Green synthesis of zinc oxide nanoparticles using Amygdalus scoparia Spach stem bark extract and their applications as an alternative antimicrobial,anticancer, and anti-diabetic agent

For the first time in this study, Zinc oxide nanoparticles were biosynthesized by the eco-friendly and cost-effective procedure using Amygdalus scoparia stem bark extract then used as antibacterial, antifungal, anticancer, and anti-diabetic agents. The characterization techniques confirmed the biosynthesis, crystalline nature, structure, size, elemental composition of ZnO NPs and bioactive compounds that exist in A. scoparia extract accounting for Zn²⁺ ion reduction, capping and stabilization of ZnO NPs. The ZnO NPs displayed remarkable inhibitory activity against E. coli, E. aerigenes, S. aureus, P. oryzae, F. thapsinum, and F. semitectum compared to antibiotic standards. The ZnO NPs showed significant inhibitory effects on cancer cell lines, while it had no toxic effect on Vero normal cell line. The ZnO NPs (30 mg/kg)-treated diabetic rats showed significantly higher levels of insulin and lower AST, ALT and blood glucose compared with the STZ induced diabetic group and other treated groups (P < 0.05). The ZnO NPs- and extract-treated rats showed significantly higher levels of IR, GluT2, and GCK expression and lower TNFα expression compared with the STZ induced diabetic rats. Our findings showed that ZnO NPs represented an outstanding performance for biological applications.     

The G3 domain of versican inhibits mesenchymal chondrogenesis via the epidermal growth factor-like motifs

Versican is a highly expressed proteoglycan in zones of developing tissues. To investigate whether versican plays a role in cell differentiation, we studied its role in mesenchymal condensation and chondrogenesis. Here we report that a mini-versican gene product inhibits mesenchymal chondrogenesis but not condensation. The mini-versican-treated mesenchymal cultures form fewer, smaller cartilaginous nodules and produced lower levels of link protein and type II collagen. The versican G3 domain alone, but not G1, was sufficient to inhibit mesenchymal chondrogenesis. Deletion of two epidermal growth factor (EGF)-like motifs in the G3 domain abolished the effect of versican. The G3 domain of aggrecan, which does not contain an EGF-like motif, did not inhibit mesenchymal chondrogenesis. We also generated a chimera construct containing the two EGF-like motifs of versican and the G3 domain of aggrecan, and we observed that this chimera construct inhibited chondrogenesis to a lesser extent than did the full-length versican G3 construct. Direct transfection of mesenchymal cells with different constructs produced similar results. Furthermore, treatment with versican antisense oligonucleotides and transfection with a versican antisense construct promoted chondrogenesis. Taken together, our results strongly suggest that versican inhibits mesenchymal chondrogenesis via its EGF-like motifs.     

Production of calcium nitrate crystals via membrane distillation crystallization using polyvinylidene fluoride/sorbitan trioleate membranes

As an alternative to the energy-intensive evaporation-crystallization method, membrane distillation crystallization (MDC) was applied for the first time to obtain calcium nitrate crystals from its aqueous solution. Calcium nitrate solution was obtained through the reaction between calcium carbonate and nitric acid, and then it was concentrated in the membrane distillation (MD) process and further crystallized. The MD step was conducted using hydrophobic polyvinylidene fluoride (PVDF)/sorbitan trioleate (Span 85) membranes. Span 85 was incorporated into the membrane structure in various concentrations to improve the hydrophobicity of membranes, and the resultant membranes were characterized via different methods. In addition, the resultant calcium nitrate crystals were characterized by X-ray fluorescence (XRF) spectroscopy. The MDC results showed that the optimum amount of Span 85 in the polymeric solution was 4%, which led to the formation of a membrane with higher porosity (67.2%) and water contact angle (95.7°) compared to the neat PVDF membrane. The mentioned membrane exhibited the highest water flux in the MD process compared to the other membranes, and also it produced the highest amount of crystals due to its remarkably better performance in the MD step in terms of feed concentration.     

