Frequency effects in spoken and visual word recognition: Evidence from dual-task methodologies.

The authors report 3 dual-task experiments concerning the locus of frequency effects in word recognition. In all experiments, Task 1 entailed a simple perceptual choice and Task 2 involved lexical decision. In Experiment 1, an underadditive effect of word frequency arose for spoken words. Experiment 2 also showed underadditivity for visual lexical decision. It was concluded that word frequency exerts an influence prior to any dual-task bottleneck. A related finding in similar dual-task experiments is Task 2 response postponement at short stimulus onset asynchronies. This was explored in Experiment 3, and it was shown that response postponement was equivalent for both spoken and visual word recognition. These results imply that frequency-sensitive processes operate early and automatically. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Carminic acid-promoted oxygen radical damage to lipid and carbohydrate

The food colouring carminic acid redox cycles to produce free radicals. These radicals, in the presence of trace amounts of iron salts, readily damage membrane lipid and degrade the carbohydrate deoxyribose. Damage to membrane lipid appears to involve mainly organic oxygen radicals such as alkoxy and peroxy radicals, whereas that to deoxyribose implicates the hydroxyl radical formed in a Fenton-type reaction. Antioxidants and iron chelators prevent such damage.     

Reducing the effect of complexity on volume model evaluation

A major problem with volume modelling systems is that processing times may increase with model complexity in a worse than linear fashion. The authors have addressed this problem, for picture generation, by repeatedly dividing the space occupied by a model, and evaluating the sub-models created only when they meet a criterion of simplicity. Hidden surface elimination has been integrated with evaluation, in such a way that major portions of the model which are not visible are never evaluated. An example demonstrates a better than linear relationship between model complexity and computation time, and also shows the effect of picture complexity on the performance of the process.     

Internal consistency in plausible reasoning systems

The usual approach to plausible reasoning is to associate a validity measure with each fact or rule, and to compute from these a validity measure for any deduction that is made. This approach is shown to be inappropriate for some classes of problems, particularly those in which the evidence is not internally consistent. Three current plausible reasoning architectures are summarised and each applied to the same small task. An analysis of the performance of these systems reveals deficiencies in each case. The paper then outlines a new approach based on the discovery of consistent subsets of the given evidence. This system can be used either in isolation or in conjunction with a validity-propagating architecture. Comparative results from implementations of all four systems are presented.     

Practicing A and B psychotherapists' responses to schizoid and neurotic patient prototypes.

83 practicing male psychotherapists completed the A-B Scale of H. Schiffman et al (1967), responded to recordings of schizoid and neurotic patient prototypes, and rated their subjective reactions to each type. Multivariate analysis revealed a significant overall A-B Type by Patient Type interaction. Although liking and ease of responding were higher in therapist–patient dyads, which the literature suggests are effective (A—schizoid, B—neurotic), felt compatibility and desire to work with the patient were higher in the opposite ("mismatched") dyads. Results suggest that subjective reactions underlying the A-B interaction effect are complex and that therapists respond in a differentiated, not global, fashion. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of lead on globin synthesis in vitro

A defect in heme synthesis is well documented to occur in lead intoxication. Globin synthesis and the alpha/beta globin chain synthesis ratio have been shown to be disturbed in lead poisoning. To elucidate further the nature of the inhibitory effect of lead on hemoglobin synthesis, reticulocyte-rich peripheral blood samples have been incubated with lead at concentrations of 10(-6), 10(-5), and 10(-4) M, equivalent to 20, 200, and 2,000 mug/dl (.96, 9.6 and 96.0 mumol/l), respectively. The incorporation of tritiated leucine into globin was determined. Globin chain synthesis decreased to 85, 49 and 15% of the control value with increasing lead concentrations. The effect of heme on inhibition of globin synthesis by lead was studied by incubating reticulocyte-enriched blood with lead 10(-5) M (200 mug/dl; 9.6 mumol/l) in the presence or absence of heme at a concentration of 10(-3) M. Lead alone depressed the incorporation of tritiated leucine to 45% of control, while globin synthesis with heme alone was 109% of control. Although in the presence of both heme and lead, the mean incorporation of leucine into globin was 69.2% of control, the increase was not significantly different from that obtained with lead alone. It is concluded that (1) lead has an inhibitory effect on globin synthesis at a concentration considered to be within the acceptable range encountered in environmental lead pollution, and the extent of inhibition is dose-dependent; (2) the effect of lead on globin synthesis is not significantly prevented by heme and, therefore, does not appear to be mediated through the well-documented inhibitory effect of lead on heme synthesis.     

