Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect

The low-density-lipoprotein receptor (LDLr) removes low-density lipoprotein (LDL), an endovascular transporter that carries cholesterol from the bloodstream to peripheral tissues. The maintenance of cholesterol content in the brain, which is important to protect brain function, is affected by LDLr. LDLr co-localizes with the insulin receptor and complements the internalization of LDL. In LDLr deficiency, LDL blood levels and insulin resistance increase, leading to abnormal cholesterol control and cognitive deficits in atherosclerosis. Defects in brain cholesterol metabolism lead to neuroinflammation and blood–brain-barrier (BBB) degradation. Moreover, interactions between endoplasmic reticulum stress (ER stress) and mitochondria are induced by ox-LDL accumulation, apolipoprotein E (ApoE) regulates the levels of amyloid beta (Aβ) in the brain, and hypoxia is induced by apoptosis induced by the LDLr defect. This review summarizes the association between neurodegenerative brain disease and typical cognitive deficits.     

对一类逆变器的数学模型和等效结构图的探讨

本文在特定条件下，通过对阶跃输入下ＦｖＲＯ１５Ｇ７Ｓ－４ＥＸ输出响应特性的分析和实际观测，提出了它的传递函数的数学模型和等效结构图。     

Improved digital image processing technique to investigate plastic zone formation in steel

An improved digital image processing procedure is developed to extract the size and shape of the plastic zone formation at the tip of a notched metal specimen based on the characteristics of the variation of intensity in a digitized image. The result is compared with the result from finite element analysis, and with that from a previously developed image processing procedure. Comparison shows that this method provides a faster and more accurate result than previously.     

P2P computing for intelligence of things

Peer-to-Peer Networking and Applications -     

Superior–Subordinate Relationships in Korean Civil Engineering Companies

The Leader–Member Exchange (LMX) relationship quality between superiors and subordinates in Korean civil engineering companies were empirically examined for superiors’ feedback-seeking behaviors. The results showed that for superiors, affect, loyalty, and contribution toward subordinates were positively related to seeking negative as well as positive feedback from subordinates. From subordinates’ point of view, affect, contribution, and professional respect toward their superiors were positively related to superiors’ negative feedback seeking, but affect was negatively related to superiors’ positive feedback seeking. It was also found that superiors and subordinates were not consensual in LMX and superiors’ feedback-seeking behaviors. For example, for superiors, all of the four LMX dimensions were positively related to superiors’ asking subordinates directly for feedback, whereas for subordinates, none of the LMX dimensions were significantly related to superiors’ asking subordinates directly for feedback. These and other findings are discussed in detail, and implications for the findings are provided.     

Further result on a dynamic recurrent neural-network-based adaptive observer for a class of nonlinear systems

In Kim et al. [(1997) A dynamic recurrent neural-network-based adaptive observer for a class of nonlinear systems. Automatica 33(8), 1539–1543], authors present an excellent neural network (NN) observer for a class of nonlinear systems. However, the output error equation in their paper is strictly positive real (SPR) which is restrictive assumption for nonlinear systems. In this note, by introducing a vector b₀ and Lyapunov equation, the observer design is obtained without requiring the SPR condition. Thus, our observer can be applied to a wider class of systems.     

Polymeric (SU-8) optical microscanner driven by electrostatic actuation

A torsional micromechanical scanner was fabricated using photosensitive polymer (SU-8). The proposed polymer-based optical microscanner with reduced torsional stiffness offers a new approach to increase scanning angles. The scanner consists of two parts; the top layer (micro mirror and electrodes) and the bottom layer (anchors and electrodes). The SU-8 scanner is actuated by electrostatic force generated by gap-closing electrodes. For the fabricated optical scanner with the mirror size of 3 × 3 mm², the experimentally obtained scanning angles were 0.43° for 60 Hz (non-resonant) and 1.54° for 1.13 kHz (resonant) at the input voltage of 160 V. This paper also proposes a simple and new fabrication method, which can effectively control the stiffness of the torsional springs by molding SU-8 photoresist through V-groove on the silicon substrate, thereby increasing the scanning angles.     

The Use of Distinctive Monoclonal Antibodies in FMD VLP- and P1-Based Blocking ELISA for the Seromonitoring of Vaccinated Swine

The serum neutralization (SN) test has been regarded as the “gold standard” for seroconversion following foot-and-mouth disease virus (FMDV) vaccination, although a high-level biosafety laboratory is necessary. ELISA is one alternative, and its format is constantly being improved. For instance, standard polyclonal antisera have been replaced by monoclonal antibodies (MAbs) for catching and detecting antibodies, and inactive viruses have been replaced by virus-like particles (VLPs). To the best of current knowledge, however, no researchers have evaluated the performances of different MAbs as tracers. In previous studies, we successfully identified site 1 and site 2 MAbs Q10E and P11A. In this study, following the established screening platform, the VLPs of putative escape mutants from sites 1 to 5 were expressed and used to demonstrate that S11B is a site 3 MAb. Additionally, the vulnerability of VLPs prompted us to assess another diagnostic antigen: unprocessed polyprotein P1. Therefore, we established and evaluated the performance of blocking ELISA (bELISA) systems based on VLPs and P1, pairing them with Q10E, P11A, S11B, and the non-neutralizing TSG MAb as tracers. The results indicated that the VLP paired with S11B demonstrated the highest correlation with the SN titers (R² = 0.8071, n = 63). Excluding weakly positive serum samples (SN = 16–32, n = 14), the sensitivity and specificity were 95.65% and 96.15% (kappa = 0.92), respectively. Additionally, the P1 pairing with Q10E also demonstrated a high correlation (R² = 0.768). We also discovered that these four antibodies had steric effects on one another to varying degrees, despite recognizing distinct antigenic sites. This finding indicated that MAbs as tracers could not accurately detect specific antibodies, possibly because MAbs are bulky compared to a protomeric unit. However, our results still provide convincing support for the application of two pairs of bELISA systems: VLP:S11B-HRP and P1:Q10E-HRP.     

A new optimal digital halftoning technique based on the discrete cosine transform

Digital halftoning is a technique to display a gray-level image with a bilevel device. Conventionally, most halftoning techniques are done in the spatial domain. A new halftoning technique based on the discrete cosine transform is proposed. The method chooses an optimal bilevel image to display the original gray-level image and minimize the weighted mean square error based on the discrete cosine transform domain. The simulation results indicate that our algorithm can produce very good halftoned images without false contours.