Positive and negative symptoms in chronic psychiatric outpatients: Reliability, stability, and factor structure.

This study evaluates 2 instruments measuring positive and negative symptoms, the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms, for their reliability, internal consistency, and temporal stability. The interrelationships and course of specific symptoms are examined to ask whether they represent 1, 2, or more separate pathological processes. Symptoms were assessed in 399 outpatients followed for the long-term effects of antipsychotic medications; a subset (n?=?229) was given the instruments twice, approximately 24 months apart. Results suggest four distinct types of symptoms in severe mental disorders. Two correspond to general definitions of positive and negative symptoms. Attentional Impairment, Formal Thought Disorder, and possibly Bizarreness and Avolition-Apathy emerge as separate categories of symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Injury control in practice. Home radiator burns in inner-city children

OBJECTIVE: To describe thermal burns from radiators in the homes of children in the inner city and an intervention to decrease the risk for this pediatric injury. SETTING: Academic medical center in Chicago. PATIENTS: Case series of 10 radiator-related burns. RESULTS: The burns described were found to be clustered in an area of a public housing project served by steam radiators. No burns were associated with hot water radiators. Just 14% of housing units with young children had adequate radiator covers and radiator pipe insulation. Radiator covers and insulation have now been replaced or repaired in all units of the 11 housing project buildings served by steam radiators. CONCLUSIONS: Steam radiators in the home represent a particular childhood burn hazard. Community-based clinicians are in a unique position to recognize local patterns of injury and work with other agencies in injury control efforts.     

Melatonin administration does not affect isoproterenol-induced LVH.

Left ventricular hypertrophy (LVH), a common sequella of hypertension, is associated with increased incidence of sudden cardiac death. The study reported herein measured the effect of melatonin on the heart in the setting of direct cardiac myocyte stimulation with isoproterenol, thus minimizing the role of autonomic output from the suprachiasmatic nucleus (SCN) and clarifying the effect of melatonin on LVH, an outcome of chromic hypertensions. Results show that daily injections of high dosages of melatonin do not affect heart weight:body weight or heart weight:tibia length ratios in the setting of isoproterenol-induced hypertrophy, suggesting that the cardiovascular effects of melatonin observed by others are not due primarily to a direct effect of melatonin on cardiac myocytes but to another mechanism, possibly melatonin modulation of SCN output. Melatonin has no effect on isoproterenol-induced LVH, suggesting that its cardiovascular effects are not due to a direct effect on cardiac myocytes. Melatonin has been found to have a significant effect on hypertension; however, in this study, one effect of extended hypertension, cardiac hypertrophy, which can ultimately lead to cardiac failure, was not affected, even by very large doses of melatonin in a chemically induced hypertrophy mouse model. It has been suggested that the effect of melatonin on hypertension is comparable to common antihypertensive agents.     

Potential application of p53 as an intermediate biomarker in Barrett's esophagus

Diagnosis of the neoplastic progression in Barrett's esophagus using the histologic classification of dysplasia is frequently difficult. The tumor suppressor protein p53, when mutated, confers a promoter effect on cell growth. The purpose of this study was to evaluate the applicability of p53 as an intermediate biomarker of malignancy in Barrett's esophagus. Archival analysis of 100 biopsy specimens of Barrett's esophagus and 10 esophageal adenocarcinomas were compared with 35 chronic esophagitis biopsy specimens. Immunocytochemistry using an anti-p53 monoclonal antibody was performed and elevated immunoreactivity quantitated microscopically. Data were analyzed using a logistic regression model. Significant p53 immunoreactivity occurred as follows: chronic esophagitis (0%), Barrett's esophagus without dysplasia (10%), with low-grade dysplasia (60%), with high-grade dysplasia (100%), and adenocarcinoma (70%). All cases of Barrett's esophagus were significantly immunoreactive when compared with the chronic esophagitis cases (p = 0.001). There was an increase in p53 immunoreactivity as the histologic classification progressed toward adenocarcinoma (p = 0.001). Progression to high-grade dysplasia may be predicted based on p53 immunoreactivity. These findings suggest a role for p53 as an intermediate biomarker in Barrett's esophagus.     

Morphological Development in Children's Writing.

