Bile secretion in dogs after intravenous administration of glucose

The effect of drop infusions of 10% glucose solution for parenteral nutrition, in a dose of 2 g/kg, on bile secretion was studied in experiments on dogs with chronic gallbladder-duodenal fistulas. It was demonstrated that the infusion of hypertonic glucose solution inhibits bile production quantitatively and qualitatively.     

Irradiation dose for personnel during brachytherapy of malignant neoplasms with 32P microsources

Experimental measurements of the local absorbed radiation dose in the most irradiated parts of the bodies of personnel (the skin of the hands and palms, eyes, thorax, and abdomen of operators) by means of high sensitivity TLD-500K thermoluminescence detectors are reported. It is found that, for ³²P microsources with a total activity of 100 MBq, after 6 hours of work without protective x-ray gloves during a simulation of placing a real preparation in the region of the liver of an adult phantom, the maximum local irradiation dose to the hands (the skin of the left middle finger and thumb) from bremsstrahlung with deduction of the natural background and without special protective measures is 0.54 ± 0.001 mGy, the minimum dose (skin on the palm of the right hand) is 0.1 ± 0.01 mGy, and the irradiation of the thorax, abdomen, and eyes of the operator is less than 0.12 mGy. This presents no radiation hazard, even for repeated work with these sources. Translated from Atomnaya énergiya, Vol. 105, No. 4, pp. 233–235, October, 2008.     

Mixed effect modeling of sumatriptan pharmacokinetics during drug development. I: Interspecies allometric scaling

A sample of 22 subjects was studied from a population of adults who had suffered from bacterial meningitis in childhood. Audiovestibular, oculomotor and neuropsychological investigations were performed and quality of life was assessed. An age-matched control group of 20 subjects was recruited. In the meningitis group, nine subjects had abnormal pure tone audiograms. One was previously undiagnosed and a progression was found in four. There was an overrepresentation of subclinical vestibular pathology (6 out of 9 (67%)) in this group. Audiovestibular test results showed a peripheral pattern and oculomotor tests were normal. The quality of life scores of those with hearing loss were significantly higher than those in the control group. Neuropsychological tests of brain dysfunction were abnormal in six out of 22 (27%) who had recovered from meningitis. The prevalence of such dysfunctions was not related to audiovestibular disorder. The quality of life scores of those with brain dysfunctions were similar to those of the control group. The findings of reduced auditory memory and tone level perception in four out of 22 (18%), suggest that lesions of central auditory pathways may follow from bacterial meningitis. The results support the idea that inner ear damage is the major cause of hearing loss after bacterial meningitis. Despite the absence of brainstem involvement, central nervous system lesions with disturbed auditory processing and language functions can be of significance. The high frequency of discrete brain dysfunctions indicate that a thorough neuropsychological investigation is required after bacterial meningitis.     

Photophysical properties of indolo[3,2-b]carbazoles as a promising class of optoelectronic materials

The photophysical properties of new synthesized indolocarbazoles, i.e., indolo[3,2-b]carbazole and its derivatives, have been comparatively analyzed. It is shown that their photosensitivity (total photosensitivity to (5–8) × 10⁻² (lx s)⁻¹, spectral photosensitivity ∼10⁵ cm² J⁻¹, and free carrier photogeneration quantum yield of 0.1) and transport (effective mobility in 5,11-dioctyl indolo[3,2-b]carbazole is more than 10⁻⁵ cm²/(V s)) parameters significantly exceed those of pentacene, which, among molecular media (organic crystals), exhibits the highest carrier photogeneration quantum yields. The high photoluminescence intensity of synthesized indolo[3,2-b]carbazole derivatives shows promise for their applicability in electroluminescent devices.     

Dimensional effect in percolation processes

Conclusions Analysis of the geometrical special features of the sintered granular systems with large differences in the particle size of the components makes it possible to explain, to a first approximation, the experimentally detected dimensional effects of resistance variations.The proposed method of analytical evaluation of the variation of resistance can be used for predicting the nature and scale of the expected effects in a wide range of the variation of the determining parameters with the accuracy ± (20–25)% which is comparable with the scatter of the experimental data caused by fluctuations of the determining parameters in processing (by the particle size of the conductor and the insulator, residual porosity, the properties of the initial components and percolation parameters x_c, t).Translated from Poroshkovaya Metallurgiya, No. 7(283), pp. 64–71, July, 1986.