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21.
22.
Christopher Wolf Sonja Smith Sjoerd J. L. van Wijk 《International journal of molecular sciences》2022,23(7)
Mutations in the Von Hippel–Lindau (VHL) gene are the driving force in many forms of clear cell renal cell carcinoma (ccRCC) and promote hypoxia-inducible factor (HIF)-dependent tumor proliferation, metastasis and angiogenesis. Despite the progress that has already been made, ccRCC generally remain resistant to conventional therapies and ccRCC patients suffer from metastasis and acquired resistance, highlighting the need for novel therapeutic options. Cysteinyl leukotriene receptor 1 (CysLTR1) antagonists, like zafirlukast, are administered in bronchial asthma to control eicosanoid signaling. Intriguingly, long-term use of zafirlukast decreases cancer risk and leukotriene receptor antagonists inhibit tumor growth, but the mechanisms still remain unexplored. Therefore, we aim to understand the mechanisms of zafirlukast-mediated cell death in ccRCC cells. We show that zafirlukast induces VHL-dependent and TNFα-independent non-apoptotic and non-necroptotic cell death in ccRCC cells. Cell death triggered by zafirlukast could be rescued with antioxidants and the PARP-1 inhibitor Olaparib, and additionally relies on HIF-2α. Finally, MG-132-mediated proteasome inhibition sensitized VHL wild-type cells to zafirlukast-induced cell death and inhibition of HIF-2α rescued zafirlukast- and MG-132-triggered cell death. Together, these results highlight the importance of VHL, HIF and proteasomal degradation in zafirlukast-induced oxidative cell death with potentially novel therapeutic implications for ccRCC. 相似文献
23.
Schnedl Wolfgang J. Schenk Michael Lackner Sonja Enko Dietmar Mangge Harald Forster Florian 《Food science and biotechnology》2019,28(6):1779-1784
Food Science and Biotechnology - Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the... 相似文献
24.
Introduction
This study investigated the modality, type and duration of contact lens wear as well as compliance and hygiene related issues (hand and case hygiene, use of tap water, dozing and overnight wear) in the UK and Germany. Questionnaires were collected anonymously from 417 UK and 767 German patients attending optometric practices for contact lens appointments. It is the seventh of a series of contact lens wearer profiles conducted since 2000.Results
The proportion of rigid gas permeable lenses worn was significantly higher at 55.4% in Germany, compared to 16.1% in the UK. Overall, a significantly larger proportion of German participants used tap water to rinse their lenses and cases (P < 0.001). Also, German respondents changed their lens cases less frequently (p < 0.001). Fewer UK than German respondents stated they washed their hands before lens insertion (p = 0.009), removal (p = 0.01), before eating (p < 0.001). German participants were less likely to wash their hands before preparing food (p = 0.042) and after using the toilet (p = 0.002). The two sample groups differed significantly regarding the care regimens they used for their CLs (p < 0.001).Conclusion
The differences between Germany and the UK highlighted in this study were caused by differences in legal regulations, plumbing and practitioners’ guidance. Although many of the questions relating to hygiene differed statistically between the two participating sample groups, the absolute differences in figures were not considered to be large. 相似文献25.
Min Xiao Jesse Thompson Jialong Shen Sonja Salmon Kunlei Liu 《American Institute of Chemical Engineers》2023,69(11):e18191
Carbonic anhydrase (CA) is an attractive biodegradable catalyst for CO2 absorption in solvent-based CO2 capture. However, maintaining the stability of CA as a homogeneous component of the solvents is a challenge. Solvent regeneration temperature typically exceeds the enzyme thermal tolerance, which leads to CA deactivation. To reduce the need for frequent CA replenishment and to avoid inactive CA accumulation in the solvent, this work shows the benefits of an immobilization strategy where CA is fixed in a second-generation design of textile structured packing (CATSP-2) modules. The enzyme-immobilized packing showed 1.5 times better performance in CO2 separation compared with traditional structured packing with a corresponding increased CO2 loading in the rich solvent. The modules exhibited good CA activity retention of ~80% during the tests without any CA replenishment. Applying CATSP-2 could potentially decrease the packing height and absorber column size for a lower cost per amount of CO2 captured. 相似文献
26.
ABSTRACT The concept of steam drying originates from the mid of the last century. However, a broad industrial acceptance of the technique has so far not taken place. The paper deals with modelling the steam drying process and applications of steam drying with in certain industrial sectors where the technique has been deemed to hove special opponunities. In the modelling scction the mass and heat transfer proceases are described along with equilibrium, capillarity and sorption phenomena occurring in porous materials during the steam drying process. In addition existing models in the literslure are presented. The applications discussed involve drying of fuels with high moisture contcna, cattle feed exemplified by sugar beet pulp. lumber. paper pulp. paper and sludges. Steam drying is compared to flue gas drying of biofuels prior to combustion in a boiler. With reference to a current insrallation in Sweden. the exergy losses. as manifested by loss of co-generation cupacity. are discussed. The energy saving potentid when using steam drying of sugar beet pulp as compared to other possible plant configurations is demonstrated. Mechanical vapour recompression applied to steam drying is analysed with reference to reponed dau from industriul plsnts. Finally. environmcntul advantages when using steam drying are presented. 相似文献
27.
