ESMRMB 2017, 34th Annual Scientific Meeting,Barcelona, ES,October 19–October 21: Abstracts,Thursday

Objective

Current magnetic resonance imaging (MRI) axon diameter measurements rely on the pulsed gradient spin-echo sequence, which is unable to provide diffusion times short enough to measure small axon diameters. This study combines the AxCaliber axon diameter fitting method with data generated from Monte Carlo simulations of oscillating gradient spin-echo sequences (OGSE) to infer micron-sized axon diameters, in order to determine the feasibility of using MRI to infer smaller axon diameters in brain tissue.

Materials and methods

Monte Carlo computer simulation data were synthesized from tissue geometries of cylinders of different diameters using a range of gradient frequencies in the cosine OGSE sequence . Data were fitted to the AxCaliber method modified to allow the new pulse sequence. Intra- and extra-axonal water were studied separately and together.

Results

The simulations revealed the extra-axonal model to be problematic. Rather than change the model, we found that restricting the range of gradient frequencies such that the measured apparent diffusion coefficient was constant over that range resulted in more accurate fitted diameters. Thus a careful selection of frequency ranges is needed for the AxCaliber method to correctly model extra-axonal water, or adaptations to the method are needed. This restriction helped reduce the necessary gradient strengths for measurements that could be performed with parameters feasible for a Bruker BG6 gradient set. For these experiments, the simulations inferred diameters as small as 0.5 μm on square-packed and randomly packed cylinders. The accuracy of the inferred diameters was found to be dependent on the signal-to-noise ratio (SNR), with smaller diameters more affected by noise, although all diameter distributions were distinguishable from one another for all SNRs tested.

Conclusion

The results of this study indicate the feasibility of using MRI with OGSE on preclinical scanners to infer small axon diameters.

     

Fitting interrelated datasets: metabolite diffusion and general lineshapes

Objective

Simultaneous modeling of true 2-D spectroscopy data, or more generally, interrelated spectral datasets has been described previously and is useful for quantitative magnetic resonance spectroscopy applications. In this study, a combined method of reference-lineshape enhanced model fitting and two-dimensional prior-knowledge fitting for the case of diffusion weighted MR spectroscopy is presented.

Materials and methods

Time-dependent field distortions determined from a water reference are applied to the spectral bases used in linear-combination modeling of interrelated spectra. This was implemented together with a simultaneous spectral and diffusion model fitting in the previously described Fitting Tool for Arrays of Interrelated Datasets (FiTAID), where prior knowledge conditions and restraints can be enforced in two dimensions.

Results

The benefit in terms of increased accuracy and precision of parameters is illustrated with examples from Monte Carlo simulations, in vitro and in vivo human brain scans for one- and two-dimensional datasets from 2-D separation, inversion recovery and diffusion-weighted spectroscopy (DWS). For DWS, it was found that acquisitions could be substantially shortened.

Conclusion

It is shown that inclusion of a measured lineshape into modeling of interrelated MR spectra is beneficial and can be combined also with simultaneous spectral and diffusion modeling.

     

Sensitive magnetic field sensor using 2D magnetic photonic crystal slab waveguide based on BIG/GGG structure

A kind of magnetic field sensor (MFS) using a two-dimensional (2D) magnetic photonic crystal (MPC) slab waveguide as the sensing structure is proposed and investigated numerically. The slab structure is based on bismuth iron garnet (BIG), a well-known magnetic material with effective magnetooptical (MO) properties, sandwiched with gadolinium gallium garnet (GGG) as substrate. The complete photonic bandgap (PBG) of the 2D MPC is simulated and optimized for realization of polarization-independent waveguides. The simulation results show that the width and position of the complete PBG depend on the thickness of the BIG slab and the radius of the air holes used in the design. By reducing the lightwave propagation losses and enhancing the mode conversion ratio, increased sensitivity is obtained. Based on the Faraday effect, a good linear relationship is observed between the normalized output light intensity and the magnetic field strength as the gyrotropy parameter g is varied from 0.13 to 0.19, a g-range used as the sensor dynamic range. The remarkable enhancement in sensing performance due to the MO effect makes the designed device suitable for magnetic field sensing. The results are discussed to provide a basis for investigation of 2D MPC slab waveguides based on the same structure, which are of particular interest for development of highly sensitive MFSs.     

考虑刚体稳定性约束条件的变形监测数据处理方法研究

在各种变形监测工程中,部分监测对象可以假设成为刚体进行处理,而刚体的稳定性始终没有被引入到变形监测数据处理中。本文旨在讨论变形监测数据处理时,如何引入刚体的稳定性,并获取整体位移信息。     

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论树生之脉设计理念在项目中的体现——记博望城一九龙半岛板块项目规划设计

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以技术集成为导向的高年级工业化住宅专题设计

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浅析伊东丰雄对于“流动性”的转变

在当下电子信息迅猛发展的时代,信息技术已经逐渐成为了人们生活当中不可或缺的一个重要部分,同时也影响着人们的生存观念和生活方式,进而对建筑的设计也产生了不小的影响和冲击。以日本建筑师伊东丰雄获得普利茨克奖为契机,在对伊东丰雄以往作品进行回顾和探讨的同时,从大家所熟悉的空间流动性为线索来解析在伊东丰雄的建筑中所包含的不同寻常的特质以及这种特质的转变。通过对建筑流动性转变的浅析,再次解读伊东在对于建筑创作的过程当中与同僚的不同之处。