the internationalization process of Colombian science but rectifies the picture of an excessively isolated or dependent community that used to be portrayed.