Extracellular breakdown of collagen by mice decidual cells. A cytochemical and ultrastructural study.

The interaction of antimesometrial decidual cells and collagen fibrils was studied by light microscopy and ultrastructural cytochemistry in fed and acutely fasted mice on days 9-11 of pregnancy. Fibrillar elements in the extracellular space consisted of collagen fibrils and filamentous aggregates (disintegrating collagen fibrils). Intracellular vacuoles exhibited typical collagen immersed in electron-translucent material (clear vacuoles) and faint cross-banded collagen immersed in electron-opaque material (dark vacuoles). Fibrillar elements showed extracellular acid phosphatase activity which was stronger in the region of mature decidua than in predecidual cells region in all animals; it was conspicuous in mature decidua of fasted animals. Intracellular acid phosphatase activity was observed in dark vacuoles and lysosomes, and was absent in clear vacuoles in all cells studied. Since acid phosphatase activity reflects the presence of lysosomal hydrolases in general, the results indicate that breakdown of extracellular collagen occurs by release of lysosomal enzymes by decidual cells and also by internalization of collagen for intracellular degradation in fed and fasted mice. Collagen breakdown may be part of the process of tissue remodeling in mature and predecidual regions, however, in mature decidua, collagen breakdown is enhanced and may therefore contribute to nutrition of the fetus, specially in acutely fasted mice.     

Web用户认证信息的安全性策略

文章重点讨论用户认证信息的安全性问题,分析了常用安全认证方法及其局限性,提出了一个用户认证安全性策略,即在信息交换前,进行计算机认证,保证对话双方能够同时且不受干扰(攻击者不能改动信息)地交换信息;采用随机算法,增加算法的复杂度,降低穷举攻击的可能性。     

测井在碳酸盐岩气藏储量计算中的应用

随着测井采集技术和测井资料评价技术的飞速发展,测井技术在储量计算中的应用越来越广泛,所起的作用也越来越重要.四川测井公司经过多年的探索与实践,通过开展探井测井精细解释、RFT地层测试技术应用及测井地震结合储层横向预测技术研究,已形成了一套应用测井资料全面、细致分析地层、构造、储层的测井精细解释技术,1997～2000年间,共完成了36口井的探井精细解释工作,取得了可喜的成果,在碳酸盐岩气藏储量计算中发挥了重要作用.     

数字序列抗原的淋巴细胞的演化方法

论文对计算机免疫学中Self集的物理空间分布和识别器的构造进行了探讨性的分析,并针对传统方法识别效果差、缺乏灵活性等缺点,提出了一种基于遗传算法的具有空间自适应能力的识别器构造方法,并通过实验比较了该算法与传统识别器构造算法的效果。     

An extended discrete autoregressive model for variable bit rate video traffic encoded by scalable video codec

Designing an effective and high performance network requires accurate characterization and modeling of network traffic. This paper provides a study of the transmission, modeling, and analysis of variable bit rate (VBR) video, which is fundamental for designing protocols and for effective utilization of networks in video transmission. To meet the specified requirements of future networks, the scalable video codec (SVC) was chosen as the video compression standard. The main objective of this work was to propose a statistical model that will allow better coordination between generated SVC video traffic and original video traffic. The performance of the proposed model was evaluated by comparing the model with three existing low‐complex statistical models using graphical and statistical measurements as well as cross‐validation. For all evaluation techniques, the accuracy of the proposed model was evaluated, and the frame size distribution of the modeled traffic was found to match that of the original video traffic better than other existing models. Copyright © 2015 John Wiley & Sons, Ltd.     

准噶尔盆地莫索湾凸起八道湾组低饱和度油藏成因分析

针对准噶尔盆地莫索湾凸起八道湾组油藏前期成因研究缺乏储层物性、隔夹层对含油饱和度低的影响,从孔隙结构、储层物性及非均质隔夹层等方面开展了油藏低饱和度成因分析,剖析了构造幅度对油水分异、储层物性对油水同产区厚度、隔夹层对含油饱和度的影响。结果表明:①孔隙结构差造成储层油水分异不明显、油水置换不完全是八道湾组油藏含油饱和度低的主要原因;②储层低孔隙度与渗透率的物性特征导致油水同产厚度较大是八道湾组油藏含油饱和度低的次要原因;③由于八道湾组并没有形成区域性的、连续的隔夹层,因此,隔夹层对八道湾组油藏含油饱和度低的影响较小。研究结果将为八道湾组的高效开发提供依据,加快探勘开发进程。     

