全文获取类型
收费全文 | 1364篇 |
免费 | 7篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 10篇 |
化学工业 | 65篇 |
金属工艺 | 19篇 |
机械仪表 | 11篇 |
建筑科学 | 9篇 |
能源动力 | 14篇 |
轻工业 | 45篇 |
无线电 | 35篇 |
一般工业技术 | 162篇 |
冶金工业 | 892篇 |
原子能技术 | 4篇 |
自动化技术 | 106篇 |
出版年
2022年 | 5篇 |
2021年 | 5篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 9篇 |
2016年 | 10篇 |
2015年 | 3篇 |
2014年 | 14篇 |
2013年 | 22篇 |
2012年 | 19篇 |
2011年 | 7篇 |
2010年 | 10篇 |
2009年 | 14篇 |
2008年 | 14篇 |
2007年 | 24篇 |
2006年 | 13篇 |
2005年 | 21篇 |
2004年 | 20篇 |
2003年 | 18篇 |
2002年 | 8篇 |
2001年 | 11篇 |
2000年 | 11篇 |
1999年 | 31篇 |
1998年 | 297篇 |
1997年 | 159篇 |
1996年 | 113篇 |
1995年 | 65篇 |
1994年 | 56篇 |
1993年 | 56篇 |
1992年 | 12篇 |
1991年 | 24篇 |
1990年 | 10篇 |
1989年 | 18篇 |
1988年 | 18篇 |
1987年 | 18篇 |
1986年 | 25篇 |
1985年 | 24篇 |
1984年 | 7篇 |
1983年 | 13篇 |
1982年 | 11篇 |
1981年 | 8篇 |
1980年 | 15篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 25篇 |
1976年 | 60篇 |
1975年 | 7篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1971年 | 6篇 |
排序方式: 共有1372条查询结果,搜索用时 730 毫秒
51.
Sajid Husain G. S. R. Sastry N. Prasada Raju 《Journal of the American Oil Chemists' Society》1991,68(11):822-826
A simple method for quality assessment of heated oils and fats is described. The proposed method involves precise determination
of molecular weight averages (MWA)viz., the weight average molecular weight (
), the number average molecular weight (
) and the Z-average molecular weight (
) by high performance size exclusion chromatography (HPSEC) and their quantitative correlation to percent polar material obtained
by column chromatography (CC). Change in MWA on heat treatment of fourteen different edible oils and fats at 180° ± 2°C for
eight 8-hr days is studied. Relative standard deviations and regression coefficients of correlation between MWA and their
ratios (
, {
}, {
}, {
}, {
} and {
)vs percent polar material have been reported. Probable discard time was predicted for all the oils based on the above-mentioned
correlations and also from the percent of high molecular weight (H. Mwt) species formed. It was observed that the oils which
are generally recommended for coronary patients deteriorated faster. A possibility of extending this methodology to the frying
oils is suggested.
Part of the work was presented at “40th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy” at Georgia
World Congress Centre, USA, 1989.
IICT Communication No. 2630. 相似文献
52.
The controlled assembly of nanoparticles in thin film form on solid supports, both as monolayers and as superlattice structures, is a problem of considerable topical interest. Among the many interactions used to program the assembly of nanoparticles, electrostatic forces are particularly interesting for many reasons. This Account deals with assembling surface-modified nanoparticles in thin film form using electrostatic interactions at the air-water interface and in thermally evaporated lipid films. The generality of the electrostatic assembly protocol is demonstrated in the immobilization of DNA and proteins in lipid films. 相似文献
53.
Aubin J.-P. Lygeros J. Quincampoix M. Sastry S. Seube N. 《Automatic Control, IEEE Transactions on》2002,47(1):2-20
Impulse differential inclusions are introduced as a framework for modeling hybrid phenomena. Connections to standard problems in the area of hybrid systems are discussed. Conditions are derived that allow one to determine whether a set of states is viable or invariant under the action of an impulse differential inclusion. For sets that violate these conditions, methods are developed for approximating their viability and invariance kernels, that is the largest subset that is viable or invariant under the action of the impulse differential inclusion. The results are demonstrated on examples 相似文献
54.
