Characterization of pigmented granules in minocycline-induced cutaneous pigmentation: observations using fluorescence microscopy and high-performance liquid chromatography

Ambiguous abdominal situs, asplenia/polysplenia and severe cardiac malformations characterize heterotaxy in humans. These anomalies result from the inability of the developing embryo to establish normal left-right asymmetry. We have studied an interesting family in which the heterotaxy phenotype segregates as an X-linked recessive trait. In order to map the heterotaxy locus (HTX), we have analysed 39 family members using highly-polymorphic microsatellite markers from the X chromosome. One of these markers, DXS994, shows no recombination with the disease locus in 20 informative meioses. Linkage analysis results in a maximum lod score of 6.37. Current genetic and physical mapping data assign the order of loci in Xq24-q27.1 as cen-DXS1001-(DXS994, HTX)-DXS984-tel. These results establish the first mapping assignment of situs abnormalities in humans.     

An experimental and numerical investigation of ductile crack growth characteristics in surface cracked specimens under combined loading

Fracture mechanics tests have been performed in the upper shelf region of a steel on large surface cracked plate (SCT) specimens and on small compact tension (CT) specimens. Some of the SCT specimens were subjected to combined tension and bending in such a way that the loading was strongly non-proportional. Crack growth characteristics were compared between the specimens in order to assess possible influences of geometry and nonproportional loading. The differences observed could unambiguously be reduced to and correlated with differences in constraint. Constraint parameters were evaluated by detailed three-dimensional finite element computations and quantities for growing cracks were interpreted on the basis of deformation theory considerations, in analogy with the commonly used J _R-philosophy. It was noted that the initiation of ductile crack growth along a three-dimensional crack front appears to be independent of the degree of local constraint. However, the increase in toughness for a growing crack was markedly affected by the degree of local constraint. Some estimates of the constraints effects regarding stability considerations were also made.     

Sociopolitical effects on personality research.

Comments on L. R. Goldberg's (see record 1993-17546-001) history of the Big Five framework of personality traits and elaborated on its use. The reasons why industrial/organizational psychologists de-emphaszied the impact of personality on the job peformance in the late 1960s and 1970s and re-emphasized it in the 1980s are addressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tribological properties of oil-soluble polyolefins

Translated from Khimiya i Tekhnologiya Topliv i Masel, No. 11, pp. 17–18, 23, November, 1993.     

A multivariate mixed linear model for meta-analysis.

A multivariate mixed-effects approach for meta-analysis is presented. The approach (a) incorporates as outcomes multiple effect sizes per study; (b) allows different studies to have different subsets of effect sizes; and (c) treats each study's effect sizes as random realizations from a population of possible effect sizes. Application is illustrated via reanalysis of data from studies assessing the effects of coaching on verbal and mathematical subtests of the Scholastic Aptitude Test. Covariance components are estimated via restricted maximum likelihood (REML); inferences about regression coefficients and specific study effect sizes are based on their joint conditional distribution given the REML covariance component estimates. The approach can be implemented via now-standard software for unbalanced hierarchical data. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On the Possibility of Observing Third Sound on 3He

This paper focuses on the hydrodynamics of third sound on a superfluid ³ He film. We solve the hydrodynamical equations in the limit of thick films with weak interaction with the substrate. The surface tension at the free interface is shown to have a large effect on the third sound velocity and on the attenuation for frequencies larger than 1Hz. In the case of a diffusely scattering substrate a ripplon-like dispersion relation is found for this frequency range.     

Alteration of Sertoli cell differentiation in the presence of carcinoma in situ in human testes

PURPOSE: We investigated Sertoli cells in testicular biopsies with carcinoma in situ (CIS) in respect to cytokeratin expression to elucidate the status of Sertoli cell differentiation adjacent to CIS in human testes. Cytokeratin 18 intermediate filaments indicate a state of undifferentiation usually observed in Sertoli cells of prepubertal testes. MATERIALS AND METHODS: 29 testicular biopsies presenting CIS were investigated by means of immunohistochemistry, using a polyclonal antibody against placental-alkaline phosphatase to detect CIS cells and a monoclonal antibody against human cytokeratin 18 to show expression of cytokeratin 18 intermediate filaments in Sertoli cells. RESULTS: All tubules bearing CIS showed positive cytokeratin expression of Sertoli cells if tubules were devoid of normal germ cells. However, a total of 13 specimen revealed CIS cells together with normal germ cells. In the presence of CIS cells together with round or elongated spermatids, adjacent Sertoli cells did not express cytokeratin immunoreactivity. In the case of combined presence of CIS and spermatogonia and primary spermatocytes, Sertoli cells could be found either immunopositive or immunonegative, and were positive in tubules with CIS and spermatogonia only. CONCLUSIONS: Sertoli cells associated with CIS cells undergo a process of dedifferentiation, seen by the re-expression of cytokeratin intermediate filaments. We suggest that this dedifferentiation results in a loss of Sertoli cell function and leads to a cessation of spermatogenic activity.     

The role of perspective in the accessibility of goals during reading.

An implicit assumption of several causal reasoning models is that readers adopt the goals of a narrative's protagonist during text comprehension. In apparent violation of this assumption, readers participating in Experiment 1 of the present study drew inferences relevant to a protagonist's goal even when that goal was already satisfied from the perspective of the protagonist. In Experiments 2 and 3, participants were explicitly asked to view the text situation from the point of view of the protagonist. In this case, the goals of the reader and the protagonist should be the same. In these experiments, participants focused on the goals of the protagonist only when those goals had not been satisfied from the perspective of the protagonist. These results are discussed in terms of reader- and character-based perspectives and in terms of text characteristics that cue perspective taking. (PsycINFO Database Record (c) 2010 APA, all rights reserved)