准噶尔盆地车排子地区侏罗系层序地层格架

在前人对准噶尔盆地全盆地或局部层序地层大量研究成果的基础上，重点对盆地西北缘侏罗系地层格架特征开展了深入、细致的解剖和刻划，建立了层序地层格架，首次对车排子地区侏罗系层序及体系域界面特征进行了描述，并结合钻探井资料，划分了有利的沉积相带，对盆地侏罗系隐蔽型圈闭和油气藏的勘探提供了一种思想和方法。     

低速非线性渗流试井分析理论研究

低渗透油气藏存在不符合达西定律的渗流，从大量实验和产生低速非达西渗流的影响因素分析，低渗透油气藏确定存在启动压力。鉴于此，提出了准确描述含启动压力梯度非达西渗流的试井分析数学模型及模型的解，研究制作了非达西渗流的内、外边界条件下的典型样板曲线，该样板曲线对试井分析解释提供了可靠的帮助，为正确认识和研究低渗透油气藏的特殊规律提供了一个好的方法。     

解放前我国学者对新疆石油地质的调查和研究

20世纪初，随着近代地质学在中国的形成和发展，一些学者开始了对新疆石油地质的调查和研究，30年代末以前，翁文灏，章鸿钊等学者利用文献和间接获得的资料，对新疆石油资源进行了宏观考察和若干重要油苗的地质研究；40年代开始，黄汲清等地质家在新疆进行实地考察，对独山子油田进行了详细研究，并在南北疆部分地区进行了路线性石油地质调查。     

大庆油田杏1-3区三次加密试验区剩余油分布研究

通过对试验区近年完钻的检查井各单砂层水淹状况及其影响因素的分析。利用神经网络模式识别方法建立起单层剩余油识别模型，在此基础上对三次加密试验区各小层剩余油分布进行研究，总结出各类油层剩余油分布特征及成因类型，并分析了试验区剩余油潜力分布，从而为三次加密布井及射孔方案编制提供了可靠的依据。     

构造作用对油气生成和运聚的影响

有机质从埋藏开始，就处于极其复杂的地球物理化学场中，环境提的能量，一是热量，二是机械能，机械能，主要是通过机械力作用传递给系统的，另外还以机械波的形式赋予系统一定的机械能。当发生断褶构造运动时，机械力对油气运移的影响尤为突出，它经能量的迁移转化，促成了包括机械力降解和地应力驱动等一系列的连锁反应，制造了一次次高效的成油（生运）事件，本文以突变论为着眼点，按照改造控制建造的思路，大胆提出构造运动制造生排烃事件，成就含油气系统的假说。     

塔里木盆地英吉苏凹陷中生界油气勘探潜力

塔里木盆地英吉苏凹陷中生界发育有煤系生油岩,其丰度指标与邻区已出油的库车坳陷、吐哈,焉耆盆地有良好可比性,碳质泥岩和煤层中有丰富－较丰富的基质镜质体,树脂体等富氢生烃组分发育。推测侏罗系还有一定范围的开阔水体有机相存在,具备良好的生烃基础。凹陷热演化与吐哈盆地台参１井十分相似,预计在４０００ｍ以下烃源岩已大量成熟,钻井揭示凹陷内中生界有过大规模的油气运移过程,碳同位素分析表明这些油气来自于中生界三     

Prevalence and predictors of sexual dysfunction in long-term survivors of marrow transplantation

PURPOSE: To describe the prevalence of sexual difficulties in men and women after marrow transplantation (MT), and to define medical, demographic, sexual, and psychologic predictors of sexual dysfunction 3 years after MT. PATIENTS AND METHODS: Four hundred seven adult MT patients were assessed pretransplantation. Survivors repeated measures of psychologic and sexual functioning at 1 and 3 years posttransplantation. RESULTS: Data were analyzed from 102 event-free 3-year survivors who defined themselves as sexually active. Men and women did not differ in sexual satisfaction pretransplantation. At 1 and 3 years posttransplantation, women reported significantly more sexual dysfunction than men. Eighty percent of women and 29% of men reported at least one sexual problem by 3 years after MT. No pretransplantation variables were significant predictors of 3-year sexual satisfaction for women. For men, pretransplantation variables of older age, poorer psychologic function, not being married, and lower sexual satisfaction predicted sexual dissatisfaction at 3 years (R2=.28; P < .001). Women who were more dissatisfied 3 years after MT did not receive hormone replacement therapy (HRT) at 1 -year posttransplantation and were less satisfied at 1 year, but not pretransplantation (R2=.35; P < .001). CONCLUSION: Sexual problems are significant in the lives of MT survivors, particularly for women. Although HRT before 1 year posttransplantation improves sexual function, it does not ensure sexual quality of life. Intervention for women is needed to apply hormonal, mechanical, and behavioral methods to prevent sexual difficulties as early after transplantation as possible.     