Sonja Berg Melanie J. Leng Christopher P. Kendrick Holger Cremer Bernd Wagner 《SILICON》2013,5(1):19-34
Organic carbon occluded in diatom silica is assumed to be protected from degradation in the sediment. δ13C from diatom carbon (δ13C(diatom)) therefore potentially provides a signal of conditions during diatom growth. However, there have been few studies based on δ13C(diatom). Numerous variables can influence δ13C of organic matter in the marine environment (e.g., salinity, light, nutrient and CO2 availability). Here we compare δ13C(diatom) and δ13C(TOC) from three sediment records from individual marine inlets (Rauer Group, East Antarctica) to (i) investigate deviations between δ13C(diatom) and δ13C(TOC), to (ii) identify biological and environmental controls on δ13C(diatom) and δ13C(TOC), and to (iii) discuss δ13C(diatom) as a proxy for environmental and climate reconstructions. The records show individual δ13C(diatom) and δ13C(TOC) characteristics, which indicates that δ13C is not primarily controlled by regional climate or atmospheric CO2 concentration. Since the inlets vary in water depths offsets in δ13C are probably related to differences in water column stratification and mixing, which influences redistribution of nutrients and carbon within each inlet. In our dataset changes in δ13C(diatom) and δ13C(TOC) could not unequivocally be ascribed to changes in diatom species composition, either because the variation in δ13C(diatom) between the observed species is too small or because other environmental controls are more dominant. Records from the Southern Ocean show depleted δ13C(diatom) values (1–4 ‰) during glacial times compared to the Holocene. Although climate variability throughout the Holocene is low compared to glacial/interglacial variability, we find variability in δ13C(diatom), which is in the same order of magnitude. δ13C of organic matter produced in the costal marine environment seems to be much more sensitive to environmental changes than open ocean sites and δ13C is of strongly local nature. 相似文献
28.
Min Guo Sonja Gamby Yue Zheng Herman O. Sintim 《International journal of molecular sciences》2013,14(9):17694-17728
Bacteria respond to different small molecules that are produced by other neighboring bacteria. These molecules, called autoinducers, are classified as intraspecies (i.e., molecules produced and perceived by the same bacterial species) or interspecies (molecules that are produced and sensed between different bacterial species). AI-2 has been proposed as an interspecies autoinducer and has been shown to regulate different bacterial physiology as well as affect virulence factor production and biofilm formation in some bacteria, including bacteria of clinical relevance. Several groups have embarked on the development of small molecules that could be used to perturb AI-2 signaling in bacteria, with the ultimate goal that these molecules could be used to inhibit bacterial virulence and biofilm formation. Additionally, these molecules have the potential to be used in synthetic biology applications whereby these small molecules are used as inputs to switch on and off AI-2 receptors. In this review, we highlight the state-of-the-art in the development of small molecules that perturb AI-2 signaling in bacteria and offer our perspective on the future development and applications of these classes of molecules. 相似文献
29.
Relevance of the acid–base approach in prediction of adhesion properties in two‐component injection moulding 下载免费PDF全文
Eduard Kraus Sonja Horvat Christian Deubel Christian Staudigel Benjamin Baudrit Peter Heidemeyer Martin Bastian Irina Starostina Oleg Stoyanov 《应用聚合物科学杂志》2016,133(8)
We demonstrate the use of innovative wetting method in prediction of the adhesion properties of biobased polymers for two‐component injection moulding, taking into account the acid–base surface properties of joined materials. The measurements were carried out in accordance with modified Berger method by calculation of the difference in shortened acidity parameter ΔDshort between hard and soft component. Correlation factors up to 0.99 were observed between ΔDshort and peel force. In comparison to results obtained by conventional wetting methods, high potential for the selection of components with high interface adhesion and for prediction of the functionality by the acid–base approach was demonstrated. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43048. 相似文献
30.
Sonja Haastrup Donghong Yu Thomas Broch Kim Lambertsen Larsen 《Color research and application》2016,41(5):484-492
The properties of polypropylene (PP) mixed with masterbatch (MB) and liquid color concentrates (LCC), respectively, were compared by preparing samples of PP with MB and PP with LCC and neat PP as a reference material using 1–4 extrusion cycles. Two colors were examined, i.e., a white color consisting of pigment white 6, and a green color consisting of pigment white 6, pigment blue 15:3, and pigment green 7. The color difference between PP prepared with MB and LCC was determined and the mechanical, rheological, and crystalline properties of PP prepared with MB and LCC were found to be generic. The color of PP obtained from MB and LCC were comparable. Further, it was found that the tensile strength, the viscosity, and the crystal structure obtained were similar when using LCC instead of MB. The viscosity of the treated PP generally decreased with increasing extruder retention time due to thermal degradation. The tensile strength and the crystal structure were independent of increased extruder retention time. © 2015 Wiley Periodicals, Inc. Col Res Appl, 41, 484–492, 2016 相似文献