PdCl2(bipy) complex—An efficient catalyst for Heck reaction in glycol–organic biphasic medium

The Palladium complex PdCl₂(bipy) (1) was found to be efficient in catalyzing the Heck reaction of aryl halides in a biphasic system comprising ethylene glycol along with an organic solvent. A proper tailoring of the organic phase ensured that the leaching of the catalyst to the organic phase was negligible. The catalyst was active for the Heck reaction of a number of olefins, aryl halides, in presence of organic and inorganic bases. The PdCl₂(bipy) catalyst was stable and could be recycled for five times without any loss in activity and selectivity. A major advantage of this work is that unlike hitherto reported biphasic systems; it does not employ a water-soluble ligand to achieve biphasic catalysis.     

Dynamic Template Tracking and Recognition

In this paper we address the problem of tracking non-rigid objects whose local appearance and motion changes as a function of time. This class of objects includes dynamic textures such as steam, fire, smoke, water, etc., as well as articulated objects such as humans performing various actions. We model the temporal evolution of the object’s appearance/motion using a linear dynamical system. We learn such models from sample videos and use them as dynamic templates for tracking objects in novel videos. We pose the problem of tracking a dynamic non-rigid object in the current frame as a maximum a-posteriori estimate of the location of the object and the latent state of the dynamical system, given the current image features and the best estimate of the state in the previous frame. The advantage of our approach is that we can specify a-priori the type of texture to be tracked in the scene by using previously trained models for the dynamics of these textures. Our framework naturally generalizes common tracking methods such as SSD and kernel-based tracking from static templates to dynamic templates. We test our algorithm on synthetic as well as real examples of dynamic textures and show that our simple dynamics-based trackers perform at par if not better than the state-of-the-art. Since our approach is general and applicable to any image feature, we also apply it to the problem of human action tracking and build action-specific optical flow trackers that perform better than the state-of-the-art when tracking a human performing a particular action. Finally, since our approach is generative, we can use a-priori trained trackers for different texture or action classes to simultaneously track and recognize the texture or action in the video.     

MOSFET栅氧泄漏隧穿电流的分析模型:量子力学研究(英文)

研发了一种通过MOSFET的超薄栅氧化物分析直接隧穿电流密度的模型。采用Wentzel-Kramers-Brilliouin(WKB)近似计算了隧穿概率,利用清晰的表面势方程改进模型的准确性。在研究模型中考虑了Si衬底中反型层的量子化和多晶硅栅耗尽,还研究了多晶硅掺杂对栅氧化层隧穿电流的影响。仿真结果表明,栅氧化层隧穿电流随多晶硅栅掺杂浓度的增加而增加。该结论与已报道的结果相吻合,从而证明了该模型的正确性。     

Dopingless Impact Ionization MOS (DL-IMOS)- A remedy for complex process flow

We propose a unique approach for realizing dopingless impact ionization MOS (DL-IMOS) based on the charge plasma concept as a remedy for complex process flow. It uses work-function engineering of electrodes to form charge plasma as surrogate doping. This charge plasma induces a uniform p-region in the source side and an n-region in the drain side on intrinsic silicon film with a thickness less than the intrinsic Debye length. DL-IMOS offers a simple fabrication process flow as it avoids the need of ion implantation, photo masking and complicated thermal budget via annealing devices. The lower thermal budget is required for DL-IMOS fabrication enables its fabrication on single crystal silicon-on-glass substrate realized by wafer scale epitaxial transfer. It is highly immune to process variations, doping control issues and random dopant fluctuations, while retaining the inherent advantages of conventional IMOS. To epitomize the fabrication process flow for the proposed device a virtual fabrication flow is also proposed here. Extensive device simulation of the major device performance metrics such as subthreshold slope, threshold voltage, drain induced current enhancement, and breakdown voltage have been done for a wide range of electrodes work-function. To evaluate the potential applications of the proposed device at circuit level, its mixed mode simulations are also carried out.     

Application of genetic algorithms in production and operations management: a review

Over the last decade, there has been a rapid growth of the use of genetic algorithms in the various areas of production and operations management. This paper provides a review of genetic algorithms research published in twenty-one major production and operations management journals from 1990–2001. More specifically, it identifies research trends and publication outlets of genetic algorithms applications. Our findings show that there are only a handful of production and operations management areas to which genetic algorithms have been applied as the solution approach. Furthermore, we recognize and discuss potential research areas and outlets in which researchers may target their work as well as the need for top ranked POM journals to consider publishing genetic algorithms related papers.     

Ultra-low contact resistance of epitaxially interfaced bridged silicon nanowires

Laterally oriented single-crystal silicon nanowires are epitaxially grown between highly doped vertically oriented silicon electrodes in the form of nanobridges. Resistance values extracted from the current-voltage measurements for a large number of nanobridges with varying lengths and diameters are used to propose a model which highlights the relative contribution of the contact resistance to the total resistance for nanowire-based devices. It is shown that the contact resistance depends on the effective conducting cross-section area and hence is influenced by the presence of a surface depletion layer. On the basis of our measured data and constructed model, we estimated the specific contact resistance to be in the range 3.74 x 10(-6) to 5.02 x 10(-6) Omega cm2 for our epitaxial interfacing method. This value is at least an order of magnitude lower than that of any known contact made to nanowires with an evaporated metal film, a common method for integrating semiconductor nanowires in devices and circuits.     

