Prediction of NSCLC recurrence from microarray data with GEP

Lung cancer is one of the deadliest diseases in the world. Non‐small cell lung cancer (NSCLC) is the most common and dangerous type of lung cancer. Despite the fact that NSCLC is preventable and curable for some cases if diagnosed at early stages, the vast majority of patients are diagnosed very late. Furthermore, NSCLC usually recurs sometime after treatment. Therefore, it is of paramount importance to predict NSCLC recurrence, so that specific and suitable treatments can be sought. Nonetheless, conventional methods of predicting cancer recurrence rely solely on histopathology data and predictions are not reliable in many cases. The microarray gene expression (GE) technology provides a promising and reliable way to predict NSCLC recurrence by analysing the GE of sample cells. This study proposes a new model from GE programming to use microarray datasets for NSCLC recurrence prediction. To this end, the authors also propose a hybrid method to rank and select relevant prognostic genes that are related to NSCLC recurrence prediction. The proposed model was evaluated on real NSCLC microarray datasets and compared with other representational models. The results demonstrated the effectiveness of the proposed model.Inspec keywords: lung, cancer, lab‐on‐a‐chip, genetics, patient diagnosisOther keywords: NSCLC recurrence prediction, microarray data, GE programming, nonsmall cell lung cancer, cancer recurrence, histopathology data, microarray gene expression, prognostic genes     

The interlaminar shear failure characteristics of asphalt pavement coupled heating cables

Nowadays, heating cables are used as heat sources for heating pavements in practical engineering. However, there is a contradiction between the snow melting function and the interlaminar stability of heating pavement. In order to solve the contradiction, the interlaminar failure behavior of asphalt mixture coupled heating cables specimen (AMCS) was researched, through experiments and the finite element method. Under the different conditions of heating cables and rolling times, a series of direct shear tests was performed at the interface of AMCS, to compare the interlaminar stability of three different AMCS. Meanwhile, based on the bilinear cohesive zone model and coulomb friction model a 2D finite element model was established, to simulate this shear failure processes and make up for the limitations of the experiment. According to above test and simulation results, the failure mechanism and the weakest interface in AMCS were found, and the influence of the heating cable’s diameter and embedded spacing on the interlaminar shear strength were found. Then, a modified coulomb theorem model was proposed to predict the shear strength of the AMCS. This research enriches the design theory of the heating pavement and it has great significance for its structural design of heating asphalt pavement.     

Aggregation-induced emission luminogen-assisted stimulated emission depletion nanoscopy for super-resolution mitochondrial visualization in live cells

Nano Research - Aggregation-induced emission luminogens (AIEgens) are fluorescent agents that are ideal for bioimaging and have been widely used for organelle targeting, cellular mapping, and...     

A review on mechanisms and recent developments of nanomaterials based carbon fiber reinforced composites for enhanced interface performance

Carbon fiber reinforced composites have attracted lots of attention in many fields. However, on account of the poor infiltration of resin to carbon fiber, the weak interface performance between fiber and resin has been restricting the interface properties of composites. In recent progress, the review attaches more importance to the introduction of the third phase monomer, which mainly uses physical and chemical methods to assemble nanomaterials (such as carbon nanotubes, graphene, etc.) on the carbon fiber surface to modify the interface structure of the carbon fiber reinforced composites, and all of them have been demonstrated in this paper. Furthermore, the effects of introducing nanomaterials on the structure of the fiber/resin interface and the relationship between multi-scale interface structure and properties have been investigated. It can be seen that the design idea of researchers mainly uses one or more theories to improve the interface properties of carbon fiber reinforced composites, such as transition layer, chemical bonding, mechanical interlocking, infiltration, diffusion, and adsorption. In brief, this work provides some novel insights for the preparation of carbon fiber reinforced composites with excellent interlaminar shear strength.     

影响结晶化玻璃板材质量因素的分析

研究了烧结法生产结晶化玻璃装饰板材中的气孔、翘板及炸裂产生的原因以及解决的方法。     

One-step two-wavelength holography

One-step two-wavelength holography is obtained with twointerferometric beams with different wavelengths by means of apolarizing modulation produced by a liquid-crystal lightvalve. This holographic method eliminates the need for preliminarystatic recording of the hologram and permits one-step two-wavelengthholographic testing to produce results easily in real time.     

基于SIMD结构的多标准LDPC译码器的VLSI实现

近年来,支持多标准的LDPC译码器已逐渐成为研究的热点.与传统译码器相比,所设计的LDPC译码器具有以下优点:1.实现了一个码率、码长可配置结构,进而可以支持多种标准;2.采用了一种改进型TPMP算法,使译码器的存储器容量大大减少,避免了因分块LDPC码的非规则性所造成的数据冲突问题;3.采用基于SIMD处理器的硬件结构,实现了硬件的高度规整性,易于芯片布局布线;4.设计了一个6级可配置流水线,可分时构造校验节点处理单元和变量节点处理单元,提高了硬件利用率和系统数据吞吐率.用这种架构实现了一个同时支持CMMB和DTMB两个标准的多标准LDPC译码器;芯片规模为75万门,时钟频率为220MHz,数据吞吐率为300Mbps.     

3种本质安全评价方法在EDC过程中的应用研究

简要叙述ISI、i-safe和IBI 3种典型的本质安全评价方法,说明其含有的参数及指数的计算方法;然后使用这3种方法评价了直接氯化法、氧氯化法、改进的氧氯化法3个EDC生产流程.评价结果表明:不同方法评价相同的几个过程,得到的各过程安全性的高低是一致的:直接氯化法最高、氧氯化法次之、改进的氧氯化法安全性最差:评价同一个流程时,ISI法评价得到的数值最大,i-Safe法次之,IBI法最小.结合评价的过程从参数的个数及覆盖面的大小、参数取值的主观性程度、获取所需信息的难易程度和结果的灵敏性4方面比较和分析3种评价方法,最后总结得到3种方法中IBI法的优势最大.     

Stabilization of all-pole unstable delay processes by simple controllers

The stabilization of a class of all-pole unstable delay processes of arbitrary order with single unstable pole by means of simple controllers is investigated in details. Complete stabilizability conditions are established and the computational methods for determining stabilizing controller parameters presented. They provide theoretical understanding of such a stabilization problem and can also serve as practical guidelines for actual controller design.     

基于进程执行轮廓的缓冲区溢出攻击效果检测

缓冲区溢出攻击效果检测对缓冲区溢出安全防御工作具有重要意义,该文分析进程与Windows NativeAPI的关系,以Windows NativeAPI为数据源进行攻击效果检测。提出执行轮廓的概念及其建立方法,在分析缓冲区溢出攻击效果的基础上,提出基于进程执行轮廓的缓冲区溢出攻击效果检测方法,实验结果表明该方法的有效性。