Detection of aircraft below the horizon for vision‐based detect and avoid in unmanned aircraft systems

Vision‐based aircraft detection technology may provide a credible sensing option for automated detect and avoid in small‐to‐medium size fixed‐wing unmanned aircraft systems (UAS). Reliable vision‐based aircraft detection has previously been demonstrated in sky‐region sensing environments. This paper describes a novel vision‐based system for detecting aircraft below the horizon in the presence of ground clutter. We examine the performance of our system on a data set of 63 near collision encounters we collected between a camera‐equipped manned aircraft and a below‐horizon target. In these 63 encounters, our system successfully detects all aircraft, at an average detection range of 1890 m (with a standard error of 43 m and no false alarms in 1.1 h). Furthermore, our system does not require access to inertial sensor data (which significantly reduces system cost) and operates at over 12 frames per second.     

Hyperinsulinemic Hypoglycemia Associated with a CaV1.2 Variant with Mixed Gain- and Loss-of-Function Effects

The voltage-dependent L-type calcium channel isoform Ca_V1.2 is critically involved in many physiological processes, e.g., in cardiac action potential formation, electromechanical coupling and regulation of insulin secretion by beta cells. Gain-of-function mutations in the calcium voltage-gated channel subunit alpha 1 C (CACNA1C) gene, encoding the Ca_V1.2 α₁-subunit, cause Timothy syndrome (TS), a multisystemic disorder that includes autism spectrum disorders and long QT (LQT) syndrome. Strikingly, TS patients frequently suffer from hypoglycemia of yet unproven origin. Using next-generation sequencing, we identified a novel heterozygous CACNA1C mutation in a patient with congenital hyperinsulinism (CHI) and associated hypoglycemic episodes. We characterized the electrophysiological phenotype of the mutated channel using voltage-clamp recordings and in silico action potential modeling experiments. The identified Ca_V1.2^L566P mutation causes a mixed electrophysiological phenotype of gain- and loss-of-function effects. In silico action potential modeling supports that this mixed electrophysiological phenotype leads to a tissue-specific impact on beta cells compared to cardiomyocytes. Thus, CACNA1C variants may be associated with non-syndromic hyperinsulinemic hypoglycemia without long-QT syndrome, explained by very specific electrophysiological properties of the mutated channel. We discuss different biochemical characteristics and clinical impacts of hypoglycemia in the context of CACNA1C variants and show that these may be associated with significant morbidity for Timothy Syndrome patients. Our findings underline that the potential of hypoglycemia warrants careful attention in patients with CACNA1C variants, and such variants should be included in the differential diagnosis of non-syndromic congenital hyperinsulinism.     

S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway

Metastasis is a leading cause of mortality and poor prognosis in colorectal cancer (CRC). Thus, the identification of new compounds targeting cell migration represents a major clinical challenge. Recent findings evidenced a central role for dysregulated Notch in CRC and a correlation between Notch overexpression and tumor metastasis. MicroRNAs (miRNAs) have been reported to cross-talk with Notch for its regulation. Therefore, restoring underexpressed miRNAs targeting Notch could represent an encouraging therapeutic approach against CRC. In this context, S-adenosyl-L-methionine (AdoMet), the universal biological methyl donor, being able to modulate the expression of oncogenic miRNAs could act as a potential antimetastatic agent. Here, we showed that AdoMet upregulated the onco-suppressor miRNAs-34a/-34c/-449a and inhibited HCT-116 and Caco-2 CRC cell migration. This effect was associated with reduced expression of migration-/EMT-related protein markers. We also found that, in colorectal and triple-negative breast cancer cells, AdoMet inhibited the expression of Notch gene, which, by luciferase assay, resulted the direct target of miRNAs-34a/-34c/-449a. Gain- and loss-of-function experiments with miRNAs mimics and inhibitors demonstrated that AdoMet exerted its inhibitory effects by upregulating miRNAs-34a/-34c/-449a. Overall, these data highlighted AdoMet as a novel Notch inhibitor and suggested that the antimetastatic effects of AdoMet involve the miRNA-mediated targeting of Notch signaling pathway.     

DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin

Erythropoietin (EPO) signaling plays a vital role in erythropoiesis by regulating proliferation and lineage-specific differentiation of murine hematopoietic progenitor cells (HPCs). An important downstream response of EPO signaling is calcium (Ca²⁺) influx, which is regulated by transient receptor potential channel (TRPC) proteins, particularly TRPC2 and TRPC6. While EPO induces Ca²⁺ influx through TRPC2, TRPC6 inhibits the function of TRPC2. Thus, interactions between TRPC2 and TRPC6 regulate the rate of Ca²⁺ influx in EPO-induced erythropoiesis. In this study, we observed that the expression of TRPC6 in KIT-positive erythroid progenitor cells was regulated by DOT1L. DOT1L is a methyltransferase that plays an important role in many biological processes during embryonic development including early erythropoiesis. We previously reported that Dot1l knockout (Dot1l^KO) HPCs in the yolk sac failed to develop properly, which resulted in lethal anemia. In this study, we detected a marked downregulation of Trpc6 gene expression in Dot1l^KO progenitor cells in the yolk sac compared to the wild type (WT). The promoter and the proximal regions of the Trpc6 gene locus exhibited an enrichment of H3K79 methylation, which is mediated solely by DOT1L. However, the expression of Trpc2, the positive regulator of Ca²⁺ influx, remained unchanged, resulting in an increased TRPC2/TRPC6 ratio. As the loss of DOT1L decreased TRPC6, which inhibited Ca²⁺ influx by TRPC2, Dot1l^KO HPCs in the yolk sac exhibited accelerated and sustained elevated levels of Ca²⁺ influx. Such heightened Ca²⁺ levels might have detrimental effects on the growth and proliferation of HPCs in response to EPO.     