Tripathi RM Mahapatra S Raghunath R Sastry VN Krishnamoorthy TM 《The Science of the total environment》2000,250(1-3):43-50
The daily intake of manganese (Mn) estimated through air, water and duplicate dietary analysis is found to range from 0.67 to 4.99 mg with a mean value of 2.21 mg. Ingestion through food contributed to the predominant fraction of the intake. The turnover rate of Mn through blood is approximately 2 h, based on the mean concentration of Mn in blood of 1.54 microg l(-1). The average concentrations of Mn in water and air were approximately 1.42 microg l(-1) and 37 ng m(-3), respectively. The daily intake of Mn by the adult population of Mumbai is closer to the lower bound of the recommended limit of 2-5 mg. Electro Thermal Atomic Absorption Spectrophotometry (ET-AAS), has been used for the determination of Mn in a variety of environmental and human biological fluids. The detection limit of Mn for a volume injection of 20 microl is 2 pg absolute. The precision of the method is established by analyzing a synthetic mixture containing various elements in different quantities (0.5-10 ppm) and is found to be within +/- 8%. The reliability of estimation is further assessed through the analysis of Standard Reference Materials (SRMs) of soil, hay, milk powder and fish tissue obtained from IAEA. 相似文献
55.
Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney
TP Dousa 《Canadian Metallurgical Quarterly》1999,55(1):29-62
Investigations of recent years revealed that isozymes of cyclic-3', 5'-nucleotide phosphodiesterase (PDE) are a critically important component of the cyclic-3',5'-adenosine monophosphate (cAMP) protein kinase A (PKA) signaling pathway. The superfamily of cyclic-3', 5'-phosphodiesterase (PDE) isozymes consists of at least nine gene families (types): PDE1 to PDE9. Some PDE families are very diverse and consist of several subtypes and numerous PDE isoform-splice variants. PDE isozymes differ in molecular structure, catalytic properties, intracellular regulation and location, and sensitivity to selective inhibitors, as well as differential expression in various cell types. A number of type-specific "second-generation" PDE inhibitors have been developed. Current evidence indicates that PDE isozymes play a role in several pathobiologic processes in kidney cells. In rat mesangial cells, PDE3 and PDE4 compartmentalize cAMP signaling to the PDE3-linked cAMP-PKA pathway that modulates mitogenesis and PDE4-linked cAMP-PKA pathway that modulates generation of reactive oxygen species. Administration of selective PDE isozyme inhibitors in vivo suppresses proteinuria and pathologic changes in experimental anti-Thy-1.1 mesangial proliferative glomerulonephritis in rats. Increased activity of PDE5 (and perhaps also PDE9) in glomeruli and in cells of collecting ducts in sodium-retaining states, such as nephrotic syndrome, accounts for renal resistance to atriopeptin; diminished ability to excrete sodium can be corrected by administration of the selective PDE5 inhibitor zaprinast. Anomalously high PDE4 activity in collecting ducts is a basis of unresponsiveness to vasopressin in mice with hereditary nephrogenic diabetes insipidus. Apparently, PDE isozymes apparently also play an important role in the pathogenesis of acute renal failure of different origins. Administration of PDE isozyme-selective inhibitors suppresses some components of immune responses to allograft transplant and improves preservation and survival of transplanted organ. PDE isozymes are a target for action of numerous novel selective PDE inhibitors, which are key components in the design of novel "signal transduction" pharmacotherapies of kidney diseases. 相似文献
56.
57.
RG Grabitz F Freudenthal M Sigler TP Le C Boosfeld S Handt G von Bernuth 《Canadian Metallurgical Quarterly》1998,31(3):677-683
Glyceraldehyde-3-phosphate dehydrogenase (G3PDH) is often used as a control gene for mRNA expression, however it has been proposed to be overexpressed in all hepatocellular carcinomas (HCC). Equal amounts of tumor and paired normal (T/N) RNA, based on OD260/280 nm, were compared using ethidium bromide staining, poly-T probing, gene-specific dot blot and Northern blots using control probes G3PDH, actin and histone H4. Using mRNA blots 13/20 surgical HCC pairs did not overexpress G3PDH. Those 7/20 intact samples which did appear to overexpress G3PDH on Northern blot could not be detected by poly-T probing of dot blots. The apparent overexpression was not specific for the control gene G3PDH nor for the malignancy HCC. It may represent partial mRNA degradation, or the presence of as yet unknown substances which interfere with absorption at 260/280 nm. We advise caution in selecting human T/N pairs for differential gene expression studies. For HCC, no clinicopathological variables, including cirrhosis, predicted whether a T/N sample pair was likely to be balanced or not. 相似文献
58.
