A deterministic sequential maximin Latin hypercube design method using successive local enumeration for metamodel-based optimization

Space-filling and projective properties of design of computer experiments methods are desired features for metamodelling. To enable the production of high-quality sequential samples, this article presents a novel deterministic sequential maximin Latin hypercube design (LHD) method using successive local enumeration, notated as sequential-successive local enumeration (S-SLE). First, a mesh-mapping algorithm is proposed to map the positions of existing points into the new hyper-chessboard to ensure the projective property. According to the maximin distance criterion, new sequential samples are generated through successive local enumeration iterations to improve the space-filling uniformity. Through a number of comparative studies, several appealing merits of S-SLE are demonstrated: (1) S-SLE outperforms several existing LHD methods in terms of sequential sampling quality; (2) it is flexible and robust enough to produce high-quality multiple-stage sequential samples; and (3) the proposed method can improve the overall performance of sequential metamodel-based optimization algorithms. Thus, S-SLE is a promising sequential LHD method for metamodel-based optimization.     

交互性在提升电商网站用户忠诚中的应用策略分析

目的对电商网站的交互性进行分析。方法通过文献调研划分交互行为,在竞品分析和深度访谈等定性研究的基础上,编撰调查问卷并开展大规模调查,回收定量数据,结合电商网站的特性,运用SPSS主成分分析法对交互因子进行提取研究。结论电商网站的交互因子可以概括为相关性、真实性和关系性3个方向,从信息交互和社会交互两个维度有针对性地探索各交互因子的应用策略,可以有效提升电商网站的用户忠诚。     

DOC‐LS,a new liposome for dermal delivery,and its endocytosis by HaCaT and CCC‐ESF‐1 cells

The main objective of this work was to investigate the uptake channels of skin cells through which coumarin 6, transported by deoxycholate‐mediated liposomes (DOC‐LS), was internalised; this was also compared against the action of conventional LS. Coumarin 6‐loaded DOC‐LS and LS were characterised for size distribution, zeta potential, and shape, and analysed in vitro in human epidermal immortal keratinocyte (HaCaT) (epidermal) and human embryonic skin fibroblast (CCC‐ESF‐1) (dermal) cell lines. Various endocytosis inhibitors were incubated with cells treated with the nanocarriers. Flow cytometry results indicated that HaCaT and CCC‐ESF‐1 cells internalise the tested preparations through pinocytotic vesicles, macropinocytosis, clathrin‐mediated endocytic pathways, and via lysosomes, which consume a considerable amount of energy. The endocytosis pathways of DOC‐LS and LS showed no difference. This study provides a basis for the application of LS being combined with a microneedle system for efficient intracellular drug delivery, targeting cutaneous histocyte disorders.Inspec keywords: drugs, nanoparticles, lipid bilayers, nanomedicine, biomedical materials, electrokinetic effects, biomembrane transport, drug delivery systems, skin, organic compoundsOther keywords: dermal delivery, CCC‐ESF‐1 cells, skin cells, deoxycholate‐mediated liposomes, coumarin 6‐loaded DOC‐LS, endocytosis inhibitors, clathrin‐mediated endocytic pathways, endocytosis pathways, HaCaT cell lines, size distribution, zeta potential, nanocarriers, flow cytometry, pinocytotic vesicles, macropinocytosis, microneedle system, efficient intracellular drug delivery, targeting cutaneous histocyte disorders     

Revisiting the security of secure direct communication based on ping-pong protocol[Quantum Inf. Process. 8, 347 (2009)]

A. Chamoli and C.M. Bhandari presented a secure direct communication based on ping-pong protocol[Quantum Inf. Process. 8, 347 (2009)]. M.Naseri analyzed its security and pointed out that in this protocol any dishonest party can obtain all the other one’s secret message with zero risk of being detected by using fake entangled particles (FEP attack) [M. Naseri, Quantum Inf. Process. online]. In this letter, we reexamine the protocol’s security and discover that except the FEP attack, using a special property of GHZ states, any one dishonest party can also take a special attack, i.e., double-CNOT(Controlled NOT) attack. Finally, a denial-of-service attack is also discussed.     

基于以太网的RS-485总线构造物联网系统可行性的探析

RS485总线是工业中常用的通讯总线,相比RS232总线,其具有传输距离远、成本低等优势;以太网是互联网中最主流的组网方式。通过RS485总线与以太网混合,构建物联网系统,可低成本高效率地整合校园内各末端设备和设施。     

中心扩散法局部区域纹理映射

为更好地实现对三维模型局部细节的描写,提出一种中心扩散局部区域纹理映射方法.该方法以初始种子面为中心,采用广度优先搜索方法扩散确定待映射区域,保证待映射区域获得更好的圆度.在实现根据初始种子面的位置变化改变映射区域位置的同时,可始终保证纹理图像中心与纹理映射区域中心的对应,避免了纹理图像中心在纹理映射区域的中心偏移问题.实验结果表明了该方法的可行性.     

Impact of DEM accuracy and resolution on topographic indices

Topography is an important land-surface characteristic that affects most aspects of the water balance in a catchment, including the generation of surface and sub-surface runoff; the flow paths followed by water as it moves down and through hillslopes and the rate of water movement. All of the spatially explicit fully distributed hydraulic and hydrological models use topography (represented by the DEM of the area modelled) to derive bathymetry. DEM is also used to derive some other key information critical in fully distributed hydraulic and hydrological models.With high-resolution DEMs such as LiDAR (Light Detection and Ranging) becoming more readily available and also with the advancements in computing facilities which can handle these large data sets, there is a need to quantify the impact of using different resolution DEMs (e.g. 1 m against 10 m or 25 m) on hydrologically important variables and the loss of accuracy and reliability of the results as we move from high resolution to coarser resolution.The results from statistical analysis carried out to compare field survey elevations with the LiDAR DEM-derived elevations, show that there are small differences between the two data sets but LiDAR DEM is a reasonably good representation of the actual ground surface compared to other commonly used DEMs derived from contour maps.The results from the analysis clearly show that the accuracy and resolution of the input DEM have serious implications on the values of the hydrologically important spatial indices derived from the DEM. The result also indicates that the loss of details by re-sampling the higher resolution DEM to coarser resolution are much less compared to the details captured in the commonly available coarse resolution DEM derived from contour maps. Topographic indices based on contour derived DEMs should be used with caution and where available, the higher resolution DEM should be used instead of the coarse resolution one.     

Globally Exponential Stability for Delayed Neural Networks Under Impulsive Control

In this paper, the dynamic behaviors of a class of neural networks with time-varying delays are investigated. Some less weak sufficient conditions based on p-norm and ∞-norm are obtained to guarantee the existence, uniqueness of the equilibrium point for the addressed neural networks without impulsive control by applying homeomorphism theory. And then, by utilizing inequality technique, Lyapunov functional method and the analysis method, some new and useful criteria of the globally exponential stability with respect to the equilibrium point under impulsive control we assumed are derived based on p-norm and ∞-norm, respectively. Finally, an example with simulation is given to show the effectiveness of the obtained results.