Nano-hydroxyapatite and nano-hydroxyapatite/zinc oxide scaffold for bone tissue engineering application

This research aims to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA-modified by ZnO for bone tissue engineering applications. HA and ZnO were developed using sol-gel and precipitation methods respectively. The scaffolds properties were characterized using X-ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), atomic absorption (AA), and atomic force microscopy (AFM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ZnO scaffolds possess higher compressive strength, fracture toughness, and density—but lower hardness—when compared to the pure HA scaffolds. After immersing the scaffold in the SBF solution, more deposited apatite appeared on the HA/ZnO, which results in the rougher surface on this scaffold compared to the pure HA scaffold. Finally, the in vitro biological analysis using human osteoblast cells reveals that scaffolds are biocompatible with adequate ALP activity.     

256-channel bidirectional optical interconnect using VCSELs andphotodiodes on CMOS

Two-dimensional parallel optical interconnects (2-D-POIs) are capable of providing large connectivity between elements in computing and switching systems. Using this technology we have demonstrated a bidirectional optical interconnect between two printed circuit boards containing optoelectronic (OE) very large scale integration (VLSI) circuits. The OE-VLSI circuits were constructed using vertical cavity surface emitting lasers (VCSELs) and photodiodes (PDs) flip-chip bump-bonded to a 0.35-μm complementary metal-oxide-semiconductor (CMOS) chip. The CMOS was comprised of 256 laser driver circuits, 256 receiver circuits, and the corresponding buffering and control circuits required to operate the large transceiver array. This is the first system, to our knowledge, to send bidirectional data optically between OE-VLSI chips that have both VCSELs and photodiodes cointegrated on the same substrate     

A 10-Gb/s CMOS clock and data recovery circuit with a half-ratelinear phase detector

A 10-Gb/s phase-locked clock and data recovery circuit incorporates an interpolating voltage-controlled oscillator and a half-rate phase detector. The phase detector provides a linear characteristic while retiming and demultiplexing the data with no systematic phase offset. Fabricated in a 0.18-μm CMOS technology in an area of 1.1×0.9 mm², the circuit exhibits an RMS jitter of 1 ps, a peak-to-peak jitter of 14.5 ps in the recovered clock, and a bit-error rate of 1.28×10^-6, with random data input of length 2²³-1. The power dissipation is 72 mW from a 2.5-V supply     

A 125-MHz mixed-signal echo canceller for Gigabit Ethernet oncopper wire

A discrete-time analog echo canceller is described that reduces the echo in the front end of Gigabit Ethernet twisted-pair interfaces. Echo cancellation in the analog domain by means of four taps reduces the complexity of the digital echo canceller and crosstalk cancellers. Designed in a 0.4-μm CMOS technology, the circuit employs an LMS algorithm to adapt to the cable length and impedance discontinuities, providing an echo suppression of 10 dB. The design operates at 125 MHz while consuming 43 mW from a 3-V supply     

A CMOS clock recovery circuit for 2.5-Gb/s NRZ data

This paper describes a phase-locked clock recovery circuit that operates at 2.5 Gb/s in a 0.4-μm digital CMOS technology. To achieve a high speed with low power dissipation, a two-stage ring oscillator is introduced that employs an excess phase technique to operate reliably across a wide range. A sample-and-hold phase detector is also described that combines the advantages of linear and nonlinear phase detectors. The recovered clock exhibits an rms jitter of 10.8 ps for a PRBS sequence of length 2⁷-1 and a phase noise of -80 dBc/Hz at a 5-MHz offset. The core circuit dissipates a total power of 33.5 mW from a 3.3-V supply and occupies an area of 0.8×0.4 mm²     

Plantaricin bacteriocins: As safe alternative antimicrobial peptides in food preservation—A review

Many peptides are excreted by gram-positive (+) and gram-negative (−) bacteria, possessing antimicrobial properties, called bacteriocins. Common bacterial species produce bacteriocins are called lactic acid bacteria. Nowadays, plantaricins are natural antimicrobial peptides produced by Lactobacillus plantarum strains have obtained special attention. The L. plantarum and their bacteriocins have got great importance in different areas as food biopreservatives and/or starters in dairy products, meat products, and fish products also, were used for treating diseases caused by pathogenic bacteria that is, reducing symptoms of irritable bowel syndrome disease (IBS) and decreasing the number of colonies of pathogenic bacteria in the wound-burning model in mice. Moreover, plantaricins have got a potent protective role against urinary tract infection (UTI). Although there are many studies on the types of bacteriocins and their purification and uses, such as Nisin and Pediocin, there have been no reports in the literature on the characterizations, production, and purification of plantaricins. The present review aims to describe plantaricins and some of their features and applications in general. Also mentioned are the most common methods of isolation and purification.     

A low-power 2.4-GHz transmitter/receiver CMOS IC

A 2.4-GHz CMOS receiver/transmitter incorporates circuit stacking and noninvasive baseband filtering to achieve a high sensitivity with low power dissipation. Using a single 1.6-GHz local oscillator, the transceiver employs two upconversion and downconversion stages while providing on-chip image rejection filtering. Realized in a 0.25-/spl mu/m digital CMOS technology, the receiver exhibits a noise figure of 6 dB and consumes 17.5 mW from a 2.5-V supply, and the transmitter delivers an output power of 0 dBm with a power consumption of 16 mW.     

The effect of orientations of metal macrofiber reinforcements on mechanical properties of adhesively bonded single lap joints

A method for improving the mechanical behavior of adhesive joints is embedding metal macrofibers to the adhesive layer. The effect of the orientation of metal macrofibers laid across the length and width of the joint (longitudinal and transversal directions) on the strength and elongation at failure of single lap joints (SLJs) was investigated experimentally by testing SLJs reinforced with metal macrofibers laid in different orientations. The experimental results indicated that increasing the number of metal macrofibers in the longitudinal direction improved the shear strength and elongation at failure of SLJs. However, the improvements were found to be dependent on the normalized horizontal distance between the metal macrofibers for which a proper value of 1 was determined. While embedding metal macrofibers in the transversal direction degraded the mechanical properties of SLJs. Finite element analyses were undertaken to investigate the effects of fibers orientation and horizontal distance on the adhesive peel and shear stress distributions. The results revealed that decreasing the horizontal distance between the metal macrofibers laid in the longitudinal direction decreased the adhesive shear stress values indicating improvement of the joint strength, while in SLJs reinforced with metal macrofibers laid in the transversal direction decreasing the fibers distance increased the adhesive peel stress values resulting in joint strength reduction.     

Design and manufacture of free-form surfaces by cross-sectional approach

Conventional methods for manual design and analysis are not necessarily the best methods for computer implementation, lofting techniques, or computer aided design to produce a satisfactory result for the design of a wide range of shapes and the general form of the B-spline curve with the defining polygon adequately fulfils most essential requirements. Fourth-order curves seemed to be best suited for most cases, as they provide a compromise between smoothness and ‘localness’, yet curve orders of varying degrees still have some merit in certain circumstances.The most attractive feature realized with this method is the simplicity of design and the determination of the main input elements. Surface interpolation curves are shown and the production of a mould for a plastic handle indicated.