Investigation on replication of microfluidic channels by hot embossing

In this study, effects of embossing temperature, time, and force on production of a microfluidic device were investigated. Polymethyl methacrylate (PMMA) substrates were hot embossed by using a micromilled aluminum mold. The process parameters were altered to observe the variation of replication rate in width and depth as well as symmetry of the replicated microfluidic channels. Analysis of variance (ANOVA) on the experimental results indicated that embossing temperature was the most important process parameter, whereas embossing time and force have less impact. One distinguishing aspect of this study is that, the channels were observed to be skewed to either side of the channel depending on the location of the protrusions on the mold. The mechanism of the skewness was investigated by finite element analysis and discussed in detail. Results showed that the skewness depends on the flow characteristics of the material and could be reduced by increasing the embossing temperature. The best replication rates were obtained at parameter settings of 115°C, 10?kN, and 8?min for the molds with minimum 56?µm wide features of 120?µm depth. We also showed that the fabricated channels could be successfully sealed by solvent-assisted thermo-compressive bonding at 85°C under 5.5?kN force.     

Electrical and Dielectric Properties of Y<Superscript>3+</Superscript>-Substituted Barium Hexaferrites

In this study, Y³⁺ ion-substituted M-type barium hexaferrites (BaM; BaFe₁₂O₁₉) were fabricated via facile ceramic route. As-prepared powders were characterized by X-ray powder diffractometry (XRD), Fourier transform infrared (FT-IR) spectroscopy, and impedance spectroscopy. XRD (Rietveld) analyses confirmed the presence of a single characterization of all samples (except x = 0.0 and 0.1 samples). The crystallite sizes of products are found in the range of 47.2–63.2 nm. Spectral analysis (FT-IR) also presented the formation of spinel structure for all products. The ac conductivity of the substituted samples was found to initially decrease slightly with increase in Y³⁺ compared with unsubstituted, and then variation tendency changes at the medium substitution ranges are observed with a different attitude against temperature. In the end, the lower conductivity for high substitutions is recorded and increases as functions of frequency while it also increases with the elevation of temperature. It was observed that ac conductivities of products increased by increasing frequency which indicate that observed ac conductivity is due to both electronic and polaron hopping mechanism.     

Stochastic two-sided U-type assembly line balancing: a genetic algorithm approach

In this paper, a novel stochastic two-sided U-type assembly line balancing (STUALB) procedure, an algorithm based on the genetic algorithm and a heuristic priority rule-based procedure to solve STUALB problem are proposed. With this new proposed assembly line design, all advantages of both two-sided assembly lines and U-type assembly lines are combined. Due to the variability of the real-life conditions, stochastic task times are also considered in the study. The proposed approach aims to minimise the number of positions (i.e. the U-type assembly line length) as the primary objective and to minimise the number of stations (i.e. the number of operators) as a secondary objective for a given cycle time. An example problem is solved to illustrate the proposed approach. In order to evaluate the efficiency of the proposed algorithm, test problems taken from the literature are used. The experimental results show that the proposed approach performs well.     

Coping with production time variability via dynamic lead-time quotation

In this paper, we propose two dynamic lead-time quotation policies in an M/GI/1 type make-to-stock queueing system serving lead-time sensitive customers with a single type of product. Incorporating non-exponential service times in an exact method for make-to-stock queues is usually deemed difficult. Our analysis of the proposed policies is exact and requires the numerical inversion of the Laplace transform of the sojourn time of an order to be placed. The first policy assures that the long-run probability of delivering the product within the quoted lead-time is the same for all backlogged customers. The second policy is a refinement of the first which improves the profitability if customers are oversensitive to even short delays in delivery. Numerical results show that both policies perform close to the optimal policy that was characterized only for exponential service times. The new insight gained is that the worsening impact of the production time variability, which is felt significantly in systems accepting all customers by quoting zero lead times, decreases when dynamic lead-time quotation policies are employed.     

