High Resolution Pulse Propagation Driven Trojan Detection in Digital Systems

Journal of Electronic Testing - Outsourcing of IC manufacturing has opened the possibility of intentionally modifying the operation of the IC in a subtle way so that it is extremely difficult to...     

Cancer Vaccines,Treatment of the Future: With Emphasis on HER2-Positive Breast Cancer

Breast cancer is one of the leading causes of death in women. With improvements in early-stage diagnosis and targeted therapies, there has been an improvement in the overall survival rate in breast cancer over the past decade. Despite the development of targeted therapies, tyrosine kinase inhibitors, as well as monoclonal antibodies and their toxin conjugates, all metastatic tumors develop resistance, and nearly one-third of HER2+ breast cancer patients develop resistance to all these therapies. Although antibody therapy has shown promising results in breast cancer patients, passive immunotherapy approaches have limitations and need continuous administration over a long period. Vaccine therapy introduces antigens that act on cancer cells causing prolonged activation of the immune system. In particular, cancer relapse could be avoided due to the presence of a longer period of immunological memory with an effective vaccine that can protect against various tumor antigens. Cancer vaccines are broadly classified as preventive and therapeutic. Preventive vaccines are used to ward off any future infections and therapeutic vaccines are used to treat a person with active disease. In this article, we provided details about the tumor environment, different types of vaccines, their advantages and disadvantages, and the current status of various vaccine candidates with a focus on vaccines for breast cancer. Current data indicate that therapeutic vaccines themselves have limitations in terms of efficacy and are used in combination with other chemotherapeutic or targeting agents. The majority of breast cancer vaccines are undergoing clinical trials and the next decade will see the fruitfulness of breast cancer vaccine therapy.     

Optimization and Effect of Reinforcements on the Sliding Wear Behavior of Self-Lubricating AZ91D-SiC-Gr Hybrid Composites

Silicon - This article statistically investigates the effect of various parameters such as material factors: silicon carbide (SiC) fraction, graphite (Gr) fraction and mechanical factors: normal...     

Nanoindentation based fracture studies of ITO coating

Nano-scale load (P) dependency of fracture toughness (K_1C) of indium tin oxide (ITO) coating on silicon (Si) substrate is evaluated by nanoindentation based direct and energy methods. A Berkovich triangular diamond nanoindenter is used with nine different P values e.g., 10, 15, 20, 30, 40, 50, 100, 150 and 200 mN. Extensive utilization of both optical microscopy (OM) and field emission scanning electron microscopy (FESEM) techniques reveal that up to P ≤ 40 mN only the sharp radial cracks form from three corners of the nanoindent. However, for P > 40 mN, multiple cracks occur over and above the radial cracks. Finally, at P: 150–200 mN coating gets chipped off from the substrate. The K_1C values of the ITO coating are calculated on the basis of both the conventional radial crack length measurement based method and the strain energy release based method. The K_1C values are strongly sensitive to variations in P. Further, the strain energy method results in higher magnitudes of the K_1C values.     

Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System**

Tuberculosis is a global health problem caused by infection with the Mycobacterium tuberculosis (Mtb) bacteria. Although antibiotic treatment has dramatically reduced the impact of tuberculosis on the population, the existence and spreading of drug resistant strains urgently demands the development of new drugs that target Mtb in a different manner than currently used antibiotics. The prokaryotic ubiquitin-like protein (Pup) proteasome system is an attractive target for new drug development as it is unique to Mtb and related bacterial genera. Using a Pup-based fluorogenic substrate, we screened for inhibitors of Dop, the Mtb depupylating protease, and identified I-OMe-Tyrphostin AG538 ( 1 ) and Tyrphostin AG538 ( 2 ). The hits were validated and determined to be fast-reversible, non-ATP competitive inhibitors. We synthesized >25 analogs of 1 and 2 and show that several of the synthesized compounds also inhibit the depupylation actions of Dop on native substrate, FabD-Pup. Importantly, the pupylation activity of PafA, the sole Pup ligase in Mtb, was also inhibited by some of these compounds.     

Delaying Ice and Frost Formation Using Phase‐Switching Liquids

Preventing water droplets from transitioning to ice is advantageous for numerous applications. It is demonstrated that the use of certain phase‐change materials, which are in liquid state under ambient conditions and have melting point higher than the freezing point of water, referred herein as phase‐switching liquids (PSLs), can impede condensation–frosting lasting up to 300 and 15 times longer in bulk and surface infused state, respectively, compared to conventional surfaces under identical environmental conditions. The freezing delay is primarily a consequence of the release of trapped latent heat due to condensation, but is also affected by the solidified PSL surface morphology and its miscibility in water. Regardless of surface chemistry, PSL‐infused textured surfaces exhibit low droplet adhesion when operated below the corresponding melting point of the solidified PSLs, engendering ice and frost repellency even on hydrophilic substrates. Additionally, solidified PSL surfaces display varying degrees of optical transparency, can repel a variety of liquids, and self‐heal upon physical damage.     

Designing a Hadoop system based on computational resources and network delay for wide area networks

Telecommunication Systems - This paper proposes a Hadoop system that considers both slave server’s processing capacity and network delay for wide area networks to reduce the job processing...     

Green media-aware medical IoT system

Rapid proliferation in state-of-the art technologies has revolutionized the medical market for providing urgent, effective and economical health facilities to aging society. In this context media (i.e., video) transmission is considered as a quite significant step during first hour of the emergency for presenting a big and better picture of the event. However, the energy hungry media transmission process and slow progress in battery technologies have become a major and serious problem for the evolution of video technology in medical internet of things (MIoT) or internet of medical things (IoMT). So, promoting Green (i.e., energy-efficient) transmission during voluminous and variable bit rate (VBR) video in MIoT is a challenging and crucial problem for researchers and engineers. Therefore, the need arose to conduct research on Green media transmission techniques to cater the need of upcoming wearable healthcare devices. Thus, this research contributes in two distinct ways; first, a novel and sustainable Green Media Transmission Algorithm (GMTA) is proposed, second, a mathematical model and architecture of Green MIoT are designed by considering a 8-min medical media stream named, ‘Navigation to the Uterine Horn, transection of the horn and re-anastomosis’ to minimize transmission energy consumption in media-aware MIoT, and to develop feasible media transmission schedule for sensitive and urgent health information from physian to patients and vice vers through extremely power hungry natured wearable devices. The experimental results demonstrate that proposed GMTA saves energy up to 41%, to serve the community.