Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are closely related to the carcinogenic process and play a critical role in tumor metastasis. CircRNAs can lay the foundation for tumor metastasis via promoting tumor angiogenesis, make tumor cells gain the ability of migration and invasion by regulating epithelial-mesenchymal transition (EMT), interact with immune cells, cytokines, chemokines, and other non-cellular components in the tumor microenvironment, damage the normal immune function or escape the immunosuppressive network, and further promote cell survival and metastasis. Herein, based on the characteristics and biological functions of circRNA, we elaborated on the effect of circRNA via circRNA-associated competing endogenous RNA (ceRNA) network by acting as miRNA/isomiR sponges on tumor angiogenesis, cancer cell migration and invasion, and interaction with the tumor microenvironment (TME), then explored the potential interactions across different RNAs, and finally discussed the potential clinical value and application as a promising biomarker. These results provide a theoretical basis for the further application of metastasis-related circRNAs in cancer treatment. In summary, we briefly summarize the diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.     

EDGE网络的规划及资源配置研究

本文在现有网络分析的基础上,进行了EDGE数据网的规划,并通过仿真对规划结果进行了验证,最后对语音和数据网络的资源配置方法进行了研究,提出了相应的资源配置方法。     

一例典型电网运行方式调整分析

介绍了九江供电公司东部电网一条220kV电源线路停电检修方式下,单电源供电时最大限度提高供电可靠性的典型运行方式调整案例。针对九江东部电网检修方式下安全可靠性低、稳定性不足、供电压力大等安全问题进行运行方式的调整,并综合考虑了调整方式中各种技术问题,从而达到提高电网安全可靠性,利于调度员快速事故处理的目的。     

智能终端发展关键技术探讨

智能终端产品(包括手机、平板和混合式的移动计算设备)在个人和商业应用场合大量使用,终端在高速计算能力方面更新迅猛,处理能力军备竞赛将陷入硬件瓶颈,同质现象成为现实,而人机交互技术、终端应用开发环境、终端安全云服务等将成为影响智能终端向纵深人群渗透和更商业化应用领域发展的决定要素。本文旨在探讨、分析和展示上述几个关键技术的新进展和演进趋势。     

Rollback reconstruction for TDC enhanced perfusion imaging

Tomographic perfusion imaging is a significant imaging modality for stroke diagnosis.However,the low rotational speed of the C-arm(6-8 s per circle)is a chal-le...     

Repetitive Sequence Barcode Probe for Karyotype Analysis in Tripidium arundinaceum

The barcode probe is a convenient and efficient tool for molecular cytogenetics. Tripidium arundinaceum, as a polyploid wild allied genus of Saccharum, is a useful genetic resource that confers biotic and abiotic stress resistance for sugarcane breeding. Unfortunately, the basic cytogenetic information is still unclear due to the complex genome. We constructed the Cot-20 library for screening moderately and highly repetitive sequences from T. arundinaceum, and the chromosomal distribution of these repetitive sequences was explored. We used the barcode of repetitive sequence probes to distinguish the ten chromosome types of T. arundinaceum by fluorescence in situ hybridization (FISH) with Ea-0907, Ea-0098, and 45S rDNA. Furthermore, the distinction among homology chromosomes based on repetitive sequences was constructed in T. arundinaceum by the repeated FISH using the barcode probes including Ea-0663, Ea-0267, EaCent, 5S rDNA, Ea-0265, Ea-0070, and 45S rDNA. We combined these probes to distinguish 37 different chromosome types, suggesting that the repetitive sequences may have different distributions on homologous chromosomes of T. arundinaceum. In summary, this method provide a basis for the development of similar applications for cytogenetic analysis in other species.     

70%稻瘟灵可湿性粉剂的研制

制备了国内外文献未见报道的70%稻瘟灵可湿性粉剂(WP),对该剂型的配方组成、加工工艺、贮存稳定性进行了研究,并对其各项性能进行了测试,确定了优惠配方。实验结果表明,该产品的各项指标均符合可湿性粉剂标准的要求,悬浮率在90%以上,润湿时间在1min以内,在40±2℃下贮存60天后的分解率小于5%。     

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells

Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca²⁺ is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca²⁺ participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca²⁺ through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca²⁺ in both mitochondria and cytoplasm, thereby regulating cellular Ca²⁺ homeostasis. Mitochondrial Ca²⁺ transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial Ca²⁺ homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial Ca²⁺ and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial Ca²⁺ regulation helps diagnosis and therapy.