C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation

C-reactive protein (CRP) is considered a biomarker of infection/inflammation. It is a commonly used tool for early detection of infection in the emergency room or as a point-of-care test and especially for differentiating between bacterial and viral infections, affecting decisions of admission and initiation of antibiotic treatments. As C-reactive protein is part of a dynamic and continuous inflammatory process, a single CRP measurement, especially at low concentrations, may erroneously lead to a wrong classification of an infection as viral over bacterial and delay appropriate antibiotic treatment. In the present review, we introduce the concept of C-reactive protein dynamics, measuring the velocity of C-reactive protein elevation, as a tool to increase this biomarker’s diagnostic ability. We review the studies that helped define new metrics such as estimated C-reactive protein velocity (velocity of C-reactive protein elevation from symptoms’ onset to first C-reactive protein measurement) and the measured C-reactive protein velocity (velocity between sequential C-reactive protein measurements) and the use of these metrics in different clinical scenarios. We also discuss future research directions for this novel metric.     

Spider Silk-CBD-Cellulose Nanocrystal Composites: Mechanism of Assembly

The fabrication of cellulose-spider silk bio-nanocomposites comprised of cellulose nanocrystals (CNCs) and recombinant spider silk protein fused to a cellulose binding domain (CBD) is described. Silk-CBD successfully binds cellulose, and unlike recombinant silk alone, silk-CBD self-assembles into microfibrils even in the absence of CNCs. Silk-CBD-CNC composite sponges and films show changes in internal structure and CNC alignment related to the addition of silk-CBD. The silk-CBD sponges exhibit improved thermal and structural characteristics in comparison to control recombinant spider silk sponges. The glass transition temperature (Tg) of the silk-CBD sponge was higher than the control silk sponge and similar to native dragline spider silk fibers. Gel filtration analysis, dynamic light scattering (DLS), small angle X-ray scattering (SAXS) and cryo-transmission electron microscopy (TEM) indicated that silk-CBD, but not the recombinant silk control, formed a nematic liquid crystalline phase similar to that observed in native spider silk during the silk spinning process. Silk-CBD microfibrils spontaneously formed in solution upon ultrasonication. We suggest a model for silk-CBD assembly that implicates CBD in the central role of driving the dimerization of spider silk monomers, a process essential to the molecular assembly of spider-silk nanofibers and silk-CNC composites.     

Face-Specific Data Augmentation for Unconstrained Face Recognition

International Journal of Computer Vision - We identify two issues as key to developing effective face recognition systems: maximizing the appearance variations of training images and minimizing...     

A Stretchable and Flexible Cardiac Tissue–Electronics Hybrid Enabling Multiple Drug Release,Sensing, and Stimulation

Replacement of the damaged scar tissue created by a myocardial infarction is the goal of cardiac tissue engineering. However, once the implanted tissue is in place, monitoring its function is difficult and involves indirect methods, while intervention necessarily requires an invasive procedure and available medical attention. To overcome this, methods of integrating electronic components into engineered tissues have been recently presented. These allow for remote monitoring of tissue function as well as intervention through stimulation and controlled drug release. Here, an improved hybrid microelectronic tissue construct capable of withstanding the dynamic environment of the beating heart without compromising electronic or mechanical functionality is reported. While the reported system is enabled to sense the function of the engineered tissue and provide stimulation for pacing, an electroactive polymer on the electronics enables it to release multiple drugs in parallel. It is envisioned that the integration of microelectronic devices into engineered tissues will provide a better way to monitor patient health from afar, as well as provide facile, more exact methods to control the healing process.     

