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271.
This paper presents a new algorithm for force directed graph layout on the GPU. The algorithm, whose goal is to compute layouts accurately and quickly, has two contributions. The first contribution is proposing a general multi-level scheme, which is based on spectral partitioning. The second contribution is computing the layout on the GPU. Since the GPU requires a data parallel programming model, the challenge is devising a mapping of a naturally unstructured graph into a well-partitioned structured one. This is done by computing a balanced partitioning of a general graph. This algorithm provides a general multi-level scheme, which has the potential to be used not only for computation on the GPU, but also on emerging multi-core architectures. The algorithm manages to compute high quality layouts of large graphs in a fraction of the time required by existing algorithms of similar quality. An application for visualization of the topologies of ISP (Internet Service Provider) networks is presented.  相似文献   
272.
273.
This paper presents a bicriterion analysis of time/cost trade-offs for the single-machine scheduling problem where both job processing times and release dates are controllable by the allocation of a continuously nonrenewable resource. Using the bicriterion approach, we distinguish between our sequencing criterion, namely the makespan, and the cost criterion, the total resource consumed, in order to construct an efficient time/cost frontier. Although the computational complexity of the problem of constructing this frontier remains an open question, we show that the optimal job sequence is independent of the total resource being used; thereby we were able to reduce the problem to a sequencing one. We suggest an exact dynamic programming algorithm for solving small to medium sizes of the problem, while for large-scale problems we present some heuristic algorithms that turned out to be very efficient. Five different special cases that are solvable by using polynomial time algorithms are also presented.  相似文献   
274.
    
Nano secondary ion mass spectrometry (nanoSIMS) imaging is a rapidly growing field in biological sciences, which enables investigators to describe the chemical composition of cells and tissues with high resolution. One of the major challenges of nanoSIMS is to identify specific molecules or organelles, as these are not immediately recognizable in nanoSIMS and need to be revealed by SIMS-compatible probes. Few laboratories have generated such probes, and none are commercially available. To address this, we performed a systematic study of probes initially developed for electron microscopy. Relying on nanoscale SIMS, we found that antibodies coupled to 6 nm gold particles are surprisingly efficient in terms of labeling specificity while offering a reliable detection threshold. These tools enabled accurate visualization and sample analysis and were easily employed in correlating SIMS with other imaging approaches, such as fluorescence microscopy. We conclude that antibodies conjugated to moderately sized gold particles are promising tools for SIMS imaging.  相似文献   
275.
    
Despite having been tagged as safe and beneficial, recent evidence remains inconclusive regarding the status of artificial sweeteners and their putative effects on gut microbiota. Gut microorganisms are essential for the normal metabolic functions of their host. These microorganisms communicate within their community and regulate group behaviors via a molecular system termed quorum sensing (QS). In the present study, we aimed to study the effects of artificial sweeteners on this bacterial communication system. Using biosensor assays, biophysical protein characterization methods, microscale thermophoresis, swarming motility assays, growth assays, as well as molecular docking, we show that aspartame, sucralose, and saccharin have significant inhibitory actions on the Gram-negative bacteria N-acyl homoserine lactone-based (AHL) communication system. Our studies indicate that these three artificial sweeteners are not bactericidal. Protein-ligand docking and interaction profiling, using LasR as a representative participating receptor for AHL, suggest that the artificial sweeteners bind to the ligand-binding pocket of the protein, possibly interfering with the proper housing of the native ligand and thus impeding protein folding. Our findings suggest that these artificial sweeteners may affect the balance of the gut microbial community via QS-inhibition. We, therefore, infer an effect of these artificial sweeteners on numerous molecular events that are at the core of intestinal microbial function, and by extension on the host metabolism.  相似文献   
276.
This paper studies two closely related online-list scheduling problems of a set of n jobs with unit processing times on a set of m multipurpose machines. It is assumed that there are k different job types, where each job type can be processed on a unique subset of machines. In the classical definition of online-list scheduling, the scheduler has all the information about the next job to be scheduled in the list while there is uncertainty about all the other jobs in the list not yet scheduled. We extend this classical definition to include lookahead abilities, i.e., at each decision point, in addition to the information about the next job in the list, the scheduler has all the information about the next h jobs beyond the current one in the list. We show that for the problem of minimizing the makespan there exists an optimal (1-competitive) algorithm for the online problem when there are two job types. That is, the online algorithm gives the same minimal makespan as the optimal offline algorithm for any instance of the problem. Furthermore, we show that for more than two job types no such online algorithm exists. We also develop several dynamic programming algorithms to solve a stochastic version of the problem, where the probability distribution of the job types is known and the objective is to minimize the expected makespan.  相似文献   
277.
