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61.
NK recognition and lysis of targets are mediated by activation receptor(s) whose effects may be over-ridden by inhibitory receptors recognizing class I MHC on the target. Incubation of normal lymphoblasts with a peptide that can bind to their class I MHC renders them sensitive to lysis by syngeneic NK cells. By binding to class I MHC, the peptide alters or masks the target structure recognized by an inhibitory NK receptor(s). This target structure is most likely an "empty" dimer of class I heavy chain and beta2m as opposed to a "full" class I trimer formed by binding of specific peptide that is recognized by CTL. 相似文献
62.
SV Singh PJ Benson X Hu A Pal H Xia SK Srivastava S Awasthi HA Zaren JL Orchard YC Awasthi 《Canadian Metallurgical Quarterly》1998,128(2):197-204
A commercial patient dose verification system utilizing non-invasive metal oxide semiconductor field effect transistor (MOSFET) dosimeters originally designed for radiotherapy applications has been evaluated for use at diagnostic energy levels. The system features multiple dosimeters that may be used to monitor entrance or exit skin dose and intracavity doses in phantoms in real time. We have characterized both the standard MOSFET dosimeter designed for radiotherapy dose verification and a newly developed "high sensitivity" MOSFET dosimeter designed for lower dose measurements. The sensitivity, linearity, angular response, post-exposure response, and physical characteristics were evaluated. The average sensitivity (free in air, including backscatter) of the radiotherapy MOSFET dosimeters ranged from 3.55 x 10(4) mV per C kg(-1) (9.2 mV R(-1)) to 4.87 x 10(4) mV per C kg(-1) (12.6 mV R(-1)) depending on the energy of the x-ray field. The sensitivity of the "high sensitivity" MOSFET dosimeters ranged from 1.15 x 10(5) mV per C kg(-1) (29.7 mV R(-1)) to 1.38 x 10(5) mV per C kg(-1) (35.7 mV R(-1)) depending on the energy of the x-ray field. The high sensitivity dosimeters demonstrated excellent linearity at high energies (90 and 120 kVp) and acceptable linearity at lower energies (60 kVp). The angular response was significant for free-in-air exposures, as illustrated by the sensitivity differences between the two sides of the dosimeter, but was excellent for measurements within a tissue equivalent cylinder. The post-exposure drift response is a complicated but reproducible function of time. Real-time monitoring requires little if any corrections for the post-exposure drift response. The MOSFET dosimeter system brings some unique capabilities to diagnostic radiology dosimetry including small size, real-time capabilities, nondestructive measurement, good linearity, and a predictable angular response. 相似文献
63.
The use of combined sensors and advanced algorithms using different principles can improve rate performance over a single sensor system. Combinations of sensors and more sophisticated algorithms, however, invariably increase the complexity of pacemaker programming. An automatically optimized combined minute ventilation and activity DDDR pacemaker was developed to minimize repeated sensor adjustment. The device used subthreshold (below cardiac stimulation threshold) lead impedance to detect lead configuration at implantation automatically, followed by "implant management," including setting of lead polarity and initiation of DDDR pacing. Automatic sensor adaptation was achieved by programming a "target rate histogram" based on the patient's activity level and frequency of exertion, and the rate profile optimization process matched the recorded integrated sensor response to the target rate histogram profile. In nine patients implanted with the DX2 pacemakers, the implant management gave 100% accuracy in the detection of lead polarity. Rate profile optimization automatically increased the pacing rate during exercise between discharge and 3-month follow-up (hall walk: 78 +/- 3 vs 98 +/- 3 beats/min, and maximal treadmill exercise: 89 +/- 6 vs 115 +/- 5 beats/min, P < 0.001) with a significant increase in exercise duration during maximal exercise (7.18 +/- 1 min vs 9.56 +/- 2 min, P = 0.05). The accuracy of rate profile optimization versus manual programming was assessed at 1 month, and there was no significant difference between pacing rate kinetics and maximal pacing rate between the two methods of programming. In conclusion, pacemaker automaticity can be initiated at implantation and the self-optimized rate adaptive response appeared to be comparable to that derived from a manual programming procedure, which may reduce the need to perform time consuming sensor programming. 相似文献
64.
