Crystalline selenite substituted carbonated hydroxyapatite nanorods: Synthesis,characterization, evaluation of bioactivity and cytotoxicity

Synthesis of pure and selenite substituted hydroxyapatites (HAP and Se‐HAP with 0.02–0.10 Se) by sol–gel method and evaluation of their morphological features, nature of functional groups, phase purity, in vitro bioactivity and cytotoxicity are addressed. Spectral studies confirm the incorporation of selenite into the HAP lattice, accompanied by an increase in CO₃^2? content to maintain the charge imbalance following replacement of P⁵⁺ with Se⁴⁺, thus making the formation of selenite substituted carbonated HAP. Selenite substitution in the HAP lattice has led to a higher crystallinity and increased the crystallite size. The morphology of HAP is changed from sphere to rod‐like structure upon substitution by selenite and the size of the rod is increased with an increase in the selenite content. Among the Se‐HAPs, a better in vitro bioactivity and cell viability are observed for 0.02 Se‐HAP and 0.04 Se‐HAP while the trend is reversed when the extent of selenite substitution becomes higher.     

Superparamagnetic Nanostructures for Off‐Resonance Magnetic Resonance Spectroscopic Imaging

This study proposes a new method to generate positive contrast in magnetic resonance imaging (MRI) using superparamagnetic contrast agents. Superparamagnetic nanostructures consisting of octahedron manganese ferrite nanoparticles embedded in spherical nanogels are fabricated using a bottom‐up approach. The composite nanoparticles are strongly magnetized in an external magnetic field and produce a unique NMR frequency shift in water protons, which can be demonstrated in MR spectroscopy and imaging to be different from the bulk pool. Moreover, the particles exhibit excellent colloidal stability in aqueous media and good cell biocompatibility. Hence, these particles are potentially useful as biomarkers by taking advantage of the positive contrast effects produced in MRI.     

Evolution of supramolecular healable composites: a minireview

Efforts to further extend the range of applications of polymer based materials have resulted in the recent production of healable polymers that can regain their strength after damage. Within this field of healable materials, supramolecular polymers have been subject to extensive investigation. By virtue of their reversible non‐covalent interactions, cracks and fractures in such polymers can be readily and repeatedly healed in order to regain key physical properties. However, many supramolecular polymers are relatively weak and elastomeric in nature, which renders them unsuitable for high strength structural applications. To overcome these deficiencies, preliminary studies have shown that it is possible to reinforce supramolecular polymers with microscale and nanoscale fillers to afford composites that are not only stronger and stiffer compared with the polymers alone but also retain their healing abilities. In this minireview we discuss the evolution of these supramolecular composites and their advantages over more conventional, covalent polymeric materials. © 2014 Society of Chemical Industry     

Synthesis and optical characteristics of ZnO nanocrystals

Zinc oxide nanomaterials with an average particle size of 20–30 nm are readily synthesized by the reaction of zinc acetate and oxalic acid under hydrothermal conditions. The samples are characterized by XRD, SEM, TEM, UV and photoluminescence (PL) studies. The average crystal size of the as prepared ZnO nanopowder is determined by XRD and the values are in good agreement with the TEM analysis. UV absorption spectra revealed the absorption at wavelength < 370 nm indicating the smaller size of ZnO nanoparticles. The quality and purity of ZnO nanomaterial crystalline samples are confirmed by photoluminescence spectra.     

Analytical model for Binding Refresh Request to reduce storage and communication overhead in MIPv6 network

Home agent is a key component of MIPv6 functionality that comprises binding cache to hold the mobile nodes current point of attachment to the Internet. This paper is concerned with binding cache support for home agents within MIPv6 network. Existing binding cache of home agent supports weak cache consistency by using fixed contract length for Binding Refresh Request, which functions reasonably well in normal situations. However, maintaining a strong binding cache consistency in home agent as a crucial exceptional handling mechanism has become more demanding for the following objectives: (i) to adapt increasingly frequent change of care‐of address due to mobile nodes movement detection update; (ii) to provide fine‐grain controls to balance the binding cache load distributions for better delivery services; and (iii) to reduce the overhead allowances around the binding cache. In this paper, we have first verified the effectiveness of Binding Refresh Request contract length, and on the basis of that, two dynamic contract algorithms are suggested to reduce the storage and communication overhead allowances in binding cache. We have also compared our technique with the existing fixed Binding Refresh Request contract length, and our simulation results reveals that the proposed approach provides an effective performance to reduce overhead within the network. Copyright © 2014 John Wiley & Sons, Ltd.     

