Novel configuration for three-phase hybrid power filter

A novel configuration for the power converter of a three-phase hybrid power filter is proposed in this paper. This power converter uses only a two-arm bridge structure and a DC capacitor. The hybrid power filter is configured by the proposed power converter serially connected with a passive power filter set. The salient feature of this hybrid power filter is that it permits one of the power lines of the utility connected directly to the negative terminal of the DC capacitor located in the DC side of the power converter through the passive power filter set. Consequently, the power converter uses less number of power electronic switches to reduce the manufacturing cost. A three-phase prototype is developed and tested to verify the performance of the hybrid power filter using the proposed power converter. The experimental results show that the hybrid power filter using the proposed power converter can reach the expected performance.     

Knowledge kanban system for virtual research and development

Virtual research and development (R&D) is inevitable to reduce the product life cycle. Enterprises tend to rely on their foreign partners for supporting technology and knowledge acquisition to conduct and improve firms’ product development with low R&D risk. R&D is a highly creative and knowledge-intensive activity, Therefore, efficient knowledge flow, which transmits the right knowledge to the right people at the right time, is key to improving efficiency of the R&D process.     

Isolation of TTF-1 Positive Circulating Tumor Cells for Single-Cell Sequencing by Using an Automatic Platform Based on Microfluidic Devices

Single-cell sequencing provides promising information in tumor evolution and heterogeneity. Even with the recent advances in circulating tumor cell (CTC) technologies, it remains a big challenge to precisely and effectively isolate CTCs for downstream analysis. The Cell Reveal^TM system integrates an automatic CTC enrichment and staining machine, an AI-assisted automatic CTC scanning and identification system, and an automatic cell picking machine for CTC isolation. H1975 cell line was used for the spiking test. The identification of CTCs and the isolation of target CTCs for genetic sequencing were performed from the peripheral blood of three cancer patients, including two with lung cancer and one with both lung cancer and thyroid cancer. The spiking test revealed a mean recovery rate of 81.81% even with extremely low spiking cell counts with a linear relationship between the spiked cell counts and the recovered cell counts (Y = 0.7241 × X + 19.76, R² = 0.9984). The three cancer patients had significantly higher TTF-1⁺ CTCs than healthy volunteers. All target CTCs were successfully isolated by the Cell Picker machine for a subsequent genetic analysis. Six tumor-associated mutations in four genes were detected. The present study reveals the Cell Reveal^TM platform can precisely identify and isolate target CTCs and then successfully perform single-cell sequencing by using commercially available genetic devices.