Possible Role of GnIH as a Novel Link between Hyperphagia-Induced Obesity-Related Metabolic Derangements and Hypogonadism in Male Mice

Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis and reproduction. However, whether GnIH is a molecular signal link of metabolism and the reproductive system, and thus, regulates reproductive activity as a function of the energy state, is still unknown. In the present study, we investigated the involvement of GnIH in glycolipid metabolism and reproduction in vivo, and in the coupling between these two processes in the testis level. Our results showed that chronic intraperitoneal injection of GnIH into male mice not only increased food intake and altered meal microstructure but also significantly elevated body mass due to the increased mass of liver and epididymal white adipose tissue (eWAT), despite the loss of testicular weight. Furthermore, chronic intraperitoneal administration of GnIH to male mice resulted in obesity-related glycolipid metabolic derangements, showing hyperlipidemia, hyperglycemia, glucose intolerance, and insulin resistance through changes in the expression of glucose and lipid metabolism-related genes in the pancreas and eWAT, respectively. Interestingly, the expression of GnIH and GPR147 was markedly increased in the testis of mice under conditions of energy imbalance, such as fasting, acute hypoglycemia, and hyperglycemia. In addition, chronic GnIH injection markedly inhibited glucose and lipid metabolism of mice testis while significantly decreasing testosterone synthesis and sperm quality, inducing hypogonadism. These observations indicated that orexigenic GnIH triggers hyperphagia-induced obesity-related metabolic derangements and hypogonadism in male mice, suggesting that GnIH is an emerging candidate for coupling metabolism and fertility by involvement in obesity and metabolic disorder-induced reproductive dysfunction of the testes.     

A distributed deadlock detection algorithm for mobile computing system

The mode of mobile computing originated from distributed computing and it has the un-idempotent operation property, therefore the deadlock detection algorithm designed for mobile computing systems will face challenges with regard to correctness and high efficiency. This paper attempts a fundamental study of deadlock detection for the AND model of mobile computing systems. First, the existing deadlock detection algorithms for distributed systems are classified into the resource node dependent （ RD ） and the resource node independent （RI） categories, and their corresponding weaknesses are discussed. Afterwards a new RI algorithm based on the AND model of mobile computing system is presented. The novelties of our algorithm are that： 1 ） the blocked nodes inform their predecessors and successors simultaneously; 2） the detection messages （agents） hold the predecessors information of their originator; 3 ） no agent is stored midway. Additionally, the quit-inform scheme is introduced to treat the excessive victim quitting problem raised by the overlapped cycles. By these methods the proposed algorithm can detect a cycle of size n within n - 2 steps and with （ n^2- n - 2 ）/2 agents. The performance of our algorithm is compared with the most competitive RD and RI algorithms for distributed systems on a mobile agent simulation platform. Experiment results point out that our algorithm outperforms the two algorithms under the vast majority of resource configurations and concurrent workloads. The correctness of the proposed algorithm is formally proven by the invariant verification technique.     

论高等院校改革的机遇和创造性工作

目前,山东纺织工学院正在教育改革与开放的指引下迅速发展。学院科研新立项28个;已获科研经费104.6万元;在美国匹兹堡国际博览会上,我院教师获银牌奖;许多重大科研项目转化为生产力;获国家自然科学基金项目三项;教师队伍结构迅速优化以及校办产业的迅猛发展都为学院发展展示了良好的前景。抓住机遇,深化改革和创造性工作是高校今后工作的关键。文章用现代管理学的观点从不同角度论述了高校发展的关键问题,立题新颖,颇有新意。     

Procedural Synthesis using Vortex Particle Method for Fluid Simulation

We propose a fast and effective technique to improve sub‐grid visual details of the grid based fluid simulation. Our method procedurally synthesizes the flow fields coming from the incompressible Navier‐Stokes solver and the vorticity fields generated by vortex particle method for sub‐grid turbulence. We are able to efficiently animate smoke which is highly turbulent and swirling with small scale details. Since this technique does not solve the linear system in high‐resolution grids, it can perform fluid simulation more rapidly. We can easily estimate the influence of turbulent and swirling effect to the fluid flow.     

基于业务访谈的人机交互界面设计

提出从业务访谈开始,调查人机界面交互设计的方法.从业务访谈策划、访谈中待调查的项目、展示快速原型、在迭代中前进、捕捉需求、写给开发团队等几方面阐述业务访谈中关于人机界面交互部分的具体内容.     

How argillaceous reservoirs exhibit better quality than silty mudstones?Anomalous behavior of shale gas-bearing properties of continental fine-grained sediments in Southwest China and its possible forcing mechanisms

Achieving a thorough understanding of how primary sedimentary granularity drives considerable het-erogeneity in internal reservoir attributes of terrigenous fin...     

基于免疫否定选择算法的机场航班延误状态检测与实现

把免疫算法中的否定选择算法运用到航班延误状态的诊断检测与预测中,将生物免疫系统机制与机场航班运行机制联系起来,建立了相应的自体集合、检测细胞、抗原信息及它们之间的匹配模型,给出了检测方法。首先根据机场航班运行数据生成航班检测的成熟检测器和记忆检测器,然后用否定选择算法和航班数据对检测器进行训练和改进,最后利用检测器中的信息对机场航班状态分段进行预测,获得每个时段的航班延误状况,为机场有关部门对航班延误应急处理提供决策支持。仿真实验表明,该方法能较准确地预测航班的延误状态,且实时性好。     

地电位升高对通信设备的影响及其防护

针对电力通信系统运行特点,着重对电力系统接地故障引起的地电位升高及其对通信设备的影响进行了分析,提出了相应的保护措施,并介绍了两种保护装置。     

DDCMP在电网自动化中的应用

在ＤＤＣＭＰ应用于四川省电网通信实践的基础上，对ＤＤＣＭＰ的工程技术问题进行了评估和分析。