PK Aianot AG Aminev SV Bezborodova AV Shcherbakov SK Starov VV Drygin AA Gusev 《Canadian Metallurgical Quarterly》1998,51(2):20-24
The paper analyzes the standard legal and methodological assurance of the quality and safety of animal food raw materials and foodstuffs (meat, meat products, fish, shellfish, crayfish and their processing products) by the parasitic purity rates according the requirements under the Russian Federation's laws "On Sanitary and Epidemiological Well-Being of the Population", "On Protection of Consumer's Rights", "On Certification of Products and Services", those of SanPiN, such as 2.3.2.560-96 "Sanitary Requirements for the Quality and Safety of Food Raw Materials and Foodstuffs" and 3.2.569-96 "Prevention of Parasitic Diseases in the Russian Federation". 相似文献
65.
A more efficient and secure ID-based remote mutual authentication with key agreement scheme for mobile devices on elliptic curve cryptosystem 总被引:1,自引:0,他引:1
Recently, Yang and Chang proposed an identity-based remote login scheme using elliptic curve cryptography for the users of mobile devices. We have analyzed the security aspects of the Yang and Chang's scheme and identified some security flaws. Also two improvements of the Yang and Chang's scheme have been proposed recently, however, it has been found that the schemes have similar security flaws as in the Yang and Chang's scheme. In order to remove the security pitfalls of the Yang and Chang and the subsequent schemes, we proposed an enhanced remote user mutual authentication scheme that uses elliptic curve cryptography and identity-based cryptosystem with three-way challenge-response handshake technique. It supports flawless mutual authentication of participants, agreement of session key and the leaked key revocation capability. In addition, the proposed scheme possesses low power consumption, low computation cost and better security attributes. As a result, the proposed scheme seems to be more practical and suitable for mobile users for secure Internet banking, online shopping, online voting, etc. 相似文献
66.
BACKGROUND: A durable power of attorney for health care (DPA) allows a person to appoint a surrogate decision-maker for any future period of mental incapacity. The absence of advance directives can lead to confusion and the expenditure of resources while trying to exert a substituted judgment. METHODS: The Wisconsin DPA was presented with an organized pilot program to 150 residents who had been judged by their social workers to have the capacity to make informed decisions regarding medical care. The reasons residents gave for accepting or rejecting a DPA were analyzed. RESULTS: Seventy-nine percent prepared a DPA. Reasons for signing included allowing the resident to decide who would make medical decisions and assuring that specific wishes would be carried out. Twenty-one percent did not execute a DPA. Reasons were categorized as confusion and misunderstanding regarding the legal system, mistrust, or social isolation. CONCLUSIONS: The high rate (79%) of DPA completion is probably related to individually counseling residents. However, competent residents who despite counseling do not choose to execute a DPA can have detailed advance directives ("living wills") prepared without appointing a decision-maker. 相似文献
67.
The frequent difficulties encountered in the diagnosis of pediatric sarcomas, caused by the lack of observable differentiation at the light microscopic level, has led to the routine use of immunohistochemistry in pediatric surgical pathology. To a large degree the advent of this staining technique has led to the correct assessment of many perplexing lesions that previously would have been given inconclusive diagnoses. However, with increased usage and testing, it has become apparent that there are few, if any, "magic bullets" in immunohistochemistry for pediatric pathologists. Thus, it behooves diagnosticians to be careful in the usage of this technique, to be aware of possible discrepancies in its results, and to remember the ancillary nature of its application. The following article will review selected markers commonly used in pediatric surgical pathology, from both previous reports and the author's perspective, and will briefly consider several new phenotypic markers which have potential utility with childhood sarcomas. 相似文献
68.