Revealing determinants of two‐phase dynamics of P53 network under gamma irradiation based on a reduced 2D relaxation oscillator model

This study proposes a two‐dimensional (2D) oscillator model of p53 network, which is derived via reducing the multidimensional two‐phase dynamics model into a model of ataxia telangiectasia mutated (ATM) and Wip1 variables, and studies the impact of p53‐regulators on cell fate decision. First, the authors identify a 6D core oscillator module, then reduce this module into a 2D oscillator model while preserving the qualitative behaviours. The introduced 2D model is shown to be an excitable relaxation oscillator. This oscillator provides a mechanism that leads diverse modes underpinning cell fate, each corresponding to a cell state. To investigate the effects of p53 inhibitors and the intrinsic time delay of Wip1 on the characteristics of oscillations, they introduce also a delay differential equation version of the 2D oscillator. They observe that the suppression of p53 inhibitors decreases the amplitudes of p53 oscillation, though the suppression increases the sustained level of p53. They identify Wip1 and P53DINP1 as possible targets for cancer therapies considering their impact on the oscillator, supported by biological findings. They model some mutations as critical changes of the phase space characteristics. Possible cancer therapeutic strategies are then proposed for preventing these mutations’ effects using the phase space approach.Inspec keywords: physiological models, cellular biophysics, cancer, difference equations, delays, enzymes, biochemistry, molecular biophysics, gamma‐rays, radiation therapyOther keywords: two‐phase dynamics model, P53 network, gamma irradiation, 2D relaxation oscillator model, ATM model, Wip1 variables, p53‐regulators, cell fate decision, excitable relaxation oscillator, Wip1 time delay, state‐dependent delay differential equation, cell cycle arrest, cell apoptosis, cancer therapies, Wip1 overexpression, Wip1 downregulation, ATM deficiency, Mdm2 overexpression, Mdm2 downregulation, mutation effects, phase space approach     

Spray-Coating of Superhydrophobic Coatings for Advanced Applications

Superhydrophobic coatings are widely applicable, e.g., as self-cleaning surfaces or water–oil separation membranes, yet their wider usage is impeded due to costs of fabrication, size, or substrate limitation. Spray-coating is a versatile coating procedures and might offer a good solution for the fabrication of these superhydrophobic coatings, due to the fact that coatings can be fabricated on various materials in a simple, fast, and inexpensive manner. Most procedures rely on hybrid coatings of hydrophobized nanoparticles and a polymeric matrix, which have several drawbacks including the easy loss of nanoparticles and difficult waste handling. Here, the fabrication of the superhydrophobic material, called Fluoropor, for the first time, by spray-coating on various substrates including metals, tissues, concrete, and glass is presented. It is fabricated by spray-coating a mixture of a highly fluorinated monomer blended with porogens followed by photopolymerization. The superhydrophobicity of the material relies on the porous structure on the micro-/nanoscale across the bulk material and does not require any nanoparticles. Excellent self-cleaning ability of these coatings, resistance against thermal and abrasive impact, and their application as oil–water separation membranes are shown. This versatile applicability is highly promising for real-world application as self-cleaning coatings or oil–water separating membranes.     

Estimating Construction Material Indices with ARIMA and Optimized NARNETs

Construction Industry operates relying on various key economic indicators. One of these indicators is material prices. On the other hand, cost is a key concern in all operations of the construction industry. In the uncertain conditions, reliable cost forecasts become an important source of information. Material cost is one of the key components of the overall cost of construction. In addition, cost overrun is a common problem in the construction industry, where nine out of ten construction projects face cost overrun. In order to carry out a successful cost management strategy and prevent cost overruns, it is very important to find reliable methods for the estimation of construction material prices. Material prices have a time dependent nature. In order to increase the foreseeability of the costs of construction materials, this study focuses on estimation of construction material indices through time series analysis. Two different types of analysis are implemented for estimation of the future values of construction material indices. The first method implemented was Autoregressive Integrated Moving Average (ARIMA), which is known to be successful in estimation of time series having a linear nature. The second method implemented was Non-Linear Autoregressive Neural Network (NARNET) which is known to be successful in modeling and estimating of series with non-linear components. The results have shown that depending on the nature of the series, both these methods can successfully and accurately estimate the future values of the indices. In addition, we found out that Optimal NARNET architectures which provide better accuracy in estimation of the series can be identified/discovered as result of grid search on NARNET hyperparameters.     

Measures for investigating the contextual modulation of information transmission

The aim of this paper is to show how information theoretic measures can be used to analyse and interpret the results of psychophysical experiments designed to search for conditions under which information from one source modulates the transmission of information from another source. We therefore use measures of mutual and conditional information to analyse systems with two inputs. The information transmitted by such a system can be split into three components depending on whether it is shared between the two inputs or is specific to each. We are concerned here with distinguishing systems that use one input to modulate transmission of information about the other from systems that simply add both inputs, and show how the three components provide evidence for distinguishing between additive and modulatory effects. We also report numerical simulations of the sampling biasses and variances of these measures as a function of the sample size and propose minimum sample sizes that should be used to overcome the bias.