Detection of glucose,galactose, and lactose in milk with a microdialysis-coupled flow injection amperometric sensor

A microdialysis-coupled flow injection amperometric Sensor (microFIAS) was used to determine glucose, galactose, and lactose in milk. The sensor is based on enzyme-catalyzed reaction in combination with the three well-established analytical techniques, namely; microdialysis sampling, flow injection analysis (FIA), and amperometric detection. With the multianalyte sensor it was possible to detect glucose and galactose by sequential injection of their corresponding oxidase enzymes: glucose oxidase and galactose oxidase, while lactose was determined by injection of a mixture of beta-galactosidase and glucose oxidase enzymes. The sensor showed a linear response between 0.05 and 10 mM for glucose, between 0.1 and 20 mM for galactose and between 0.2 and 20 mM for lactose, respectively. The relative standard deviation values of the sensor measurements for glucose, galactose, and lactose were 3-4% (n = 3). The sensor measurements for lactose content in milk were compared with a standard method with an infrared spectrophotometer.     

Finite-horizon scheduling of radar dwells with online template construction

Timing constraints for radar tasks are usually specified in terms of the minimum and maximum temporal distance between successive radar dwells. We utilize the idea of feasible intervals for dealing with the temporal distance constraints. In order to increase the freedom that the scheduler can offer a high-level resource manager, we introduce a technique for nesting and interleaving dwells online while accounting for the energy constraint that radar systems need to satisfy. Further, in radar systems, the task set changes frequently and we advocate the use of finite horizon scheduling in order to avoid the pessimism inherent in schedulers that assume a task will execute forever. The combination of feasible intervals and online dwell packing allows modular schedule updates whereby portions of a schedule can be altered without affecting the entire schedule, hence reducing the complexity of the scheduler. Through extensive simulations we validate our claims of providing greater scheduling flexibility without compromising on performance when compared with earlier work based on templates constructed offline. We also evaluate the impact of two parameters in our scheduling approach: the template length (or the extent of dwell nesting and interleaving) and the length of the finite horizon. Sathish Gopalakrishnan is a visting scholar in the Department of Computer Science, University of Illinois at Urbana-Champaign, where he defended his Ph.D. thesis in December 2005. He received an M.S. in Applied Mathematics from the University of Illinois in 2004 and a B.E. in Computer Science and Engineering from the University of Madras in 1999. Sathish’s research interests concern real-time and embedded systems, and the design of large-scale reliable systems. He received the best student paper award for his work on radar dwell scheduling at the Real-Time Systems Symposium 2004. Marco Caccamo graduated in computer engineering from the University of Pisa in 1997 and received the Ph.D. degree in computer engineering from the Scuola Superiore S. Anna in 2002. He is an Assistant Professor of the Department of Computer Science at the University of Illinois. His research interests include real-time operating systems, real-time scheduling and resource management, wireless sensor networks, and quality of service control in next generation digital infrastructures. He is recipient of the NSF CAREER Award (2003). He is a member of ACM and IEEE. Chi-Sheng Shih is currently an assistant professor at the Graduate Institute of Networking and Multimedia and Department of Computer Science and Information Engineering at National Taiwan University since February 2004. He received the B.S. in Engineering Science and M.S. in Computer Science from National Cheng Kung University in 1993 and 1995, respectively. In 2003, he received his Ph.D. in Computer Science from the University of Illinois at Urbana-Champaign. His main research interests are embedded systems, hardware/software codesign, real-time systems, and database systems. Specifically, his main research interests focus on real-time operating systems, real-time scheduling theory, embedded software, and software/hardware co-design for system-on-a-chip. Chang-Gun Lee received the B.S., M.S. and Ph.D. degrees in computer engineering from Seoul National University, Korea, in 1991, 1993 and 1998, respectively. He is currently an Assistant Professor in the Department of Electrical Engineering, Ohio State University, Columbus. Previously, he was a Research Scientist in the Department of Computer Science, University of Illinois at Urbana-Champaign from March 2000 to July 2002 and a Research Engineer in the Advanced Telecomm. Research Lab., LG Information & Communications, Ltd. from March 1998 to February 2000. His current research interests include real-time systems, complex embedded systems, QoS management, and wireless ad-hoc networks. Chang-Gun Lee is a member of the IEEE Computer Society. Lui Sha graduated with the Ph.D. degree from Carnegie-Mellon University in 1985. He was a Member and then a Senior Member of Technical Staff at Software Engineering Institute (SEI) from 1986 to 1998. Since Fall 1998, he has been a Professor of Computer Science at the University of Illinois at Urbana Champaign, and a Visiting Scientist of the SEI. He was the Chair of IEEE Real Time Systems Technical Committee from 1999 to 2000, and has served on its Executive Committee since 2001. He was a member of National Academy of Science’s study group on Software Dependability and Certification from 2004 to 2005, and is an IEEE Distinguished Visitor (2005 to 2007). Lui Sha is a Fellow of the IEEE and the ACM.     

