Comprehensive Analysis of hsa-miR-654-5p’s Tumor-Suppressing Functions

The pivotal roles of miRNAs in carcinogenesis, metastasis, and prognosis have been demonstrated recently in various cancers. This study intended to investigate the specific roles of hsa-miR-654-5p in lung cancer, which is, in general, rarely discussed. A series of closed-loop bioinformatic functional analyses were integrated with in vitro experimental validation to explore the overall biological functions and pan-cancer regulation pattern of miR-654-5p. We found that miR-654-5p abundance was significantly elevated in LUAD tissues and correlated with patients’ survival. A total of 275 potential targets of miR-654-5p were then identified and the miR-654-5p-RNF8 regulation axis was validated in vitro as a proof of concept. Furthermore, we revealed the tumor-suppressing roles of miR-654-5p and demonstrated that miR-654-5p inhibited the lung cancer cell epithelial-mesenchymal transition (EMT) process, cell proliferation, and migration using target-based, abundance-based, and ssGSEA-based bioinformatic methods and in vitro validation. Following the construction of a protein–protein interaction network, 11 highly interconnected hub genes were identified and a five-genes risk scoring model was developed to assess their potential prognostic ability. Our study does not only provide a basic miRNA-mRNA-phenotypes reference map for understanding the function of miR-654-5p in different cancers but also reveals the tumor-suppressing roles and prognostic values of miR-654-5p.     

Engineering the Thermoelectrical Properties of PEDOT:PSS by Alkali Metal Ion Effect

Engineering the electrical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)holds great potential for various applications such a...     

cPCN-Regulated SnO2 Composites Enables Perovskite Solar Cell with Efficiency Beyond 23％

Efficient electron transport layers(ETLs)not only play a crucial role in promoting carrier separation and electron extraction in perovskite solar cells(PSCs)but...     

Growth mechanism for zinc coatings deposited by vacuum thermal evaporation

The vacuum thermal evaporation technique was used to simultaneously deposit zinc coatings onto interstitial free steel plates and single-crystal silicon wafers ...     

凯氏定氮仪在复混肥料总氮含量测定中的运用

我国是一个农业大国。农业的发展是国民经济和社会发展的重要因素。复混肥料在农业中的运用也日益广泛。文章研究的凯氏定氮仪法的检测方法与国标方法GB/T8572-2001的原理相同。与国标法比较,总氮含量的绝对误差在0.01%～0.29%之间,极差在0.07%～0.18%之间,检测准确度和精密度都符合国家标准的要求。此方法操作简便快速高效、安全可靠,效果令人满意。     

羧酸和乙酸酐合成甲基酮的研究

酮是化学化工行业应用广泛的重要中间体,其常见的合成方法这些年来不断有新的报道。文章研究了以常见的羧酸和乙酸酐为起始原料合成甲基酮的方法。该方法实施简单,产物收率62%～89%,为酮提供了一种未见文献报道的合成新方法。     

Multistimuli‐Responsive Display Materials to Encrypt Differentiated Information in Bright and Dark Fields

Visually readable codes play a crucial role in anticounterfeiting measures. However, current coding approaches do not enable time‐dependent codes to be visually read, adjusted, and differentiated in bright and dark fields. Here, using a combined strategy of piezoelectric lattice selection, oxygen vacancy engineering, and activator doping, a lanthanide ion‐doped titanate is developed that integrates mechano‐, thermo‐, and photo‐responsive color change (>18 h for bright field), persistent luminescence (>6 h for dark field), and stimulus‐triggered multimodal luminescence. The feasibility of optical encoding, visual displaying, and stimulus‐responsive encrypting of time‐dependent, dual‐field information by using the developed material is demonstrated. In particular, the differentiated display of dual‐field modes is achieved by combining mechanostimulated abolition of only the persistent luminescence and thermo‐ and photostimulated reversal of both the color change and persistent luminescence. The results provide new insights for designing advanced materials and encryption technologies for photonic displays, information security, and intelligent anticounterfeiting.     

一种用于核辐射监测信号的多微处理系统

介绍了4兆伏静电正离子加速器的监测防护系统,该系统由多个微处理器与主控机分布式分布,组成高速多通道辐射信号采集控制系统,可以对多点核辐射的能量、强度、剂量率,剂量及剂量当量进行监测.系统的核电路部分采用最新的芯片产品,合理的硬件安排,优化的软件编程,在仅更换不同的探头后,便可探测分析γ,X及快中子辐射.在参数稍做调整之后,就可以广泛应用于类似条件的其他场所的辐射监测.     

大载荷水下滑翔器运动性能研究

在大载荷水下滑翔器的平面运动数学模型基础上,通过线性化模型初步设计了LQR控制器,建立了整体Matlab/Simulink仿真模型,研究了系统的动态性能。研究结果表明,系统在初始状态向目标状态的转化过程中,在仿真初始振荡较为剧烈,随着反馈信号的对输入信号的补偿,很快趋于稳定。仿真结果有待进一步实验验证。     

Linear Study of a Large-orbit Coaxial-waveguide Cyclotron Autoresonance Maser Amplifier

A linear theory based on Maxwell-Vlasov equations and the Laplace transform is presented to describe the large-orbit coaxial-waveguide cyclotron autoresonance maser (CARM) amplifier. A 35-GHz, TE_5,1-mode large-orbit coaxial-waveguide CARM amplifier is specifically analyzed. Good agreement between the linear theory and the nonlinear simulations is found in the exponentially growing region of the wave. Results show that the operating magnetic field and the electron-beam energy and average radius substantially affect the power, and especially, a small beam current may be unsuitable to a large-orbit CARM amplifier operation.