We study a scheduling problem with rejection on a set of two machines in a flow-shop scheduling system. We evaluate the quality of a solution by two criteria: the first is the makespan and the second is the total rejection cost. We show that the problem of minimizing the makespan plus total rejection cost is NP-hard and for its solution we provide two different approximation algorithms, a pseudo-polynomial time optimization algorithm and a fully polynomial time approximation scheme (FPTAS). We also study the problem of finding the entire set of Pareto-optimal points (this problem is NP-hard due to the NP-hardness of the same problem variation on a single machine [20]). We show that this problem can be solved in pseudo-polynomial time. Moreover, we show how we can provide an FPTAS that, given that there exists a Pareto optimal schedule with a total rejection cost of at most R and a makespan of at most K, finds a solution with a total rejection cost of at most (1+?)R and a makespan value of at most (1+?)K. This is done by defining a set of auxiliary problems and providing an FPTAS algorithm to each one of them.  相似文献   
278.
Image-based animation of facial expressions   总被引:1,自引:0,他引:1  
We present a novel technique for creating realistic facial animations given a small number of real images and a few parameters for the in-between images. This scheme can also be used for reconstructing facial movies where the parameters can be automatically extracted from the images. The in-between images are produced without ever generating a three-dimensional model of the face. Since facial motion due to expressions are not well defined mathematically our approach is based on utilizing image patterns in facial motion. These patterns were revealed by an empirical study which analyzed and compared image motion patterns in facial expressions. The major contribution of this work is showing how parameterized “ideal” motion templates can generate facial movies for different people and different expressions, where the parameters are extracted automatically from the image sequence. To test the quality of the algorithm, image sequences (one of which was taken from a TV news broadcast) were reconstructed, yielding movies hardly distinguishable from the originals. Published online: 2 October 2002 Correspondence to: A. Tal Work has been supported in part by the Israeli Ministry of Industry and Trade, The MOST Consortium  相似文献   
279.
Intrinsic soil factors affect and are affected by the spatial variation of soil properties. Therefore, intrinsic soil factors may both characterize and serve as an indicator for soil taxonomy. Difficulties in inferring intrinsic soil properties hamper attempts to assess their variability, on both local and regional/broad scales. Radar remote sensing might facilitate a breakthrough in this field, due to its sensitivity to the soil water content. In this research, a raster Geographic Information System (GIS) methodology is developed for combining multi-temporal ERS-2 SAR and Landsat TM data, which allows the estimation of drying rate patterns in bare soil surfaces. The drying rates provide further indication about intrinsic soil properties. The multi-scale behaviour of soil-drying rates is described using the richness-area curves and characteristic curves are determined to four soil formations typical to a climatic gradient between Mediterranean and semi-arid environments in Israel. To the best of our knowledge, this is one of the first attempts to document the effect of intrinsic soil factors on the soil system at the regional scale. The results achieved here demonstrate the connection between drying rates, richness-area variation and soil hydraulic conductivity of the four soil formations.  相似文献   
280.
The superiority of intensive versus standard chemotherapy for aggressive (I: intermediate; H: high grade) NHL is still debated; increased antitumor activity may be counterbalanced by increased toxicity. We have designed a first-line five-drug regimen (vincristine, idarubicin, cyclophosphamide, etoposide and deflazacort), with the aim of potentiating the CHOP protocol without losing tolerability and ease of administration. Seventy-one patients (33% aged > or = 65) entered the study. CR was obtained in 66.7% of patients (I: 74%; H: 56%), PR in 19.7%: overall response rate was 86.4%. Six patients were resistant, two died during treatment. With a median follow up of two years, relapse has occurred in 14 patients (8 I, 6 H). At 3 years, overall survival was projected to be 62.5% (I 73.5%; H 31.4%), disease free survival 66% (I 71%, H 56.3%). No organ toxicity occurred. Myelosuppression was moderate, with a nadir on the 14th day. Febrile episodes occurred in 16% of courses, dose delay in 19% of courses; dose reduction in 3% of patients. No patient required hospitalization. G-CSF was only occasionally used. This regimen has shown a potent antitumor effect with an excellent tolerance, even in elderly patients.  相似文献   
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