Mitochondrial DNA Together with miR-142-3p in Plasma Can Predict Unfavorable Outcomes in Patients after Acute Myocardial Infarction

Myocardial infarction is one of the leading causes of death worldwide, despite numerous efforts to find efficient prognostic biomarkers and treatment targets. In the present study, we aimed to assess the potential of six microRNAs known to be involved in cardiovascular diseases, cell-free DNA (cfDNA), and mitochondrial DNA (mtDNA) circulating in plasma to be used as prognostic tools for the occurrence of unfavorable outcomes such as major adverse cardiovascular events (MACE) after acute ST-segment elevation myocardial infarction (STEMI). Fifty STEMI patients were enrolled and monitored for 6 months for the occurrence of MACE. Plasma was collected at three time points: upon admission to hospital (T₀), at discharge from hospital (T₁), and 6 months post-STEMI (T₆). Plasma levels of miR-223-3p, miR-142-3p, miR-155-5p, miR-486-5p, miR-125a-5p, and miR-146a-5p, as well as of cfDNA and mtDNA, were measured by RT-qPCR. Results showed that the levels of all measured miRNAs, as well as of cfDNA and mtDNA, were the most increased at T₁, compared to the other two time points. In the plasma of STEMI patients with MACE compared to those without MACE, we determined increased levels of miRNAs, cfDNA, and mtDNA at T_1. Hence, we used the levels of all measured parameters at T₁ for further statistical analysis. Statistical analysis demonstrated that all six miRNAs and cfDNA plus mtDNA levels, respectively, were associated with MACE. The minimal statistical model that could predict MACE in STEMI patients was the combination of mtDNA and miR-142-3p levels, as evidenced by ROC analysis (AUC = 0.97, p < 0.001). In conclusion, the increased plasma levels of mtDNA, along with miR-142-3p, could be used to predict unfavorable outcomes in STEMI patients.     

Socially Assistive Robots in Elderly Care: A Mixed-Method Systematic Literature Review

The world’s population is aging, and developed countries are engaged in developing a new aged-care paradigm to reduce spiraling healthcare costs. Assistive technologies like Socially Assistive Robots (SAR) are being considered as enablers to support the process of care giving or keep elderly at home longer. This article reports a mixed-method systematic review of SAR in elderly care and recognizes its impact on elderly well-being, integrating evidence from qualitative and quantitative studies. It follows the principles explained in Cochrane Handbook for Systematic Reviews of Interventions and classifies interventions, measures, and outcomes of field trials of SAR in elderly care. Eighty-six studies in 37 study groups have been included. The findings imply positive effects of SAR on elderly well-being. Ten significant recommendations are made to help avoid the current limitations of existing research and to improve future research and its applicability. This review revealed that SAR can potentially enhance elderly well-being and decrease the workload on caregivers. There is a need for rigorous research methodology, person-centered care, caregiver expectation model, multimodal interaction, multimodal data collection, and modeling of culturally diverse groups to facilitate acceptability of SAR.     

Measurement of plasma etch damage by a new slow trap profilingtechnique

MOS capacitor structures with plasma damaged oxides have been used to demonstrate a new technique for profiling slow traps at the Si-SiO ₂ interface. The technique measures the density and trapping rate of slow traps by stepping the gate voltage in small increments and monitoring the resulting substrate current transients, thereby producing a profile of the traps in energy and response time. The response time is a function of the trap's energy position and distance from the interface. Some traps created by plasma etching are not obvious in quasistatic CV measurements, yet are clearly evident when the new technique is used. Results show an increase in slow trap densities and response times in the upper half of the silicon bandgap with long plasma overetch times. In comparison, wet etched control devices show only low densities of slow traps with shorter response times around the midgap     

Sensitivity of 0.1 mu m MOSFETs to manufacturing fluctuations

A sensitivity analysis of 0.1 mu m MOSFETs to manufacturing fluctuations has been carried out. The analysis reveals that the electrical parameter sensitivity in deep submicrometre devices differs from the currently produced micrometre size devices, making a revision of the validity of conventional semiconductor manufacturing heuristics for future technology mandatory.<>