A transgenic mouse model for mammary carcinogenesis

Missense mutations in the p53 tumor suppressor occur frequently in human breast cancer and influence both the prognosis and response to chemotherapy. Amino acid 175 (equivalent to murine 172) is the second most common site of missense mutations in p53 in human breast cancer. Over 95% of these mutations are arginine-to-histidine (R-H) substitutions resulting in a gain-of-function, and not merely a dominant-negative phenotype. Transgenic mice expressing a p53 172(R-H) construct targeted to the mammary gland by means of a whey acidic protein (WAP) promoter were characterized as a model system in order to determine the specific effects of this mutation on mammary tumorigenesis. Although transgene expression alone had no apparent effect on normal mammary development, transgenic mice treated with the chemical carcinogen dimethylbenz(a)anthracene developed tumors with much shorter latency than did control littermates and had a greater tumor burden. Tumors arising in transgenic mice did not exhibit either decreased apoptosis or increased cell proliferation relative to tumors arising in nontransgenic littermates, but did display increased genomic instability. Large pleiomorphic nuclei were visible in many tumors from transgenic mice, and DNA flow analysis confirmed the presence of significant aneuploid cell populations. Since these transgenic mice develop very few spontaneous tumors, while accelerating carcinogen-and oncogene-mediated tumorigenesis, this mouse model will, therefore, be useful in the investigation of early events in mammary tumorigenesis. It may also be used as a preclinical model to test newly developed chemotherapeutic strategies.     

Pneumococci stimulate the production of the inducible nitric oxide synthase and nitric oxide by murine macrophages

The role of nitric oxide (NO) in the pathophysiology of gram-positive sepsis is uncertain. In inflammatory conditions, high-output NO production is catalyzed by the enzyme inducible nitric oxide synthase (iNOS). The ability of 2 strains of pneumococci, pneumococcal cell wall preparations, and purified pneumococcal capsule (Pnu-Imune 23) to trigger the production of iNOS protein and NO in RAW 264.7 murine macrophages was tested. Live pneumococci, oxacillin-killed pneumococci, and pneumococcal cell wall preparations stimulated the production of iNOS and NO by RAW 264.7 cells in the presence, but not the absence, of low concentrations of recombinant murine interferon-gamma. In contrast, purified pneumococcal capsule induced little or no iNOS or NO production by these cells. Thus, pneumococci stimulate high-output NO production by murine macrophages. The potential role of NO in the pathogenesis of pneumococcal sepsis deserves further study.     

The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions

The alcohol-deprivation effect (ADE) was examined under 4-hr operant and 24-hr free-choice alcohol access in the alcohol-preferring (P) rat after deprivation intervals from 2 to 4 weeks. Results indicated that adult male P rats responding for 6 weeks on a concurrent FR-5/FR-1 schedule of reinforcement for alcohol and water, respectively, and then deprived of alcohol for 2 weeks, demonstrated a 40% increase in alcohol responding during the first 60 min of alcohol reinstatement. The alcohol deprivation effect was temporary, however, as responding did not differ from baseline levels on the second day of reinstatement. In a second experiment, weanling male and female P rats received 7 weeks of continuous access to alcohol, beginning at 21 days of age, and were then deprived of alcohol for 4 weeks. On the first day of alcohol reinstatement, P rats exhibited a 40% to 45% increase from baseline alcohol drinking levels, with alcohol intake returning to baseline levels by the 3rd day of reinstatement. Although alcohol intake was higher in females than in males when adjustment was made for body weight, there were no gender differences in the magnitude of the alcohol deprivation effect. Taken together, these results indicate that the ADE is a long-lasting phenomenon that occurs under both operant and continuous access conditions in the P rat, and thus these rats may be useful models for the study of factors involved in relapse of alcohol drinking.