THE EFFECT OF MALEIC HYDRAZIDE TREATMENT ON NITROGENOUS CONSTITUENTS OF POTATO TUBERS AND ON MINERAL CHANGES IN TUBERS AND SPROUTS

The effect of maleic hydrazide treatment on the contents of total and non-protein nitrogen, protein and minerals was assessed on cortex and pith tissues of two potato varieties (Katahdin and Kennebec) grown at two locations (Long Island and Ithaca, NY). Maleic hydrazide significantly increased (p < 0.01) the total and non-protein nitrogen of cortex tissue but showed no significant effect on protein and mineral contents. Sprouts and bud tissue from Katahdin and Kennebec tubers grown at Ithaca were assessed for mineral composition. In both varieties the amounts of calcium, magnesium, manganese and zinc in sprouts were significantly increased (p < 0.01) by maleic hydrazide treatment. No significant effect of MH on mineral content of bud tissue was observed.     

Synthesis and characterization of carboxymethyl chitosan hydrogel: Application as site specific delivery for lercanidipine hydrochloride

In the present study, carboxymethylchitosan (CMCS) was prepared from chitosan, crosslinked with glutaraldehyde and evaluated in vitro as a potential carrier for site specific drug delivery of lercanidipine hydrochloride (LERH). LERH was incorporated at the time of crosslinking of CMCS. The chitosan was evaluated for its degree of deacetylation (DD) and average molecular weight, which were found to be 84·6% and 3·5 × 10⁴ Da, respectively. The degree of substitution on prepared CMCS was found to be 0·68. All hydrogel formulations showed more than 86% and 77% yield and drug loading, respectively. The swelling behaviour of prepared hydrogels were checked in different pH values, 1·2, 6·8 and 7·4, indicated pH responsive swelling characteristic with very less swelling at pH 1·2 and quick swelling at pH 6·8 followed by linear swelling at pH 7·4 with slight increase. In vitro release profile was carried out at the same conditions as in swelling and drug release was found to be dependent on swelling of hydrogels and showed biphasic release pattern with non-fickian diffusion kinetics at higher pH. The carboxymethylation of chitosan, entrapment of drug and its interaction in prepared hydrogels were checked by FTIR, ¹H-NMR, DSC and p-XRD studies, which confirmed formation of CMCS from chitosan and absence of any significant chemical change in LERH after being entrapped in crosslinked hydrogel formulations. The surface morphology of formulation S6 was checked before and after dissolution, revealed open channel like pores formation after dissolution.     

Calculated Thermodynamic Data and Metastable Immiscibility in the System SiO2-Al2O3

Thermodynamic data on activities, activity coefficients, and free energies of mixing in SiO₂-Al₂O₃ solutions were calculated from the phase diagram. Positive deviations from ideal mixing in the thermodynamic data suggest a tendency for liquid immiscibility in both SiO₂- and Al₂O₃-rich compositions. The calculated data were used to estimate regions of liquid-liquid immiscibility. A calculated metastable liquid miscibility gap with a consolute temperature of ∼1540^°C at a critical composition of ∼36 mol% Al₂O₃ was considered to be thermodynamically most probable; the gap extended from ∼11 to °49 mol% Al₂O₃ at 1100^°C. SiO₂-rich glass compositions showed evidence of glass-in-glass phase separation when examined by direct transmission electron microscopy.     

Melt Processing and Properties of Barium-Sialon Glasses

Bulk oxynitride glasses in the system Ba-Sialon were prepared by cooling homogenized melts from ∼1740°C at ∼50°C/min. The microchemistry, microstructure, and properties of these materials were studied by DTA, dilatometry, electron microscopy, and energy dispersive X-ray analysis. Up to ∼ 7 at.% nitrogen was retained in the glasses by the conventional glass-processing techniques used. Microscopically homogeneous glasses were obtained despite macroscopic segregation of millimeter-sized metallic spheres consisting of Si and Fe. Incorporation of nitrogen in the glass network led to decreasing thermal expansion coefficients, higher glass-transition temperatures, and greater values of indentation hardness with increasing nitrogen content.     

An improved branching scheme for the branch and bound procedure of scheduling n jobs on m parallel machines to minimize total weighted flowtime

A branch and bound procedure to solve the n job, m parallel machine problem for the weighted flowtime criterion has been developed by Elmaghraby and Park (1974) and further modified by Barnes and Brennan (1977). This paper proposes a branching scheme different from theirs and shows its superiority. Also, some new and simple results are presented which are easy to implement to obtain an efficient branch-and-bound algorithm. In addition, a new and improved lower bound is developed which is easy to compute.     

Indian medicinal plants are effective in the treatment and management of COVID-19

Indian medicinal plants are referred to as the “nectar of life” owing to their phytochemicals and bioactive complexes that are beneficial in treating diseases. Coronavirus disease 2019 (COVID-19) is a global health issue without any proper medication. The indigenous plants of India can be exploited to control the precise signs of SARS-CoV-2. The Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy) has advised routine usage of medicinal plants for COVID-19. Medicinal plants like Zingiber officinalis, Azadirachta indica, Ocimum sanctum, Nigella sativa, Withania somnifera, Curcuma longa, Piper nigrum, Allium sativum, Tinospora cordifolia, etc. have immunity-boosting, antiviral, antibacterial, antioxidant and anti-inflammatory actions that can suppress and treat symptoms of COVID-19. In vitro, in vivo as well as in silico validation, these phytochemicals can help us to manage and treat COVID-19 disease. This integration of traditional knowledge in the prophylaxis of corona infection and current skills validating it for the development of precise and powerful therapeutic approaches will more efficiently resolve different clinical aspects of COVID-19. The review focuses on both traditional and emergent methods to prevent and treat COVID-19 with various Indian medicinal plants along with their phytochemicals.