BACKGROUND: To examine the seasonality of suicides in Australia and New Zealand during the period 1981 to 1993. METHODS: A chi-square test and a harmonic analysis were used to detect the seasonality of the suicide data. RESULTS: The reduced amplitude and a smaller proportion of variance accounted for by seasonality suggested the seasonal effect on suicide is greatly diminished. The absence of biseasonal distribution of female suicides was also consistently found in the two countries. The finding was contrary to the reported results in seventies in many Western countries. CONCLUSIONS: The change in living condition, roles of males and females and communication pattern resulted in the reduction of climatic and environment effect in the seasonality of suicides were suggested. LIMITATIONS: The results would be better if a longer series of suicide date were available. 相似文献
59.
Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1 总被引:3,自引:0,他引:3
AK Nussbaum TP Dick W Keilholz M Schirle S Stevanovi? K Dietz W Heinemeyer M Groll DH Wolf R Huber HG Rammensee H Schild 《Canadian Metallurgical Quarterly》1998,95(21):12504-12509
The 436-amino acid protein enolase 1 from yeast was degraded in vitro by purified wild-type and mutant yeast 20S proteasome particles. Analysis of the cleavage products at different times revealed a processive degradation mechanism and a length distribution of fragments ranging from 3 to 25 amino acids with an average length of 7 to 8 amino acids. Surprisingly, the average fragment length was very similar between wild-type and mutant 20S proteasomes with reduced numbers of active sites. This implies that the fragment length is not influenced by the distance between the active sites, as previously postulated. A detailed analysis of the cleavages also allowed the identification of certain amino acid characteristics in positions flanking the cleavage site that guide the selection of the P1 residues by the three active beta subunits. Because yeast and mammalian proteasomes are highly homologous, similar cleavage motifs might be used by mammalian proteasomes. Therefore, our data provide a basis for predicting proteasomal degradation products from which peptides are sampled by major histocompatibility complex class I molecules for presentation to cytotoxic T cells. 相似文献
60.
T Nishida TP Huang A Seiyama E Hamada W Kamiike S Ueshima H Kazuo H Matsuda 《Canadian Metallurgical Quarterly》1998,115(2):412-420
BACKGROUND & AIMS: Endothelin 1 is considered to be an important regulator of sinusoidal blood flow and increases during endotoxemia. The purpose of this study was to investigate the role of endothelin 1 in hepatic microcirculation, oxygen transport, and liver injury during endotoxemia. METHODS: Male Sprague-Dawley rats were continuously infused with 2.5 mL/h of saline, 0.8 mg . kg-1 . h-1 of lipopolysaccharide (LPS), 3 mg . kg-1 . h-1 of BQ-485, an endothelin A-receptor antagonist, or LPS plus BQ-485 for 7 hours. RESULTS: BQ-485 infusion had no significant effect on hepatic microcirculation and liver injury. LPS increased the plasma levels of aspartate aminotransferase (AST) and total bilirubin and decreased the hepatic adenosine triphosphate (ATP) level and bile flow rate. LPS + BQ-485 infusion further increased the plasma levels of AST and total bilirubin and decreased the bile flow rate and the hepatic ATP level. Dual-spot microspectroscopy revealed mild decreases in sinusoidal erythrocyte velocity and oxygen transport in the LPS group and profound decreases in these parameters in the LPS + BQ-485 group. Histological examinations revealed massive necrotic changes in the pericentral regions of the LPS + BQ-485 group. CONCLUSIONS: These results suggest that blockade of endothelin A receptors disturbs hepatic microcirculation and oxygen transport and aggravates the necrotic injury induced by endotoxin. 相似文献