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991.
A hydraulic calcium phosphate cement made of beta-tricalcium phosphate [beta-Ca3(PO4)2], monocalcium phosphate monohydrate [Ca(H2PO4)2-H2O], and water was used as a delivery system for the antibiotic gentamicin sulfate (GS). GS, added as powder or as aqueous solution, was very beneficial to the physicochemical properties of the cement. The setting time increased from 2 to 4.5 min with 3% (w/w) GS and then slowly decreased to 3.75 min with 16% (w/w) GS. The tensile strength increased from 0.4 to 1.6 MPa with 16% (w/w) GS. These effects were attributed to the presence of sulfate ions in GS. The release of GS from the cement was measured in a pH 7.4 phosphate-buffered saline solution at 37 degrees C by USP paddle method. Factors such as cement porosity, GS content and presence of sulfate ions or polymeric additives were investigated. The amount of GS released was roughly proportional to the square root of time up to approximately 50% release. Afterwards, the release rate markedly slowed down to zero. In all but two cement formulations, the total dose of GS was released within 7 days, indicating that no irreversible binding occurred between the cement paste and the antibiotic. When small amounts of hydroxypropylcellulose or poly(acrylic acid) were added to the cement, the maximum fraction released was a few percent lower than the total GS dose, suggesting some binding between the polymer and GS. The GS release rate was strongly influenced by the presence of sulfate ions in the cement paste and by the cement porosity. The higher the sulfate ion content of the cement paste, the lowe the GS release rate. This influence was attributed to the finer cement micro-structure induced by the presence of sulfate ions. Furthermore, when the initial cement porosity was increased from 38 to 69%, the release rate almost tripled (0.16 to 0.45 h-1/2). Finally, the biological activity of GS in the cement was maintained, as measured by assaying the release medium. 相似文献
992.
利用不同时期成像的航卫片资料,圈定和寻找北淮阳金寨-霍山地区火山机构,结合地面验证,研究火山活动的空间展布规律,以及火山机构的成矿控矿作用。 相似文献
993.
994.
一种铁氧体移相驱动器专用集成电路 总被引:1,自引:1,他引:0
介绍了SA018铁氧体移相驱动器专用集成电路的工作原理,电路设计和实验结果。该电路的内部电路设计有双路激励驱动器,放大器,积分器和双路高速比较器等功能单元。将铁氧体移相器的激励驱动器和相位控制器融于一体,大大减少了铁氧体移相器的外围设计。 相似文献
995.
获得了一种研究碲镉汞深能级的方法。通过分析迁移率 载子浓度与温度的关系,可以得到关于深能级的重要依据。 相似文献
996.
DJ Li K Ohsaki K Ii Q Ye Y Nobuto S Tenshin T Takano-Yamamoto 《Canadian Metallurgical Quarterly》1997,111(8):702-706
The present study evaluates histological characteristics of the soft tissue response to long-term implantation of Apaceram discs composed of dense hydroxyapatite in rats. Discs were implanted into the subcutaneous tissue of 76 rats for six to 20 months. Decalcified histological sections stained with haematoxylin and eosin (H & E) and Mallory's azan were examined. Different cell types surrounding implants were counted. The greatest proportion of macrophages was found at six months (13.5 per cent). This proportion gradually decreased to four per cent at 20 months. Small numbers of lymphocytes and foreign body giant cells were observed in every group, but neither neutrophils nor osteogenesis were observed in any specimens. Results of the present study and previous related studies indicate that despite reappearance of a small number of macrophages six months after implantation, Apaceram is useful for reconstructive surgery. 相似文献
997.
对裂隙岩体中掏糟爆破布孔的影响因素进行了研究,并根据裂分布的情况提出相应的布孔方法和原则。对有关的工程施工具有实际意义。 相似文献
998.
Gong-Liang Li Ishihara Tatsumi Moro-oka Yoshihiko Takita Yusaku 《Applied catalysis. B, Environmental》1996,9(1-4):239-249
The catalytic decomposition of CHClF2 was studied over various acidic metal oxides in a fixed-bed reactor. The Cr2O3ZrO2 exhibited the highest activity. The presence of water vapor in the reaction system suppresses the transformation of oxides to fluorides, progresses the formation of CO2, and it improves the catalysts life. 相似文献
999.