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51.
Rabia Rasool Inam Ullah Bismillah Mubeen Sultan Alshehri Syed Sarim Imam Mohammed M. Ghoneim Sami I. Alzarea Fahad A. Al-Abbasi Bibi Nazia Murtaza Imran Kazmi Muhammad Shahid Nadeem 《International journal of molecular sciences》2022,23(3)
Breast cancer is a diverse disease caused by mutations in multiple genes accompanying epigenetic aberrations of hazardous genes and protein pathways, which distress tumor-suppressor genes and the expression of oncogenes. Alteration in any of the several physiological mechanisms such as cell cycle checkpoints, DNA repair machinery, mitotic checkpoints, and telomere maintenance results in genomic instability. Theranostic has the potential to foretell and estimate therapy response, contributing a valuable opportunity to modify the ongoing treatments and has developed new treatment strategies in a personalized manner. “Omics” technologies play a key role while studying genomic instability in breast cancer, and broadly include various aspects of proteomics, genomics, metabolomics, and tumor grading. Certain computational techniques have been designed to facilitate the early diagnosis of cancer and predict disease-specific therapies, which can produce many effective results. Several diverse tools are used to investigate genomic instability and underlying mechanisms. The current review aimed to explore the genomic landscape, tumor heterogeneity, and possible mechanisms of genomic instability involved in initiating breast cancer. We also discuss the implications of computational biology regarding mutational and pathway analyses, identification of prognostic markers, and the development of strategies for precision medicine. We also review different technologies required for the investigation of genomic instability in breast cancer cells, including recent therapeutic and preventive advances in breast cancer. 相似文献
52.
Syed Safdar Ali Khalid Mohammed Khan Hartmut Echner Wolfgang Voelter Mashooda Hasan Atta-ur-Rahman 《Advanced Synthesis \u0026amp; Catalysis》1995,337(1):12-17
Two new synthons, Fmoc-L-Arg(biphenyl-4-sulphonyl)-OH ( 8 ) and Fmoc-Arg(4-methoxy-3-t-butylbenzenesulphonyl)-OH ( 14 ), are prepared for the synthesis of arginine-containing peptides. These groups are cleaved by commonly employed trifluoroacetic acid and methanesulphonic acid. Kinetic studies reveal that extended bicyclic aromatic conjugation, as in biphenyl, slightly improves the acid lability compared to the electron-donating t-butyl group. 相似文献
53.
54.
Sobia Noreen Sara Hasan Shazia Akram Ghumman Syed Nasir Abbas Bukhari Bushra Ijaz Huma Hameed Huma Iqbal Afeefa Aslam Mervat Abdelaziz Mohamed Elsherif Shazia Noureen Hasan Ejaz 《International journal of molecular sciences》2022,23(5)
The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characterize polysaccharide nanoparticles for methotrexate (MTX) delivery. The nanoparticles (NPs) were prepared by Abelmoschus esculentus mucilage (AEM) and chitosan (CS) by the modified coacervation method, followed by ultra-sonification. The NPs showed much better pharmaceutical properties with a spherical shape and smooth surface of 213.4–254.2 nm with PDI ranging between 0.279–0.485 size with entrapment efficiency varying from 42.08 ± 1.2 to 72.23 ± 2.0. The results revealed NPs to possess positive zeta potential and a low polydispersity index (PDI). The in-vitro drug release showed a sustained release of the drug up to 32 h with pH-dependence. Blank AEM -CS NPs showed no in-vivo toxicity for a time duration of 14 days, accompanied by high cytotoxic effects of optimized MTX loaded NPs against MCF-7 and MD-MBA231 cells by MTT assay. In conclusion, the findings advocated the therapeutic potential of AEM/CS NPs as an efficacious tool, offering a new perspective for pH-responsive routing of anticancer drugs with tumor cells as a target. 相似文献
55.
Out of the many promising applications of metal hydrides, refrigeration, heat pumping and heat transformation are important. In order to achieve improved performance, a novel three-alloy cycle is proposed in which, for heat input at an intermediate temperature, heat outputs at high temperature and also at warm temperature are obtained in addition to refrigeration. The performance of this cycle using the alloys LaNi4.6Sn0.4, LaNi4.7Al0.3 and MmNi4.5Al0.5 is studied based on thermodynamics and reaction kinetics. Coefficients of performance, half-cycle times and specific alloy outputs are evaluated. 相似文献
56.
