Activity of carbided molybdena–alumina for CO2 hydrogenation

The relationship between the catalytic activity of carbided molybdena–alumina and the methane desorption from carbidic carbon through temperature-programmed surface reaction (TPSR) were studied. The effects of passivation and hydrogen treatment on the catalytic activities of molybdenum carbides for CO₂ hydrogenation were determined. When the 973 K-carbided catalyst was reduced at 773 K with hydrogen, the catalyst exhibited the highest activity for the reaction, the activity decreasing with increasing H₂ pretreatment temperature. Passivation of this catalyst decreased the reaction rate by 20%. TPSR results were correlated with the activity to reveal that molybdenum carbide with slightly deficient carbidic carbon (Mo₂C_0.962C_1.0) serves as an active site for CO₂ hydrogenation.     

Effects of super-powdered activated carbon pretreatment on coagulation and trans-membrane pressure buildup during microfiltration

As a pretreatment for membrane microfiltration (MF), the use of powdered activated carbon (PAC) with a particle size much smaller than that of conventional PAC (super-powdered PAC, or S-PAC) has been proposed to enhance the removal of dissolved substances. In this paper, another advantage of S-PAC as a pretreatment for MF is described: the use of S-PAC attenuates trans-membrane pressure increases during the filtration operation. The floc particles that formed during coagulation preceded by S-PAC pretreatment were larger and more porous than the floc particles formed during coagulation preceded by PAC pretreatment and those formed during coagulation without pretreatment. This result was due to increased particle–particle collision frequency and better removal of natural organic matter, which inhibits coagulation by consuming coagulant, before the coagulation reaction. The caked fouling layer that built up on the membrane surface was thus more permeable with S-PAC than with normal PAC. Both physically reversible and irreversible membrane foulings were reduced, and more stable filtration was accomplished with S-PAC pretreatment.     

夸特罗科蒂商务中心 俄罗斯圣彼德堡

正夸特罗科蒂(QuattroCorti)商务中心落成于俄罗斯古城圣彼德堡,紧邻圣以撒大教堂。该项目是在保留原有两座大楼立面的基础上,构造新的现代化建筑。设计以新型金属结构屋顶重新连接了原有建筑斜坡式的楼顶。屋顶在选材和形状上与城市天际线完美相融。屋顶之下是四个庭院,既保证了内部空间享有充足光源,又可以用于举行艺术造型、展览等公共活动。庭院立面覆盖以角度不同的反光玻璃板。由于角     

Estimation method of systematic uncertainties in Monte Carlo particle transport simulation based on analysis of variance

In the present work, the authors propose a standard analytical method to estimate systematic uncertainties in the Monte Carlo particle transport simulation based on analysis of variance (ANOVA). As sample problems, two sets of neutron-shielding calculations for evaluating effective dose were performed using the Particle and Heavy Ion Transport code System coupled with ANOVA. In the simulation, we selected the total cross section and the water density in material as unclear physical quantities to induce systematic uncertainties. Systematic and statistical uncertainties were evaluated by changing the number of simulation conditions and trials per condition, where each condition is associated with one set of unclear quantities. Then, we analyzed the dependence of convergence of the systematic uncertainties on the number of conditions and trials. The analysis results show that simulations with only three conditions are adequate in the case where variations in the conditions have a monotonic effect on the calculation results, while more than 100 conditions are required in the other cases. In addition, we propose a useful criterion to determine the appropriate number of trials for converging systematic uncertainties.     

Zoledronic Acid-Loaded β-TCP Inhibits Tumor Proliferation and Osteoclast Activation: Development of a Functional Bone Substitute for an Efficient Osteosarcoma Treatment

Osteosarcoma has a poor survival rate due to relapse and metastasis. Zoledronic acid (ZOL), an anti-resorptive and anti-tumor agent, is used for treating osteosarcoma. Delivery of ZOL to the target region is difficult due to its high binding affinity to bone minerals. This study developed a novel treatment for osteosarcoma by delivering ZOL to the target region locally and sustainably. In this study, we fabricated a novel bone substitute by loading ZOL on β-tricalcium phosphate (β-TCP). The ZOL-loaded β-TCP (ZOL/β-TCP) would be expected to express the inhibitory effects via both bound-ZOL (bound to β-TCP) and free-ZOL (release from ZOL/β-TCP). To explore the ability to release ZOL from the ZOL/β-TCP, the amount of released ZOL was measured. The released profile indicates that a small amount of ZOL was released, and most of it remained on the β-TCP. Our data showed that ZOL/β-TCP could successfully express the effects of ZOL via both bound-ZOL and free-ZOL. In addition, we examined the biological effects of bound/free-ZOL using osteosarcoma and osteoclasts (target cells). The results showed that two states of ZOL (bound/free) inhibit target cell activities. As a result, ZOL/β-TCP is a promising candidate for application as a novel bone substitute.     

