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101.
EIu Dorofeeva VA Gorshkov VV Chestukhin VV Lyskovtsev AB Bezprozvanny? ED Avde?chuk GV Kesarev OM Lazutina VN Nesvetov AE Radzevich 《Canadian Metallurgical Quarterly》1997,69(8):17-19
Therapeutic and prophylactic antiarrhythmic efficacy of sotalol hydrochloride (Sotahexal, "Hexal", Germany) and its effects in intracardiac hemodynamics and ECG parameters were evaluated in 95 patients with ischemic heart disease (IHD). The highest response to the drug was observed in ventricular extrasystoles, arterial flutter and fibrillation. Acute episodes of arrhythmia are managed by bolus administration of Sotahexal [correction of Hexal]. In this case greater risk of side effects exists. It is desirable to decide on the drug dose, mode of administration on the individual basis with due consideration of the risks and dangers which could be avoided in case of adequate instrumental control. 相似文献
102.
GV Kulikov 《Canadian Metallurgical Quarterly》1997,(2):27-28
In patients with pulmonary tuberculosis, intestinal dysbacteriosis has clinical and bacteriological features characterized by the short-age of bifidobacteria (in 88-92%), by changes in the composition of Escherichia coli strains (in 38-42%), by the presence of Candida (in 58-62%), Proteus in half the patients, and by associated dysbacteriosis. Most (75%) patients show Stage III-IV intestinal dysbiosis formed after 3-4 months of continuous chemotherapy. There is a direct relationship between the magnitude of dysbiotic disorders and the duration of chemotherapy. 相似文献
103.
The methods for improving arc striking with wires of minor diameter and for ensuring the weld formation at a current of 10 A with minimum melting and spatter losses are considered. 相似文献
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RB Cain P Fortnagel S Hebenbrock GW Kirby HJ McLenaghan GV Rao S Schmidt 《Canadian Metallurgical Quarterly》1997,238(1):197-201
Vitamin E is one of the most important lipid-soluble antioxidant nutrients. Severe vitamin E deficiency can have a profound effect on the central nervous system. Cystic fibrosis, chronic cholestatic liver disease, abetalipoproteinemia, short bowel syndrome, isolated vitamin E deficiency syndrome and other malabsorption syndromes all may cause varying degrees of neurologic deficits due to related vitamin deficiencies. The classic abnormalities in vitamin E deficiency progress from hyporeflexia, ataxia, limitations in upward gaze and strabismus to long-tract defects, profound muscle weakness and visual field constriction. Patients with severe, prolonged deficiency may develop complete blindness, dementia and cardiac arrhythmias. Treatment must be tailored to the underlying cause of vitamin E deficiency and may include oral or parenteral vitamin supplementation. The more advanced the deficits, the more limited the response to therapy. Therefore, a good neurologic examination and periodic serum vitamin E levels are essential in patients at risk of vitamin E deficiency. 相似文献
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P Pushko M Parker GV Ludwig NL Davis RE Johnston JF Smith 《Canadian Metallurgical Quarterly》1997,239(2):389-401
A replicon vaccine vector system was developed from an attenuated strain of Venezuelan equine encephalitis virus (VEE). The replicon RNA consists of the cis-acting 5' and 3' ends of the VEE genome, the complete nonstructural protein gene region, and the subgenomic 26S promoter. The genes encoding the VEE structural proteins were replaced with the influenza virus hemagglutinin (HA) or the Lassa virus nucleocapsid (N) gene, and upon transfection into eukaryotic cells by electroporation, these replicon RNAs directed the efficient, high-level synthesis of the HA or N proteins. For packaging of replicon RNAs into VEE replicon particles (VRP), the VEE capsid and glycoproteins were supplied in trans by expression from helper RNA(s) coelectroporated with the replicon. A number of different helper constructs, expressing the VEE structural proteins from a single or two separate helper RNAs, were derived from attenuated VEE strains Regeneration of infectious virus was not detected when replicons were packaged using a bipartite helper system encoding the VEE capsid protein and glycoproteins on two separate RNAs. Subcutaneous immunization of BALB/c mice with VRP expressing the influenza HA or Lassa virus N gene (HA-VRP or N-VRP, respectively) induced antibody responses to the expressed protein. After two inoculations of HA-VRP, complete protection against intranasal challenge with influenza was observed. Furthermore, sequential immunization of mice with two inoculations of N-VRP prior to two inoculations of HA-VRP induced an immune response to both HA and N equivalent to immunization with either VRP construct alone. Protection against influenza challenge was unaffected by previous N-VRP immunization. Therefore, the VEE replicon system was characterized by high-level expression of heterologous genes in cultured cells, little or no regeneration of plaque-forming virus particles, the capability for sequential immunization to multiple pathogens in the same host, and induction of protective immunity against a mucosal pathogen. 相似文献
108.
GV Seledtsova VI Seledtsov DM Samarin VIa Taraban SV Sennikov EA Kashchenko VA Kozlov 《Canadian Metallurgical Quarterly》1997,124(11):550-553
The bio-psycho-social model was used in the presented study to observe the course of chronic diseases. An attempt was undertaken to correlate the psychosocial situation of 165 women with no presence of disease following breast cancer or genital cancer with their present organic status. The open discussion, a half standardized interview and the gynecological-oncological physical examination were implemented using predetermined parameters. The results of the general well-being scores from the interview and the results of organic status for all 165 patients were related using a rank-correlation between the objective and subjective score. A discrepancy between the psychosocial situation and the objective physical finding was found in the majority of women. The goal of the treatment of chronically ill patients especially following oncological tumors should thus have equal emphasis on the psychosocial and organic dimensions of the disease. 相似文献
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