土壤对架空配电线路感应雷过电压的影响研究

近年来,随着国民经济的飞速提高,人们对于电力资源的需求越来越大,电力行业随之不断发展,输配电线路逐渐遍布全国各地.当配电线路接入负荷时,通常采用传输电缆的形式接入,若此时发生雷击,雷电电磁波易通过传输电缆侵入设备,从而导致设备故障.为此,本文研究了周围土壤对架空配电线路感应雷过电压的影响.本文研究成果对后续输配电线路雷电过电压研究具有重要的理论意义.     

基于多特征融合的云平台异常点检测方法研究

针对传统云平台异常点检测方法存在准确率低和运算速度慢的问题,提出基于多特征融合的云平台异常点检测方法,构建云平台不同子系统的特征空间优化模型,实现不同子系统之间的特征自动融合.首先设计基于多特征融合的云平台异常点检测算法,对模型约束进行监测分析;然后通过试验验证方法不仅能够进行云平台异常点检测,而且比其他传统方法有更高的准确率和更快的计算速度.     

宽频测量装置两种谐波/间谐波算法比较

新能源发电大规模入网,造成电力系统电能质量问题.宽频测量装置可监测谐波/间谐波的含量,但谐波/间谐波的测量在工程实现中目前存在两种方案,有争议.介绍了这两种方案的实现方法和各自的局限性,供后续工程参考.     

基于多端口能量路由器的多能互补系统研究与测试

针对旅游旺季期间某地区负荷出现较严重的过载现象,且当地可再生能源存在功率波动较大、难以消纳的问题,依托云南省某配电网智能化改造升级示范项目,研制了一套多能(含小水电、光伏、储能)、多端口的能量路由器装置及其能量管理系统,并对基于多端口能量路由器的多能互补系统进行了研究与测试.首先对多端口能量路由器的拓扑结构和技术参数进行了介绍;其次对能量管理系统的功能进行了阐述;最后在对各端口分别进行调试后,进行全端口联合运行功能测试.测试结果表明,各端口能分别正常运行,全端口联合运行功能正常,能有效平抑直流母线电压波动,实现上层功率指令跟踪,同时在大功率运行状态下,输出波形畸变率较低,效率基本满足要求,能用于解决当地负荷过载问题,实现能量的合理配置与利用.     

配电线路不停电作业机器人研究

从传统的人工带电作业方式出发,根据国内外不停电作业机器人的发展现状,对机器人带电作业方式进行分类,并结合具体实例,描述了我国不停电作业机器人的特点,对该领域存在的问题进行分析和展望.     

Isolation and Functional Characterization of a Salt-Responsive Calmodulin-Like Gene MpCML40 from Semi-Mangrove Millettia pinnata

Salt stress is a major increasing threat to global agriculture. Pongamia (Millettia pinnata), a semi-mangrove, is a good model to study the molecular mechanism of plant adaptation to the saline environment. Calcium signaling pathways play critical roles in the model plants such as Arabidopsis in responding to salt stress, but little is known about their function in Pongamia. Here, we have isolated and characterized a salt-responsive MpCML40, a calmodulin-like (CML) gene from Pongamia. MpCML40 protein has 140 amino acids and is homologous with Arabidopsis AtCML40. MpCML40 contains four EF-hand motifs and a bipartite NLS (Nuclear Localization Signal) and localizes both at the plasma membrane and in the nucleus. MpCML40 was highly induced after salt treatment, especially in Pongamia roots. Heterologous expression of MpCML40 in yeast cells improved their salt tolerance. The 35S::MpCML40 transgenic Arabidopsis highly enhanced seed germination rate and root length under salt and osmotic stresses. The transgenic plants had a higher level of proline and a lower level of MDA (malondialdehyde) under normal and stress conditions, which suggested that heterologous expression of MpCML40 contributed to proline accumulation to improve salt tolerance and protect plants from the ROS (reactive oxygen species) destructive effects. Furthermore, we did not observe any measurable discrepancies in the development and growth between the transgenic plants and wild-type plants under normal growth conditions. Our results suggest that MpCML40 is an important positive regulator in response to salt stress and of potential application in producing salt-tolerant crops.     

Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model

Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify additional effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity.     

Usher Syndrome in the Inner Ear: Etiologies and Advances in Gene Therapy

Hearing loss is the most common sensory disorder with ~466 million people worldwide affected, representing about 5% of the population. A substantial portion of hearing loss is genetic. Hearing loss can either be non-syndromic, if hearing loss is the only clinical manifestation, or syndromic, if the hearing loss is accompanied by a collage of other clinical manifestations. Usher syndrome is a syndromic form of genetic hearing loss that is accompanied by impaired vision associated with retinitis pigmentosa and, in many cases, vestibular dysfunction. It is the most common cause of deaf-blindness. Currently cochlear implantation or hearing aids are the only treatments for Usher-related hearing loss. However, gene therapy has shown promise in treating Usher-related retinitis pigmentosa. Here we review how the etiologies of Usher-related hearing loss make it a good candidate for gene therapy and discuss how various forms of gene therapy could be applied to Usher-related hearing loss.     

The Effects of Random Porosities in Resonant Frequencies of Graphene Based on the Monte Carlo Stochastic Finite Element Model

With the distinguished properties in electronics, thermal conductivity, optical transparence and mechanics, graphene has a powerful potential in nanosensors, nano-resonators, supercapacitors, batteries, etc. The resonant frequency of graphene is an important factor in its application and working environment. However, the random dispersed porosities in graphene evidently change the lattice structure and destroy the integrity and geometrical periodicity. This paper focuses on the effects of random porosities in resonant frequencies of graphene. Monte Carlo simulation is applied to propagate the porosities in the finite element model of pristine graphene. The statistical results and probability density distribution of porous graphene with atomic vacancy defects are computed based on the Monte Carlo finite element model. The results of porous graphene with atomic vacancy defects are compared and discussed with the results of graphene with bond vacancy defects. The enhancement effects of atomic vacancy defects are confirmed in porous graphene. The influences of atomic vacancy defects on displacement and rotation vector sums of porous graphene are more concentrated in local places.     

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cells that lead to tumorigenesis are unknown. In this study, we showed that ubiquitin-specific protease 29 (USP29) stabilized Cdc25A protein expression in cancer cell lines by protecting it from ubiquitin-mediated proteasomal degradation. The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life. CRISPR-Cas9-mediated knockdown of USP29 in HeLa cells resulted in cell cycle arrest at the G0/G1 phase. We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation, migration, and invasion of cancer cells in vitro. Moreover, NSG nude mice transplanted with USP29-depleted cells significantly reduced the size of the tumors, whereas the reconstitution of Cdc25A in USP29-depleted cells significantly increased the tumor size. Altogether, our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A.