A Novel Ultrafine Needle (UN) for Innocuous and Efficient Subcutaneous Insulin Delivery

Subcutaneous (SC) insulin injection has been demonstrated to be the most effective method for treatment of diabetes mellitus but is conventionally performed by hypodermic needles, leading to poor management of diabetes because of the pain, needle phobia, and tissue trauma. Identification of a viable, safe, and pain‐free alternative method has been a longstanding challenge in modern health care. Here, the thermoplastic droplet stretching technique is developed to create an ultrahigh‐aspect‐ratio needle mold with simple microstructure control. The optimized ultrafine needle (UN) with 4 mm length, minimized 120 µm outer diameter, and 15° sharp bevel angle is formed via electroplating of a metallic layer on the surface of a needle mold with forcing sharp tip. This novel UN enables minimally invasive 4 mm skin insertion to deliver insulin in the targeted SC layer. The similar relative areas under the curves of insulin concentration within UN and 31G needle in vivo insulin administration indicate that UN can ensure stable insulin absorption for secure blood glucose management. Additionally, the proposed fabrication method may facilitate industrialization and commercialization of the UN, holding great promise for replacement of hypodermic needles and for improvement of quality of life among patients with diabetes.     

A study on the accuracy of force analogy method in nonlinear static analysis

In this paper, the accuracy of the force analogy method (FAM) for nonlinear static (pushover) analysis is investigated. Hence, after explanation of the concept of FAM by a new approach, 12 2D steel special moment resisting frames with different configurations were derived from two different 3D archetypes and modeled using four various methods of capturing nonlinearity including SAP2000 super elements, OpenSees force‐based and displacement‐based fiber method, and FAM. In addition, a MATLAB code was developed for modeling and analyzing the frames by FAM. The accuracy of FAM in predictions of pushover curves, base shear forces, and plastic rotation of the critical hinges was investigated. The results indicated that in general, the predictions obtained using the FAM had a good agreement and compatibility with those from other methods of analysis currently used in practice for seismic performance assessment of structures.     

A Review on Wearable Electrospun Polymeric Piezoelectric Sensors and Energy Harvesters

In recent years, wearable sensors and energy harvesters have shown great potential for a wide range of applications in personalized healthcare, robotics, and human–machine interfaces. Among different types of materials used in wearable electronics, piezoelectric materials have gained enormous attention due to their exclusive ability to harvest energy from ambient sources. Piezoelectric materials can be utilized as sensing elements in wearable sensors while harvesting biomechanical energy. Electrospun piezoelectric polymer nanofibers are extensively investigated due to their high flexibility, ease of processing, biocompatibility, and higher piezoelectric property (in contrast to their corresponding cast films). However, as compared to piezoceramic materials, they mostly exhibit relatively lower piezoelectric coefficients. Therefore, considerable efforts have been devoted to improving the piezoelectricity of electrospun polymer nanofibers recently, resulting in significant advances. This review presents a broad overview of these advances including new material, structure designs as well as new strategies to enhance piezoelectricity of electrospun polymer nanofibers. The challenges in achieving high mechanical performance as well as high piezoelectricity are particularly discussed. The main motivation of this review is to examine these challenges and highlight effective approaches to achieving high-performance piezoelectric sensors and energy harvesters for wearable technologies.     

Where is AAR heading after the 10th International Conference?

A brief overview of research on AAR presented at the 10th AARC is given and new areas of research and future needs are highlighted. Some recent experimental data are presented as examples of details that we would need to understand in order to be able to interpret the effects of parameters such as temperature and chemical environment on the nature of the reactions occurring in the concrete, and on the results of tests carried out to determine the expansion behaviour of aggregates or concrete mixtures. Similar examples are needed for other areas and it appears that understanding AAR and its practical management need further research efforts.     

Modelling of a continuous food pressing process by dimensional analysis

This paper focuses on the development of a mathematical model of a continuous pressing operation where biscuit shape is formed. It identifies a functional relationship and predicts its parameter values using a set of observed data. Dimensional analysis was used to model biscuit thickness as a non-linear function of a number of predictor variables and multiple regression was applied for parameter estimation of the model. The results were satisfactorily tested against real data.     

Cellular design for injection moulding shop

This paper attempts to highlight the fact that application of GT does not always lead to a productive cell formation regardless of the algorithm used. The reason is that some practical issues are impossible to be included in the GT process. However a careful systematic IE analysis of the cell formed by GT may reveal new opportunities for improvements eventually leading to a more effective cell. A successful case demonstrates the idea.     

Polyethylene friction stir welding parameter optimization and temperature characterization

The use of friction stir welding (FSW) to join thermoplastics has proven to produce strong welds with good surface quality when compared to conventional welding methods. In this study, a Teflon stationary shoulder was developed to weld 3-mm-thick plates of high molecular weight polyethylene in butt-joint configuration. Different sets of welding parameters were chosen and tested to evaluate their effect on the weld strength. Also, in order to increase joint performance, the temperature generated during welding was measured. For that purpose, thermocouples were located underneath of the weld nugget surface to measure the generated frictional heat for different tool diameters and parameters. Tool diameter and rotational and welding speeds are the most influential parameters regarding the welding temperature; however, all the input parameters had statistically significant effect on the weld quality. Unlike FSW in metals, using this tool, the heat is generated mainly by surface contact of the rotating probe and copper sleeve than the base material. The strongest welded joint was able to withstand 97% of the force that is necessary to fracture the base material, without using an external heating source.     

Genetic algorithm for facilities layout problems based on slicing tree structure

The use of genetic algorithms to solve facility layout problems has gained popularity in recent years among researchers. A difficult requirement for the use of genetic algorithms in layout problems is an efficient method of coding the relevant features of a layout as a chromosome. The slicing tree structure has gained popularity in developing genetic algorithms for layout problems. However, previous implementations based on slicing tree structure mostly require repairing procedures to ensure that the chromosomes represent legal layouts after application of genetic operators. Some representations do not permit an exhaustive search. This paper reports on design, development and experimentation results of a new genetic algorithm named (GA.FLP.STS), which always produces legal chromosomes without any need for repairing procedures. A penalty system was introduced to facilitate generating facilities with acceptable dimensions. (GA.STS.FLP) required insignificant processing times even for test problems of 100 facilities solved.