Gold(Au)thin films were deposited on SiO2 substrate under argon(Ar)gas environment using RF(radio frequency)magnetron sputtering at room temperature for various... 相似文献
57.
Adi Md Sikin Markus Walkling-Ribeiro Syed S. H. Rizvi 《Food and Bioprocess Technology》2017,10(12):2132-2145
Individual and combined effects of high pressure nitrous oxide (HPN2O), heat, and antimicrobials on the inactivation of Escherichia coli, Listeria innocua, and Bacillus atrophaeus endospores in milk were all evaluated after 20-min treatments. Stand-alone milk treatments with HPN2O (15.2 MPa), heat (45 and 65 °C), or nisin (50 and 150 IU mL?1) resulted in log10 reductions ranging only from 0.1 to 2.1 for E. coli and L. innocua. Combining HPN2O (15.2 MPa) with heat (65 °C) inactivated 6.0 and 5.1 log10 in the vegetative bacteria, respectively. Similarly, reductions of 5.9 and ≥ 6.0 log10 of respective E. coli and L. innocua cells in milk were achieved through a combination of HPN2O (15.2 MPa), heat (65 °C), and nisin (150 IU mL?1). A 2.5 log10 cycle inactivation of spores was obtained by HPN2O, nisin (at both 50 and 150 IU mL?1), and lysozyme (50 μg mL?1) at 85 °C. Combining these processing techniques resulted in significantly greater microbial inactivation (p < 0.05) than the sum of individual reductions from each treatment alone, indicating synergistic effects. HPN2O irrespective of processing temperatures did not cause any occurrence of sub-lethally injured cells or disruption in colloidal stability of milk at 65 and 85 °C (p ≥ 0.05). Color and pH changes in milk following the most demanding treatment conditions were minimal. 相似文献
58.
59.
Syed Jawad Ali Shah Haiyang Zhong Qianqian Zhang Huanxiang Liu 《International journal of molecular sciences》2022,23(5)
The formation of neurofibrillary tangles (NFT) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein Tau is a hallmark of tauopathies, including Alzheimer’s Disease. It has been reported that acetylation, especially K174 located in the proline-rich region, can largely promote Tau aggregation. So far, the mechanism of the abnormal acetylation of Tau that affects its misfolding and aggregation is still unclear. Therefore, revealing the effect of acetylation on Tau aggregation could help elucidate the pathogenic mechanism of tauopathies. In this study, molecular dynamics simulation combined with multiple computational analytical methods were performed to reveal the effect of K174 acetylation on the spontaneous aggregation of Tau peptide 171IPAKTPPAPK180, and the dimerization mechanism as an early stage of the spontaneous aggregation was further specifically analyzed by Markov state model (MSM) analysis. The results showed that both the actual acetylation and the mutation mimicking the acetylated state at K174 induced the aggregation of the studied Tau fragment; however, the effect of actual acetylation on the aggregation was more pronounced. In addition, acetylated K174 plays a major contributing role in forming and stabilizing the antiparallel β-sheet dimer by forming several hydrogen bonds and side chain van der Waals interactions with residues I171, P172, A173 and T175 of the corresponding chain. In brief, this study uncovered the underlying mechanism of Tau peptide aggregation in response to the lysine K174 acetylation, which can deepen our understanding on the pathogenesis of tauopathies. 相似文献
60.
Hindatu Yusuf Syed Mohammad Daniel Syed Mohamed Ramesh Subramaniam 《Chemical Engineering Communications》2019,206(6):731-745
Medium-chain-length poly-3-hydroxyalkanoates (PHA) and carboxyl group-functionalized multiwalled carbon nanotubes (MC) were used to fabricate a composite membrane for application in a double-chambered microbial fuel cell (MFC). MC was composited into PHA at 5%, 10%, and 20% w/w via ultrasound dispersion blending method. PHA-MC composite was compared with Nafion 117 as proton exchange membrane in MFC operated with palm oil mill effluent (POME) wastewater. The composite exhibited prerequisite separator membrane characteristics. The dispersion of MC in the polymer matrix increased its interfacial surface area and water uptake properties. PHA-MC10% membrane in MFC showed maximum power density of 361?mW/m2, which was comparable with Nafion 117 (372?mW/m2). Internal resistance decrease, chemical oxygen demand (COD) removal, coulombic efficiency (CE), and conductivity of the PHA-MC10% were superior to Nafion 117. The environmental-friendly material could provide an alternative towards realizing practical MFC application. 相似文献