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51.
论文对我国社会主义市场经济形势下设计单位管理现状进行了分析,对在设计单位推广项目经理负责制的设计组织形式、项目经理的职责及如何发挥项目经理的作用等方面进行了初步探讨。 相似文献
52.
C. M. Dinnis A. K. Dahle J. A. Taylor M. O. Otte 《Metallurgical and Materials Transactions A》2004,35(11):3531-3541
Strontium modification is known to alter the amount, characteristics, and distribution of porosity in Al-Si castings. Although
many theories have been proposed to account for these effects, most can be considered inadequate because of their failure
to resolve contradictions and discrepancies in the literature. In an attempt to critically appraise some of these theories,
the amount, distribution, and morphology of porosity were examined in sand-cast plates of Sr-free and Sr-containing pure Al,
Al-1 wt pct Si, and Al-9 wt pct Si alloys. Statistical significance testing was used to verify apparent trends in the porosity
data. No apparent differences in the amount, distribution, and morphology of porosity were observed between Sr-free and Sr-containing
alloys with no or very small eutectic volume fractions. However, Sr modification significantly changed the amount, distribution,
and morphology of porosity in alloys with a significant volume fraction of eutectic. The addition of Sr reduced porosity in
the hot spot region of the casting, and the pores became well dispersed and rounded. This result can be explained by considering
the combined effect of the casting design and the differences in the pattern of eutectic solidification between unmodified
and Sr-modified alloys. 相似文献
53.
54.
R Ravichandran F Lafferty MJ McGinniss HC Taylor 《Canadian Metallurgical Quarterly》1996,81(5):1776-1779
Divergent recommendations exist regarding the evaluation of adrenal incidentalomas. Recent data have indicated a prevalence of adrenal tumors of 71% in nonclassical congenital adrenal hyperplasia (CAH) and unmasked heterozygotes. These data expand the differential diagnosis of such incidental tumors and substantially modify the approach to their evaluation. We present two patients, female pseudohermaphrodites with the simple virilizing form of CAH and 21-hydroxylase deficiency, who functioned successfully as married phenotypic males. Both came to medical attention in the sixth decade by virtue of massive adrenal incidentalomas encountered in the evaluation of recurrent urinary tract infections. Each had a 46, XX karyotype, no palpable testes, and markedly elevated baseline levels of 17-hydroxyprogesterone (17-OH Prog) of 6086 ng/dL and 6750 ng/dL. Both responded appropriately to dexamethasone suppression with reduction of 17-OH Prog, androgens and, in the second patient, ACTH to normal or near normal levels. Histologic and autopsy examination of the first patient's tumor and computed tomographic characteristics of the second revealed a benign adenoma and myelolipoma respectively. We extend and confirm previous recommendations that CAH be included in the differential diagnosis of adrenal incidentaloma and that baseline 17-OH Prog. levels be obtained, with ACTH stimulation if necessary, to diagnose the presence of nonclassical CAH. 相似文献
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58.
The two gene-duplicated cAMP binding domains in the regulatory subunits of cAMP dependent protein kinase are each comprised of an A helix, an eight-stranded beta-barrel, and a B and C helix (1). The A domain is required for high affinity binding to C, while the B domain regulates access to the A domain. Using a combination of a yeast two-hybrid screen coupled with deletion analysis, cAMP binding domain A of RI was dissected into two structurally and functionally distinct subsites, one that binds cAMP and another that binds the C subunit. The minimum stable subdomain required for binding to C in the 1-3 micromolar range is composed of residues 94-169, while residues 236-244, mapped to the C helix of cAMP binding domain A, were defined as a second surface necessary for high affinity (5-10 nanomolar) binding to C. This portion of the C helix, due to its position directly between the two subsites, serves as a molecular switch for either a cAMP-bound conformation or a C-bound conformation and can thus modulate interactions of cAMP binding domain A with cAMP, with C, and with cAMP binding domain B. 相似文献
59.
AN Salt MM Henson SL Gewalt AW Keating JE DeMott OW Henson 《Canadian Metallurgical Quarterly》1995,88(1-2):79-86
The experiments carried out on the model of immobilization stress permit establishing the antiulcer effect of preventive introduction of sodium succinate solution, milk serum solution and solution of milk serum with sodium succinate. A decrease in the degree and number of ulcers and in the integrative indices characterizing the ulcer process after introduction of the studied drugs was accompanied by a fall of the intensity of lipid peroxidation processes. 相似文献
60.
Generation of 100 GHz trains of 500-700 fs pulses using dual-frequency beat conversion in a step-like dispersion profiled fibre is reported. The authors believe that this is the first time the generation and compression of soliton pulses using such a fibre has been demonstrated. The fabrication of such fibre assemblies does not require any special facilities and relies only on conventional optical fibre technology. They believe that the use of profiling the fibre dispersion by fibre segments instead of continuously dispersion-decreasing fibre is not only possible but preferable in many applications 相似文献