Rational approach for the analysis of segmental reinforced soil walls based on kinematic constraints

The paper presents an analytical method for the solution of reinforced soil walls in which the wall facing has a structural role. The three-component (soil–reinforcement–wall) system is statically indeterminate, and hence cannot be solved by equilibrium equations alone. The paper follows up on the work of Baker and Klein [2004. An integrated limiting equilibrium approach for design of reinforced soil retaining structures part I – formulation. Geotextiles and Geomembranes 22, 119–150] where an interaction model, incorporating factors that divide forces between the reinforcement layers and the wall, was introduced to solve the statically indeterminate system. In the current work, the division factors are resolved such that the kinematic constraints of compatibility between the reinforcement layers and the wall are satisfied. This is achieved by solving an optimization problem in which the objective function includes the relative displacement between the reinforcement layers and the wall. The resultant system is fully coupled whereby upper reinforcement layers are affected by the behavior of lower layers. As such, the method overcomes the limitation of the original framework in which the top-down procedure omits such coupling. A non-dimensional parametric study was conducted on walls with 10 face blocks (9 reinforcement layers). Results are given in a normalized manner for cases in which the reinforcement pullout stiffness is uniform and linearly increasing with depth. Analysis results show that in cases where the wall is relatively stiff compared to the reinforcement, the upper reinforcement layers are clearly affected by the lower layers (this is a direct outcome of the fully coupled system). On the other hand, when the relative stiffness of the wall is low, the system behavior tends towards that of a hinged system, which is statically determinate. In this case the solution becomes independent of the reinforcement pullout stiffness. Analysis results indicate that current design codes, which do not explicitly consider the structural role of the facing in the calculation procedure, may be overconservative in certain cases. This result supports the argument for introducing the structural role of the facing into design procedures.     

The attentional white bear phenomenon: The mandatory allocation of attention to expected distractor locations.

The authors devised a prestimulus-probe method to assess the allocation of attention as a function of participants' top-down expectancies concerning distractor and target locations. Participants performed the flanker task, and distractor locations remained fixed. On some trials, instead of the flanker display, either 2 simultaneous dots or a horizontal line appeared. The dot in the expected distractor location was perceived to occur before the dot in the expected empty location, and the line appeared to extend from the expected distractor location to the expected empty location, suggesting that attention is allocated to expected distractor locations prior to stimulus onset. The authors propose that a process-all mechanism guides attention to expected locations of all stimuli regardless of task demands and that this constitutes a major cause for failures of selective attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fabrication and Characterization of Three‐Dimensional Silver‐Coated Polymeric Microstructures

A method is reported for fabricating complex 3D silver‐coated polymeric microstructures. The approach is based on the creation of a crosslinked polymeric microscaffold via patterned multiphoton‐initiated polymerization followed by surface‐nucleated electroless deposition of silver. The conductivity and reflectivity of the resulting silver–polymer composites and the nanoscale morphology of the deposited silver are characterized. Sub‐micrometer thick layers of silver can be controllably deposited onto surfaces, including those of 3D microporous forms without occluding the interior of the structure. The approach is general for silver coating crosslinked polymeric structures based on acrylate, methacrylate, and epoxide resins and provides a new path to complex 3D micrometer‐scale devices with electronic, photonic, and electromechanical function.     

Transient flow in response to a pressure pulse in gas chromatography

The analysis of flow through a gas chromatography column has traditionally assumed the presence of steady-state conditions. However, when rapid changes in inlet pressure are introduced, a significant transient period is observed, leading to a failure of the steady-state model. Through the introduction of a one-dimensional continuity equation into the basic set of equations, a nonlinear partial differential equation is derived to describe the evolution of pressure profiles in a capillary gas chromatography column. A numerical solution is used to solve the differential equation for the case of a pulse injection under isothermal conditions, and comparisons with experimental holdup and retention times show very good agreement.     

A survey on offline scheduling with rejection

In classical deterministic scheduling problems, it is assumed that all jobs have to be processed. However, in many practical cases, mostly in highly loaded make-to-order production systems, accepting all jobs may cause a delay in the completion of orders which in turn may lead to high inventory and tardiness costs. Thus, in such systems, the firm may wish to reject the processing of some jobs by either outsourcing them or rejecting them altogether. The field of scheduling with rejection provides schemes for coordinated sales and production decisions by grouping them into a single model. Since scheduling problems with rejection are very interesting both from a practical and a theoretical point of view, they have received a great deal of attention from researchers over the last decade. The purpose of this survey is to offer a unified framework for offline scheduling with rejection by presenting an up-to-date survey of the results in this field. Moreover, we highlight the close connection between scheduling with rejection and other fields of research such as scheduling with controllable processing times and scheduling with due date assignment, and include some new results which we obtained for open problems.