A water coverage extraction approach to track inundation in the Saskatchewan River Delta,Canada

Tracking surface water coverage changes is a complicated task for many regions of the world. It is, however, essential to monitor the associated biological changes and bioproductivity. We present a methodology to track contemporary water coverage changes using optical remote sensing and use it to estimate historical summer water coverage in a large river delta. We used a geographical information system automated routine, based on the modified normalized difference water index, to extract the surface water coverage area (SWCA) from optical satellite data sets using the surface water extraction coverage area tool (SWECAT). It was applied to measure SWCA during drought and flood peaks in the Saskatchewan River Delta in Canada, from Landsat, SPOT and RapidEye images. Landsat results compared favourably with Canadian National Hydro Network (CNHN) GeoBase data, with deviations between SWCA classifications and the base CNHN GeoBase shapefile of ~2%. Difference levels between the extracted SWCA layer from Landsat and the higher resolution commercial satellites (SPOT and RapidEye) were also less than 2%. SWCA was tightly linked to discharge and level measurements from in-channel gauges (r² > 0.70). Using the SWCA versus discharge relationship for the gauge with the longest record, we show that peak summer SWCA has declined by half over the last century, from 13% of our study area to 6%, with likely implications for fish and wildlife production.     

Personality–cognition relations across adulthood.

Although an increasing number of studies have investigated relations between dimensions of personality and level of cognitive functioning, the research results have been somewhat inconsistent. Furthermore, relatively little is known about whether the personality–cognition relations vary as a function of age in adulthood. The current project examined these issues with data from a sample of 2,317 adults between 18 and 96 years of age who each completed a personality inventory and performed a broad battery of cognitive tests. The results revealed strong relations of the personality trait of Openness with several distinct cognitive abilities and smaller relations of other personality traits with specific cognitive abilities. Comparisons across different age groups indicated that the personality–cognition relations were both qualitatively and quantitatively similar across the adult years. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Two-Dimensional Fast-Response Flood Modeling: Desktop Parallel Computing and Domain Tracking

Emergency flood management is enhanced by using models that can estimate the timing and location of flooding. Typically, flood routing and inundation prediction is accomplished by using one-dimensional (1D) models. These have been the models of choice because they are computationally simple and quick. However, these models do not adequately represent the complex physical processes present for shallow flows located in the floodplain or in urban areas. Two-dimensional (2D) models developed on the basis of the full hydrodynamic equations can be used to represent the complex flow phenomena that exist in the floodplain and are, therefore, recommended by the National Research Council for increased use in flood analysis studies. The major limitation of these models is the increased computational cost. Two-dimensional flood models are prime candidates for parallel computing, but traditional methods/equipment (e.g., message passing paradigm) are more complex in terms of code refactoring and hardware setup. In addition, these hardware systems may not be available or accessible to modelers conducting flood analyses. This paper presents a 2D flood model that implements multithreading for use on now-prevalent multicore computers. This desktop parallel computing architecture has been shown to decrease computation time by 14 times on a 16-processor computer and, when coupled with a wet cell tracking algorithm, has been shown to decrease computation by as much as 310 times. These accomplishments make high-fidelity flood modeling more feasible for flood inundation studies using readily available desktop computers.     

When it comes to pay, do the thin win? The effect of weight on pay for men and women.

Cultivation theory suggests that society holds very different body standards for men versus women, and research indicates that the consequences of defying these social norms may not be linear. To test these notions in the employment context, we examined the relationship between weight and income and the degree to which the relationship varies by gender. For women, we theorized a negative weight–income relationship that is steepest at the thin end of the distribution. For men, we predicted a positive weight–income relationship until obesity, where it becomes negative. To test these hypotheses, we utilized 2 longitudinal studies, 1 German and 1 American. In Study 1, weight was measured over 2 time periods, and earnings were averaged over the subsequent 5 years. Study 2 was a multilevel study in which weight and earnings were within-individual variables observed over time, and gender was a between-individual variable. Results from the 2 studies generally support the hypotheses, even when examining within-individual changes in weight over time. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The influence of general identity disturbance on reports of lifetime substance use disorders and related outcomes among sexual minority adults with a history of substance use.

Previous research has shown that sexual minority (i.e., nonheterosexual) individuals report increased problematic substance use involvement, compared with their sexual majority counterparts. We hypothesize that feelings of an unstable sense of self (i.e., identity disturbance) may potentially drive problematic substance use. The purpose of the current study is to examine identity disturbance among sexual minorities as a potential explanatory mechanism of increased sexual minority lifetime rates of substance dependence. Measures of identity disturbance and three indicators of sexual orientation from lifetime female (n = 16,629) and male (n = 13,553) alcohol/illicit drug users in Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Findings generally showed that the increased prevalence of alcohol dependence, illicit drug dependence, and combined alcohol/illicit drug dependence as well as a younger age of alcohol use initiation among sexual minority women was associated with elevated levels of identity disturbance. The results were consistent with a mediational role for identity disturbance in explaining the association between sexual minority status and substance dependence and were generally replicated among male sexual minority respondents. The current research suggests that identity disturbance, a predictor of substance use, may contribute to heightened risk for substance dependence among certain subgroups of sexual minority individuals. (PsycINFO Database Record (c) 2011 APA, all rights reserved)