Nonliposomal approach--a study of preparation of egg albumin nanospheres containing amphotericin-B

The stability of liposomes after introduction into the body is presently being discussed and needs thorough understanding. Hence, as a nonliposomal approach, egg albumin nanospheres were prepared by the pH-coacervation method, and a preliminary study was carried out of the influence of process variables on the size and shape of nanospheres by changing the pH of the albumin solution, concentration of albumin solution, and volume of cross-linking agent. The batch prepared with an albumin medium of pH 9, 2% concentration, and 100 μl of 4% glutaraldehyde-ethanol solution was found to have a spherical uniform shape with an average size of 497.6 nm. The ideal batch was loaded with the systemic antifungal drug amphotericin-B. Drug-loaded nanospheres were evaluated to study their in vitro release. They were found to exhibit a biphasic pattern with a cumulative percentage release of 97.7%.     

In situ synthesised TiO2 ‐chitosan‐chondroitin 4–sulphate nanocomposites for bone implant applications

The artificial materials for bone implant applications are gaining more importance in the recent years. The series titania‐chitosan‐chondroitin 4–sulphate nanocomposites of three different concentrations (2:1:x, where x ‐ 0.125, 0.25, 0.5) have been synthesised by in situ sol–gel method and characterised by various techniques. The particle size of the nanocomposites ranges from 30–50 nm. The bioactivity, swelling nature, and the antimicrobial nature of the nanocomposites were investigated. The swelling ability and bioactivity of the composites is significantly greater and they possess high zone of inhibition against the microorganisms such as Staphylococcus aureus and Escherichia coli. The cell viability of the nanocomposites were evaluated by using MG‐63 and observed the composites possess high cell viability at low concentration. The excellent bioactivity and biocompatibility makes these nanocomposites a promising biomaterial for bone implant applications.Inspec keywords: titanium compounds, filled polymers, nanocomposites, bone, orthopaedics, biomedical materials, sol‐gel processing, nanofabrication, particle size, swelling, microorganisms, cellular biophysics, nanomedicine, prostheticsOther keywords: in situ synthesised TiO₂ ‐chitosan‐chondroitin 4‐sulphate nanocomposites, bone implant applications, artificial materials, in situ sol‐gel method, particle size, swelling nature, antimicrobial nature, microorganisms, Staphylococcus aureus, Escherichia coli, cell viability, MG‐63, biomaterial, size 30 nm to 50 nm, TiO₂      

Process Parameter Optimization in Jatropha Methyl Ester Yield Using Taguchi Technique

Among all alternate fuel sources available, the biodiesel of Jatropha curcas appears to be a potential fuel as it widely exists in Asia. The Jatropha methyl ester (JME) is produced by transesterification process. In the transesterification process, alkyl group of ester exchanges with that of an alcohol. This work focuses on optimizing various parameters like quantities of methanol, KOH, and stirrer speed, which influence high JME yield. Based on L₉ orthogonal array, experiments are conducted by using Taguchi technique. All the nine combinations of L₉ orthogonal array are experimentally done for extraction of JME, and then it is used for analysis in Taguchi technique. The analysis of maximum yield is done on the basis of “larger is better” signal to noise ratio (S/N ratio). The best combination in the L₉ orthogonal array is found to be methanol (110 ml), KOH (1.306 gm), and stirrer speed (1200 rpm). The influence of methanol, KOH, and stirrer speed on the yield is found by analysis of variance (ANOVA). Based on the results of ANOVA, it is found that the influence of methanol, KOH, and stirrer speed on the yield are obtained as 70.10%, 20.35%, and 5.78%, respectively.