This paper proposes an efficient hybrid approach for solving multi-objective optimization design of a compliant mechanism. The approach is developed by integrating desirability function approach, fuzzy logic system, adaptive neuro-fuzzy inference system, and Lightning attachment procedure optimization. Box–Behnken design is used to form a numerically experimental matrix. First, a refinement of design variables is conducted through analysis of variance and Taguchi approach in terms of considerably eliminating space of design variables and computation efforts. Next, desirability of two objective functions is computed and transferred into the fuzzy logic system. The output of fuzzy logic system is regarded as single combined objective function. Subsequently, a modeling for fuzzy output is developed via adaptive neuro-fuzzy inference system. Then, LAPO algorithm is adopted for solving the optimization problem. By investigating three different numerical examples, performance of the proposed approach is validated. Numerical results revealed that the proposed approach has a computational accuracy better than that of Taguchi-based fuzzy logic reasoning. Finally, case study 1 is chosen as an optimal solution for the mechanism. Furthermore, the effectiveness of proposed approach is greater than that of the Jaya algorithm and TLBO algorithm through Wilcoxon signed rank test and Friedman test. The proposed approach can be used for related engineering fields.
Uncertain data streams, where data are incomplete and imprecise, have been observed in many environments. Feeding such data streams to existing stream systems produces results of unknown quality, which is of paramount concern to monitoring applications. In this paper, we present the claro system that supports stream processing for uncertain data naturally captured using continuous random variables. claro employs a unique data model that is flexible and allows efficient computation. Built on this model, we develop evaluation techniques for relational operators by exploring statistical theory and approximation. We also consider query planning for complex queries given an accuracy requirement. Evaluation results show that our techniques can achieve high performance while satisfying accuracy requirements and outperform state-of-the-art sampling methods. 相似文献
Self-Organizing Map (SOM) possesses effective capability for visualizing high-dimensional data. Therefore, SOM has numerous applications in visualized clustering. Many growing SOMs have been proposed to overcome the constraint of having a fixed map size in conventional SOMs. However, most growing SOMs lack a robust solution to process mixed-type data which may include numeric, ordinal and categorical values in a dataset. Moreover, the growing scheme has an impact on the quality of resultant maps. In this paper, we propose a Growing Mixed-type SOM (GMixSOM), combining a value representation mechanism distance hierarchy with a novel growing scheme to tackle the problem of analyzing mixed-type data and to improve the quality of the projection map. Experimental results on synthetic and real-world datasets demonstrate that the proposed mechanism is feasible and the growing scheme yields better projection maps than the existing method. 相似文献
Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the salivary gland by a metabolomics approach in an extensive aging mouse model, SAMP1/Klotho -/- mice. We found that the salivary secretion of SAMP1/Klotho -/- mice was dramatically decreased compared with that of SAMP1/Klotho WT (+/+) mice. Metabolomics profiling analysis showed that the level of acetylcholine was significantly decreased in SAMP1/Klotho -/- mice, although the corresponding levels of acetylcholine precursors, acetyl-CoA and choline, increased. Interestingly, the mRNA and protein expression of choline acetyltransferase (ChAT), which is responsible for catalyzing acetylcholine synthesis, was significantly decreased in SAMP1/Klotho -/- mice. The overexpression of ChAT induced the expression of salivary gland functional markers (α–amylase, ZO-1, and Aqua5) in primary cultured salivary gland cells from SAMP1/Klotho +/+ and -/- mice. In an in vivo study, adeno-associated virus (AAV)-ChAT transduction significantly increased saliva secretion compared with the control in SAMP1/Klotho -/- mice. These results suggest that the dysfunction in acetylcholine biosynthesis induced by ChAT reduction may cause impaired salivary gland function 相似文献
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under SMG, but their mechanisms are still not fully understood. This study aimed to evaluate the effects of SMG on the proliferative ability and cytoskeleton changes of Chang Liver Cells (CCL-13). CCL-13 cells were induced SMG by 3D clinostat for 72 h, while the control group were treated in normal gravity at the same time. The results showed that SMG reduced CCL-13 cell proliferation by an increase in the number of CCL-13 cells in G0/G1 phase. This cell cycle phase arrest of CCL-13 cells was due to a downregulation of cell cycle-related proteins, such as cyclin A1 and A2, cyclin D1, and cyclin-dependent kinase 6 (Cdk6). SMG-exposed CCL-13 cells also exhibited a downregulation of α-tubulin 3 and β-actin which induced the cytoskeleton reorganization. These results suggested that the inhibited proliferation of SMG-exposed CCL-13 cells could be associate with the attenuation of major cell cycle regulators and main cytoskeletal proteins. 相似文献