Distribution of Etoposide-Loaded Hydrophilic Albumin Microspheres in Mice

Hydrophilic albumin microspheres of etoposide were prepared by the emulsion polymerization technique using glutaraldehyde as the cross-linking agent. The microspheres prepared had a mean diameter of 1.5 μm. The microspheres were injected into mice by the intravenous route. In all, 12 mice were selected for the study, out of which 10 were given the drug-loaded microspheres and 2 were kept as solvent control. The mice were sacrificed after 24 hr and the accumulation of drug was determined in lungs, liver, and kidney.     

Selection of optimized features for fusion of palm print and finger knuckle‐based person authentication

The impact of digital technology in biometrics is much more efficient at interpreting data than humans, which results in completely replacement of manual identification procedures in forensic science. Because the single modality‐based biometric frameworks limit performance in terms of accuracy and anti‐spoofing capabilities due to the presence of low quality data, therefore, information fusion of more than one biometric characteristic in pursuit of high recognition results can be beneficial. In this article, we present a multimodal biometric system based on information fusion of palm print and finger knuckle traits, which are least associated to any criminal investigation as evidence yet. The proposed multimodal biometric system might be useful to identify the suspects in case of physical beating or kidnapping and establish supportive scientific evidences, when no fingerprint or face information is present in photographs. The first step in our work is data preprocessing, in which region of interest of palm and finger knuckle images have been extracted. To minimize nonuniform illumination effects, we first normalize the detected circular palm or finger knuckle and then apply line ordinal pattern (LOP)‐based encoding scheme for texture enrichment. The nondecimated quaternion wavelet provides denser feature representation at multiple scales and orientations when extracted over proposed LOP encoding and increases the discrimination power of line and ridge features. To best of our knowledge, this first attempt is a combination of backtracking search algorithm and 2D²LDA has been employed to select the dominant palm and knuckle features for classification. The classifiers output for two modalities are combined at unsupervised rank level fusion rule through Borda count method, which shows an increase in performance in terms of recognition and verification, that is, 100% (correct recognition rate), 0.26% (equal error rate), 3.52 (discriminative index), and 1,262 m (speed).     

Favorable influence of ssDNA-functionalized SWCNT on the navigation pattern of C. elegans

Microsystem Technologies - Single-Walled Carbon Nanotubes (SWCNTs) are widely used as potential carriers in drug delivery systems. The objective of this work was to observe the effects of pristine,...     

Retraction of “Developing an integrated display of health data for aging in place”

The following article from Human Factors and Ergonomics in Manufacturing & Service Industries, “Developing an Integrated Display of Health Data for Aging in Place,” by Yang Gong and Arpita Chandra, published online on October 20, 2011 in Wiley Online Library ( www.onlinelibrary.wiley.com ), has been retracted by agreement between the authors, the journal Editors‐in‐Chief, Waldemar Karwowski and Gavriel Salvendy, and Publisher Wiley Periodicals, Inc. The retraction has been agreed as these articles were mistakenly published after being rejected.     

I-convergence in probabilistic n-normed space

In this article we introduce the notion of I-Cauchy sequence and I-convergent sequence in probabilistic n-normed space. The concept of I*-Cauchy sequence and I*-convergence in probabilistic n-normed space are also introduced and some of their properties related to these notions have been established.     

Crack growth in transforming ceramics under cyclic tensile loads

The mechanisms of stable growth of short fatigue cracks (crack length up to 1 mm) at room temperature in magnesia-partially stabilized zirconia subjected to cyclic tensile loads were investigated. Single edge-notched specimens were fractured in the four-point bend configuration under cyclic and quasi-static tensile loads. At a load ratio of 0.1, the threshold stress intensity factor range, K, for fracture initiation in cyclic tension is as low as 3.4 M Pam^1/2, and catastrophic failure occurs at K=6.6 M Pam^1/2. For crack length less than 1 mm and for plane strain conditions, growth rates are highly discontinuous, and periodic crack arrest is observed after growth over distances of the order of tens of micrometres. Crack advance could only be resumed with an increase in the far-field stress intensity range. The mechanisms of short crack advance in cyclic tension are similar to those observed under quasi-static loads, and the tensile fatigue effect appears to be a manifestation of static failure modes. A model is presented to provide an overall framework for the tensile fatigue crack growth characteristics of partially stabilized zirconia. Experimental results are also described to demonstrate the possibility of stable room temperature crack growth under cyclic tension in fine-grained tetragonal zirconia polycrystals, partially stabilized with Y₂O₃. The growth of cracks in transformation-toughened ceramics is found to be strongly influenced by the crack size and shape, stress state and specimen geometry.     

Radiation-induced modification of polyurethane with hydroxyethyl methacrylate: blood compatibility

An attempt is made to develop the hydrophilic grafting of polyether urethane urea with hydroxyethyl methacrylate (hema) using⁶⁰Coγ-irradiation for achieving optimum hydrophilic/hydrophobic property needed towards blood compatibility. Contact angle method and platelet adhesion from calf’s blood are used to determine the suitability of these modified surfaces.     

Photographing impact of molten molybdenum particles in a plasma spray

Plasma-sprayed molten molybdenum particles (∼40 μm in diameter) were photographed impinging at high velocity (∼140 m/s) on a glass substrate at room temperature. An optical sensor detected thermal radiation emitted by a droplet as it approached the substrate and activated a time delay unit. After a selected time interval, an Nd:YAG laser was triggered, emitting a 5 ns pulse that provided illumination for a charge-coupled device (CCD) camera to photograph the impacting droplet through a long-range microscope. By varying the delay before pulsing the laser, different stages of droplet deformation were recorded. Impacting droplets spread into a thin circular film that ruptured and broke into small fragments. An optical detector recording thermal radiation from the impacting droplet gave a signal that increased as the droplet spread out, reached a maximum when the liquid film began to rupture, and decreased as portions of the droplet recoiled because of surface tension and then flew out of view of the photodetector.     

Structural Studies of TeO2–SeO2–Na2O Glass System

Glass Physics and Chemistry - The growth of nanocrystalization in TeO2–SeO2–Na2O glasses is achieved by the conventional heat treatment method. The influence of Na2O concentration on...     

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cells that lead to tumorigenesis are unknown. In this study, we showed that ubiquitin-specific protease 29 (USP29) stabilized Cdc25A protein expression in cancer cell lines by protecting it from ubiquitin-mediated proteasomal degradation. The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life. CRISPR-Cas9-mediated knockdown of USP29 in HeLa cells resulted in cell cycle arrest at the G0/G1 phase. We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation, migration, and invasion of cancer cells in vitro. Moreover, NSG nude mice transplanted with USP29-depleted cells significantly reduced the size of the tumors, whereas the reconstitution of Cdc25A in USP29-depleted cells significantly increased the tumor size. Altogether, our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A.