This study focused on the development of children's control of morphological markers in their writing. The authors examined inflectional and derivational morphological forms within narratives written by 247 3rd and 4th graders. The majority of 3rd and 4th graders used inflectional forms consistently and accurately in their writing. In contrast, fewer students used derived forms, and significantly more 4th than 3rd graders used them accurately. Results indicate that children's control of morphological structures in their writing mirrors that in their speech: Inflectional morphology is largely mastered by age 9 or 10, but skills with derivational morphology continue to develop in middle childhood. The relationships among written morphological accuracy, reading, and spelling were also examined. Written morphological accuracy predicted reading and spelling performance at both grade levels. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Absorption of isomeric, palmitic acid-containing triacylglycerols resembling human milk fat in the adult rat

The effect of the positional distribution of palmitic acid (16:0) in triacylglycerols (TAG) on 16:0 apparent absorption in adult rats was investigated. The rats were fed two diets which contained 30 energy % as fat with identical total fatty acid compositions, both containing 30% 16:0. The Betapol diet contained TAG with 73% of total 16:0 in the sn-2 position, the control diet contained TAG with 6% of total 16:0 in the sn-2 position. After six weeks on these diets, the rats were killed two or six hours after the last meal, and the small intestine was removed, cut into 10-cm segments, and the fatty acid composition of the segment's contents was determined. At both time points the amount of 16:0 in the intestinal segments starting at 40 cm from the stomach was much lower in the animals fed Betapol than in the animals fed the control diet. Overall absorption of 16:0 and stearic acid was significantly greater in the Betapol group. Absorption of oleic and linoleic acid from the small intestine was similar in both groups, although the overall absorption was significantly greater in the animals fed Betapol. Total fat absorption was significantly higher in the Betapol-fed rats than in the control-fed rats. No effect on calcium and nitrogen absorption, on plasma total cholesterol and TAG levels, and on bodyweights (growth) was seen. The data demonstrate that the positional distribution of the fatty acids in the TAG molecule affects the site of absorption in the small intestine and particularly the net absorption of saturated fatty acids.     

A multimode 0.3-200-kb/s transceiver for the 433/868/915-MHz bands in 0.25-/spl mu/m CMOS

A fully integrated transceiver suitable for low-data-rate wireless telemetry and sensor networks operating in the license-free ISM frequency bands at 433, 868, or 915 MHz implemented in 0.25-/spl mu/m CMOS is presented. G/FSK, ASK, and OOK modulation formats are supported at data rates from 0.3 to 200 kb/s. The transceiver's analog building blocks include a low-noise amplifier, mixer, channel filter, received signal-strength indication, frequency synthesizer, voltage-controlled oscillator, and power amplifier. FSK demodulation is implemented using a novel digital complex-frequency correlator that operates over a wide modulation-index range and approximates matched filter detection performance. Automatic gain control, automatic frequency control, and symbol timing recovery loops are included on chip. Operating in the 915-MHz band in FSK mode at 9.6 kb/s, the receiver consumes 19.7 mA from a 3-V supply and achieves a sensitivity of -112.8dBm at 0.1% BER. The transmitter consumes 28.5 mA for an output power of 10 dBm and delivers up to 14 dBm.     

Experimental 0.1 μm p-channel MOSFET withp+-polysilicon gate on 35 Å gate oxide

Very-high-transconductance 0.1 μm surface-channel pMOSFET devices are fabricated with p⁺-poly gate on 35 Å-thick gate oxide. A 600 Å-deep p⁺ source-drain extension is used with self-aligned TiSi₂ to achieve low series resistance. The saturation transconductances, 400 mS/mm at 300 K and 500 mS/mm at 77 K, are the highest reported to date for pMOSFET devices     

Pulmonary vascular permeability after cardiopulmonary bypass and its relationship to oxidative stress

A straightforward quantitative method for gas chromatography-mass spectrometry determination of isosorbide 5-mononitrate (IS5MN) and its related impurities such as isosorbide (IS), isosorbide diacetate (ISDA) and isosorbide 2-acetate-5-nitrate (IS2A5N) in raw materials as well as in dosage formulations is developed. The recovery of these materials was found to be 100.4 +/- 2.4, 99.3 +/- 4.7, 97.8 +/- 5.2 and 100.1 +/- 3.1%, while the detection limits were 27.2, 1.26, 1.02 and 0.78 micrograms in dosage formulations for IS5MN, ISDA, IS2A5N, and IS, respectively. The applicability of the method was tested by analysing three different formulations of IS5MN.