R Jedeikin SK Makela AT Shennan RD Rowe G Ellis 《Canadian Metallurgical Quarterly》1982,28(2):317-322
Isoenzymes of creatine kinase (ATP:creatine phosphotransferase; EC 2.7.3.2; CK) were measured by electrophoresis in serum from cord blood and skin-puncture blood taken from 45 healthy full-term infants during the first three postnatal days. Mean total CK activities (in U/L at 30 degrees C) were 185 in cord samples, 536 in samples taken between 5--8 h postnatally, 494 between 24--33 h, and 288 in the 72-100 h samples. Values for all three isoenzymes increased to a peak over this period, with the highest values generally being found in the samples taken 5--33 h after birth; the subsequent decline was most rapid for CK-BB. Serum CK isoenzymes in cord samples and those taken at 72--100 h in the 11 babies delivered by cesarian section did not differ significantly from those of babies delivered vaginally. However the postnatal increases in total CK, CK-MM, and CK-MB (but not in CK-BB) were significantly greater in those patients born by vaginal delivery. The reasons for the increases in CK isoenzymes after birth are not clear, but our results and reported studies on the ontogeny of CK suggest that CK-MB cannot be regarded as a "cardiac-specific" isoenzyme in the neonatal period. 相似文献
69.
Xingbo Liu Ever Barbero Jing Xu Matthew Burris Keh-Minn Chang Vinod Sikka 《Metallurgical and Materials Transactions A》2005,36(8):2049-2058
Corrosion tests of 316L and two intermetallic compounds Fe3Al and FeCrSi in industrial Galvanizing (Zn-0.18Al), GALFAN (Zn-5Al), GALVALUME (Zn-55Al), and Aluminizing (Al-8Si) baths
and lab-scale static baths were conducted. In on-line tests in industrial hot-dip baths, 316L steel shows better corrosion
resistance than Fe3Al in Galvanizing, GALFAN, and GALVALUME baths. The corrosion resistance of 316L and Fe3Al is similar in Aluminizing bath. In static tests, FeCrSi shows the best corrosion resistance in pure Zn, Zn-55Al, and Al-8Si
baths. The corrosion resistance of 316L is better than that of Fe3Al. In Zn-5Al bath, 316L shows no thickness loss after the test. For the same bath composition, the corrosion rates of the
alloys in industrial baths are higher than those in static baths. Bath temperature and chemical composition play important
roles in corrosion and intermetallic layer formation. Increasing bath temperature accelerates the corrosion process and changes
the nature of intermetallic layers. A small amount of aluminum reduces the corrosion process by reducing the activity of Zn
and forming inhibition layer. However, after aluminum content reaches the critical point, the dominant corrosion process changes
from Zn-Fe reaction to Al-Fe reaction, and, consequently, the corrosion process accelerates by increasing aluminum content
in the bath. 相似文献
70.
Mohammad Sabzinejad Farash SK Hafizul Islam Mohammad S. Obaidat 《Concurrency and Computation》2015,27(17):4897-4913
Password‐based two‐party authenticated key exchange (2PAKE) protocol enables two or more entities, who only share a low‐entropy password between them, to authenticate each other and establish a high‐entropy secret session key. Recently, Zheng et al. proposed a password‐based 2PAKE protocol based on bilinear pairings and claimed that their protocol is secure against the known security attacks. However, in this paper, we indicate that the protocol of Zheng et al. is insecure against the off‐line password guessing attack, which is a serious threat to such protocols. Consequently, we show that an attacker who obtained the users' password by applying the off‐line password guessing attack can easily obtain the secret session key. In addition, the protocol of Zheng et al. does not provide the forward secrecy of the session key. As a remedy, we also improve the protocol of Zheng et al. and prove the security of our enhanced protocol in the random oracle model. The simulation result shows that the execution time of our 2PAKE protocol is less compared with other existing protocols. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献