Features of Particle and Heavy Ion Transport code System (PHITS) version 3.02

We have upgraded many features of the Particle and Heavy Ion Transport code System (PHITS) and released the new version as PHITS3.02. The accuracy and the applicable energy ranges of the code were greatly improved and extended, respectively, owing to the revisions to the nuclear reaction models and the incorporation of new atomic interaction models. Both condense history and track-structure methods were implemented to handle the electron and positron transport, although the latter is reliable only for simulations in liquid water. In addition, several user-supportive functions were developed, such as new tallies to efficiently obtain statistically better results, radioisotope source-generation function, and software tools useful for applying PHITS to medical physics. Owing to the continuous improvement and promotion of the code, the number of registered users has exceeded 3,000, and it is being used in diverse areas of study, including accelerator design, radiation shielding and protection, medical physics, and cosmic-ray research. In this paper, we summarize the basic features of PHITS3.02, especially those of the physics models and the functions implemented after the release of PHITS2.52 in 2013.     

Monitoring the microbial population dynamics at the start-up stage of wastewater treatment reactor by terminal restriction fragment length polymorphism analysis based on 16S rDNA and rRNA gene sequences

The microbial population dynamics at the start-up stage of a wastewater treatment reactor was investigated using terminal restriction fragment length polymorphism (T-RFLP) analysis based on 16S rDNA and rRNA gene sequences. The results of fragment peaks suggested that the number and activity of nitrifying bacteria increased in association with the start of nitrification, and the relative ratios of 16S rRNA of these bacteria changed prior to those of the 16S rDNA. Furthermore, multidimensional scaling (MDS) analysis revealed that the 16S rRNA exhibited wider dispersion than the 16S rDNA at the start-up stage, indicating that the diversity of 16S rRNA in the microbial communities was strongly affected by environmental changes.     

Loads carrying capacity map for the surface texture design of SiC thrust bearing sliding in water

Water lubricated silicon carbide is expected to be widely used for sliding bearings and mechanical seals in hydraulic systems since it is environmentally friendly and saves energy. The purpose of this study is to find the optimum surface texture to improve the load carrying capacity of SiC bearings working in water. Micro-pits, evenly distributed in a square array, were selected as the texture pattern, and formed on one of the contact surfaces by reactive ion etching. Experiments, which simulate the working condition of thrust bearings, were carried out to evaluate the effects of the micro-pits on the critical load of the transition of the lubrication mode from hydrodynamic to mixed. The results are summarized in the form of a load carrying capacity map. It was found that an optimum geometric and distributive range of micro-pits exists, where the load carrying capacity can be increased at least twice over that of an untextured surface.     

Low-Temperature Synthesis of Aluminum Silicon Carbide Using Ultrafine Aluminum Carbide and Silicon Carbide Powders

The conditions for preparing α-aluminum silicon carbide (α-Al₄SiC₄) were examined by heating stoichiometric mixtures of ultrafine A1₄C₃ and SiC powders with sizes of <0.1 μm at and below 1600°C. The starting A1₄C₃ powder was obtained by the pyrolysis of trimiethylaluminum; the starting SiC powders were obtained by the pyrolyses of triethylsilane (3ES), tetraethylsilane (4ES), and hexamethyldisilane (6MDS). The reactivity of SiC with Al₄C₃ to form α-Al₄SiC₄ varies according to the kind of starting alkylsilane: 3ES > 4ES > 6MDS. The reaction of 3ES-derived SiC with A1₄C₃ produced α-Al₄SiC₄ at temperatures as low as 1400°C for 240 min, regardless of the presence of A1₄C₃ (trace). Only α-Al₄SiC₄ was formed at and above 1500°C for 60 min; the crystal growth was appreciable.     

Influence of Culture Period on Osteoblast Differentiation of Tissue-Engineered Bone Constructed by Apatite-Fiber Scaffolds Using Radial-Flow Bioreactor

With the limitation of autografts, the development of alternative treatments for bone diseases to alleviate autograft-related complications is highly demanded. In this study, a tissue-engineered bone was formed by culturing rat bone marrow cells (RBMCs) onto porous apatite-fiber scaffolds (AFSs) with three-dimensional (3D) interconnected pores using a radial-flow bioreactor (RFB). Using the optimized flow rate, the effect of different culturing periods on the development of tissue-engineered bone was investigated. The 3D cell culture using RFB was performed for 0, 1 or 2 weeks in a standard medium followed by 0, 1 or 2 weeks in a differentiation medium. Osteoblast differentiation in the tissue-engineered bone was examined by alkaline phosphatase (ALP) and osteocalcin (OC) assays. Furthermore, the tissue-engineered bone was histologically examined by hematoxylin and eosin and alizarin red S stains. We found that the ALP activity and OC content of calcified cells tended to increase with the culture period, and the differentiation of tissue-engineered bone could be controlled by varying the culture period. In addition, the employment of RFB and AFSs provided a favorable 3D environment for cell growth and differentiation. Overall, these results provide valuable insights into the design of tissue-engineered bone for clinical applications.