The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses

Twelve subjects were treated with zidovudine, lamivudine, and ritonavir within 90 days of onset of symptoms of acute infection to determine whether human immunodeficiency virus type 1 (HIV-1) infection could be eradicated from an infected host. In adherent subjects, with or without modifications due to intolerance, viral replication was suppressed during the 24-month treatment period. Durable suppression reduced levels of HIV-1-specific antibodies and cytotoxic T lymphocyte responses in selected subjects. Proviral DNA in mononuclear cells uniformly persisted. The persistence of HIV-1 RNA expression in lymphoid tissues and peripheral blood mononuclear cells suggests that elimination of this residual pool of virus should be achieved before considering adjustments in antiretroviral therapeutic regimens. In addition, given the reduction in levels of virus-specific immune responses, it would seem prudent to consider enhancing these responses using vaccine strategies prior to the withdrawal of antiviral therapy.     

Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation

DNA strand breaks with terminal 3'-phosphoglycolate groups are produced by agents that can abstract the hydrogen atom from the 4'-carbon of DNA deoxyribose groups. Included among these agents are gamma-radiation (via the OH radical) and enediyne compounds, such as neocarzinostatin and calicheamicin. However, while the majority of radiation-induced phosphoglycolates are found at single-strand breaks, most of the phosphoglycolates generated by these two enediynes are found at bistranded lesions, including double-strand breaks. Using a 32P-post-labelling assay, we have compared the enzyme-catalyzed removal of phosphoglycolates induced by each of these agents. Both human apurinic/apyrimidinic endonuclease 1 (Ape 1) and its Escherichia coli homolog exonuclease III rapidly removed over 80% of phosphoglycolates from gamma-irradiated DNA, although there appeared to be a small resistant subpopulation. The neocarzinostatin-induced phosphoglycolates were removed more slowly, though not to completion, while the calicheamicin-induced phosphoglycolates were extremely refractory to both enzymes. These data suggest that unless other enzymes are capable of acting upon the phosphoglycolate termini at enediyne-induced double-strand breaks, such termini will be resistant to end rejoining repair pathways.     

Mathematical Modeling of Lake Tap Flows

A lake tap is the submerged piercing of a tunnel at the intake to connect the reservoir to the tunnel system. It is referred to as a dry lake tap if the tunnel is dry before the blasting of the last rock plug at the tunnel entrance. Transient state conditions in the tunnel following a dry lake tap are modeled using the lumped and distributed-system approaches. Fourth-order Runge-Kutta method and the method of characteristics are used in the lumped-system model and distributed-system models, respectively. The results computed by the lumped and distributed-system approaches agree with one another. Pressures computed by using distributed-system and lumped-system models are compared with the experimental results available in literature for rapid filling of a pipeline with closed end. The rate of dissipation of pressure oscillations in the measured air pressure during prototype lake tap at Crater Lake Snettisham project in Alaska, and in the experiments reported in the literature is higher than that computed by the mathematical models using steady state friction and constant wave velocity.     

Phase I and pharmacologic study of paclitaxel and cisplatin with granulocyte colony-stimulating factor: neuromuscular toxicity is dose-limiting

PURPOSE: To determine the maximum-tolerated doses (MTD), the principal toxicities, and the pharmacologic behavior of high doses of Taxol (paclitaxel; Bristol-Myers Squibb, New York, NY) combined with cisplatin and granulocyte colony-stimulating factor (G-CSF). PATIENTS AND METHODS: Untreated and minimally pretreated solid-tumor patients received 24-hour infusions of Taxol on day 1 followed by cisplatin on day 2 and G-CSF, 5 micrograms/kg/d subcutaneously (SC), beginning on day 3. Treatment was repeated every 3 weeks. Starting doses of Taxol and cisplatin were 135 and 75 mg/m2, respectively. RESULTS: The development of a severe peripheral neuropathy and/or severe myalgias precluded the chronic administration of Taxol and cisplatin with G-CSF at doses greater than 250 mg/m2 and 75 mg/m2, respectively. At this dose, the mean Taxol steady-state plasma concentration (Css) exceeds concentrations capable of inducing pertinent antimicrotubule effects in vitro. The severity of the neuropathy was related to the cumulative dose of Taxol, the magnitude of the dose administered during each treatment, and the presence of a pre-existing medical disorder associated with peripheral neuropathy. A proximal myopathy of modest severity also was documented. Although severe neutropenia occurred frequently, especially at the MTD, it was rarely associated with fever (8% of courses), and absolute neutrophil counts (ANCs) less than 500/microL never persisted for more than 5 days. Responses were noted in non-small-cell lung cancer (NSCLC) and head and neck, breast, and esophageal cancers. CONCLUSION: Taxol and cisplatin doses of 250 mg/m2 and 75 mg/m2, respectively, can be administered repetitively with G-CSF to untreated and minimally pretreated patients. However, these doses are not recommended for patients with pre-existing neuropathies until additional experience in high-risk patients is obtained. Although this Taxol dose is nearly 85% higher than the dose that can be combined with cisplatin in the absence of G-CSF, this high-dose regimen should not be used outside the investigational setting until a dose-response relationship has been demonstrated for Taxol in randomized clinical trials.