The generalized earthquake-location (GENLOC) package: an earthquake-location library

We describe a library and associated set of applications for locating seismic events. The library is called the GENeralized LOCation (GENLOC) library because it is a general library that implements most methods commonly used for single event locations. The library has a flexible implementation of the standard Gauss–Newton method with many options for weighting schemes, inversion methods, and algorithms for choosing an initial location estimate. GENLOC also has a grid-search algorithm that makes no assumptions about the geometry of the grid it is searching returning only the point with a best fit solution for the specified residual norm. GENLOC supports both arrival time and array slowness vector measurements. A unique feature is the strong separation between the travel time/earth model problem and the location estimations. GENLOC can utilize data from any seismic phase for which the user can supply an earth model and method to compute theoretical travel times and/or slowness values. The GENLOC library has been used in five different working applications: (1) a simple command line program, (2) an interactive graphical user interface version used in an analyst information system, (3) a database-driven relocation program, (4) a recent implementation of the progressive multiple event location method, and (5) a real-time location program. We ran a validation test against LOCSAT and found reasonable consistency in estimated locations. We attribute observed differences in the solutions to roundoff errors in different calculators used by the two programs.     

Incompressible moving boundary flows with the finite volume particle method

Mesh-free methods offer the potential for greatly simplified modeling of flow with moving walls and phase interfaces. The finite volume particle method (FVPM) is a mesh-free technique based on interparticle fluxes which are exactly analogous to intercell fluxes in the mesh-based finite volume method. Consequently, the method inherits many of the desirable properties of the classical finite volume method, including implicit conservation and a natural introduction of boundary conditions via appropriate flux terms. In this paper, we describe the extension of FVPM to incompressible viscous flow with moving boundaries. An arbitrary Lagrangian–Eulerian approach is used, in conjunction with the mesh-free discretisation, to facilitate a straightforward treatment of moving bodies. Non-uniform particle distribution is used to concentrate computational effort in regions of high gradients. The underlying method for viscous incompressible flow is validated for a lid-driven cavity problem at Reynolds numbers of 100 and 1000. To validate the simulation of moving boundaries, flow around a translating cylinder at Reynolds numbers of 20, 40 and 100 is modeled. Results for pressure distribution, surface forces and vortex shedding frequency are in good agreement with reference data from the literature and with FVPM results for an equivalent flow around a stationary cylinder. These results establish the capability of FVPM to simulate large wall motions accurately in an entirely mesh-free framework.     

The function and activity of certain membrane enzymes when localized on- and off- the membrane

A group of enzymes known to be involved in group translocation-type transport mechanisms for the uptake of a variety of nucleotide precursors are enzymatically active both in their natural membrane milieu and in aqueous solution. The activity in aqueous solution markedly differ, however, from the enzymatic activity when the enzyme is membrane localized. The adenine phosphoribosyltransferase (PRT) of E. coli (Hochstadt-Ozer and Stadtman, 71a) is capable of carrying out an exchange reaction between the base moieties of adenine and AMP without requiring P-ribose-PP as an intermediate; the enzyme in aqueous solution requires P-ribose-PP, indicating a different reaction mechanism in the two environments. Like the adenine PRT of E. coli, the hypoxanthine PRT of Salmonella typhimurium (Jackman and Hochstadt, '76) also carried out an exchange reaction on the membrane only and also is more sensitive to a number of inhibitors in aqueous solution relative to the sensitivity when embedded in the membrane. In addition, however, the hypoxanthine PRT, while restricted to hypoxanthine as a substrate in the membrane, also accepts guanine as substrate in its soluble form. The membrane capacities reas determined in a guanine PRT deletion strain (Jackman and Hochstadt, '76). Finally, in mammalian cell lines purine nucleoside phosphorylase, which translocates the ribose moiety of inosine across the plasma membrane of mouse fibroblasts undergoes a 30-fold increase in substrate turnover number upon liberation from the membrane. These data raise two important caveats with respect to study of membrane enzymes and transport. Firstly, an enzyme once solubilized and found to differ kinetically from substrate transport in situ cannot be excluded from participating in translocations in the membrane on the basis of its activity in aqueous solution. Secondly, an enzyme which "appears" largely soluble upon cell rupture cannot be assumed to be a cycloplasmic enzyme because of majority of the solubilized activity may represent only a small fraction of the enzyme molecules highly activated concomitant to their solubilization. In this latter case the ability to activate enzyme still residing on the membrane (e.g., with detergents) would be necessary in order to estimate total membrane associated activity after cell rupture.