Glass microparticle- versus microsphere-filled experimental dental adhesives

This study aimed to formulate antibacterial dental adhesives. Phosphate-substituted methacrylate adhesives were modified with 0–20 wt % copper-doped glass microparticles. Two shapes of microparticles were used: regular shaped (microspheres) and irregular shaped (microparticles). The morphology/composition, roughness, monomer conversion (DC%), thermogravimetric analysis, and antibacterial action against S. mutans and P. aeruginosa and ion release were investigated. The results showed that microspheres produced adhesives with a relatively smoother surface than microparticles did. The DC% of adhesives increased with increasing glass filler content. Filled adhesives showed polymer decomposition at ~315 °C and glass melting at 600–1000 °C. The weight loss percent of adhesives decreased with increasing weight percent of fillers. Glass microparticles at 0–20 wt % significantly increased the antibacterial action of adhesives against both bacteria. Glass microspheres at 0–5 wt % significantly increased the antibacterial action of adhesives against both bacteria. Only 20 wt % microparticle-filled adhesive showed an inhibition zone similar to tobramycin (positive control). Microparticle-filled adhesives (with >5 wt % filler) significantly reduced S. mutans more than their microsphere counterparts. Microsphere-filled adhesives (with ≤5 wt % filler) significantly reduced P. aeruginosa more than their microparticle counterparts. Microsphere-filled adhesives showed higher Cu release than their microparticle counterparts. Accordingly, phosphate-substituted methacrylate filled with glass could be used as an antibacterial adhesive. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47832.     

Design of a Compact Monopole Antenna for UWB Applications

In this paper, a low cost, highly efficient and low profile monopole antenna for ultra-wideband (UWB) applications is presented. A new inverted triangular-shape structure possessing meander lines is designed to achieve a wideband response and high efficiency. To design the proposed structure, three steps are utilized to achieve an UWB response. The bandwidth of the proposed antenna is improved with changing meander lines parameters, miniaturization of the ground width and optimization of the feeding line. The measured and simulated frequency band ranges from 3.2 to 12 GHz, while the radiation patterns are measured at 4, 5.3, 6 and 8 GHz frequency bands. The overall volume of the proposed antenna is 26 × 25 × 1.6 mm3 ; whereas the FR4 material is used as a substrate with a relative permittivity and loss tangent of 4.3 and 0.025, correspondingly. The peak gain of 4 dB is achieved with a radiation efficiency of 80 to 98% for the entire wideband. Design modelling of proposed antenna is performed in ANSYS HFSS 13 software. A decent consistency between the simulated and measured results is accomplished which shows that the proposed antenna is a potential candidate for the UWB applications.     

A CPW-fed wearable antenna at ISM band for biomedical and WBAN applications

Wireless Networks - In this paper, a Mercedes-Benz logo antenna with a metal plate located at an optimized distance from the proposed antenna is introduced as a wearable antenna to operate in the...     

A GDQ approach to thermally nonlinear generalized thermoelasticity of disks

Generalized thermoelasticity response of an annular disk subjected to thermal shock on its inner surface is analyzed in this research. The Lord–Shulman theory, which accounts for one relaxation time in the conventional Fourier law, is used to avoid the infinite speed of thermal wave propagation. Unlike the other available works in which the first law of thermodynamics is linearized, the nonlinearity arising from the temperature change is taken into consideration. The first law of thermodynamics in this case becomes nonlinear and the analysis under such formulation is called thermally nonlinear. Two coupled equations, i.e., the radial displacement wave equation and temperature wave propagation equation are obtained. These equations and the associated boundary conditions are discreted through the generalized differential quadrature method. Solution of the time-dependent system of equations is obtained using the Newmark time marching scheme and the successive Picard method. Numerical results are provided for both thermally linear and thermally nonlinear temperature and radial displacement wave propagations. Parametric studies reveal that at higher temperature levels, thermally nonlinear first law of thermodynamics should be considered instead of thermally linear one. Furthermore, the higher the coupling parameter and/or relaxation time, the higher the divergence of thermally nonlinear-/linear-based results.     

Revisiting the free transverse vibration of embedded single-layer graphene sheets acted upon by an in-plane magnetic field

Murmu et al. [23] recently presented a nonlocal model for the transverse vibration of simply supported graphene sheets in the presence of a unidirectional in-plane magnetic field. Further studies showed that the majority of Lorentz’s force components were improperly provided and led to invalid governing equations. To remove such deficiencies, the most general form of Lorentz’s force components is carefully extracted in the present work. The nonlocal equations of motion of the problem are reconstructed and solved again. The influences of crucial parameters on the flexural frequencies of magnetically affected graphene sheets and nanoribbons are examined in detail. Furthermore, the crucial discrepancies between the results obtained in this study and those of the abovementioned previous work are rationally discussed. Some erroneous results of the latter are also rectified.