Surveyance of disease frequency in a population by linkage to diagnostic laboratory databases. A system for monitoring the incidences of hyper- and hypothyroidism as part of the Danish iodine supplementation program

In Denmark an increase in iodine intake through salt iodization has been introduced in 1998. In parallel a program for surveyance of thyroid diseases in the population was developed as recommended by UNICEF and WHO. OBJECTIVE: To develop and evaluate a computer based system to identify and register new cases of hyper- and hypothyroidism in a well defined cohort, by linkage to diagnostic laboratory databases. DESIGN AND RESULTS: (1) Two sub cohorts for monitoring were defined (n=535,859), and evaluated to minimize loss of new cases. Collaboration was established with laboratories covering thyroid hormone analyses in the cohort; (2) a diagnostic algorithm was defined and evaluated against clinical practice; (3) evaluation of the laboratory methods employed by the four participating laboratories, to ensure they would reach the same diagnosis in a patient; (4) a register database was developed which used data imported from the laboratory databases to automatically identify previously unknown cases of hyper- and hypothyroidism and record diagnostic activity in the area. All parts of the registration were carefully evaluated. CONCLUSION: We describe for the first time a computer based system for prospective measuring the incidence rate of hyper- and hypothyroidism. The system is particularly useful for monitoring of iodine supplementation programmes.     

Multidimensional data modeling for location-based services

With the recent and continuing advances in areas such as wireless communications and positioning technologies, mobile, location-based services are becoming possible.Such services deliver location-dependent content to their users. More specifically, these services may capture the movements and requests of their users in multidimensional databases, i.e., data warehouses, and content delivery may be based on the results of complex queries on these data warehouses. Such queries aggregate detailed data in order to find useful patterns, e.g., in the interaction of a particular user with the services.The application of multidimensional technology in this context poses a range of new challenges. The specific challenge addressed here concerns the provision of an appropriate multidimensional data model. In particular, the paper extends an existing multidimensional data model and algebraic query language to accommodate spatial values that exhibit partial containment relationships instead of the total containment relationships normally assumed in multidimensional data models. Partial containment introduces imprecision in aggregation paths. The paper proposes a method for evaluating the imprecision of such paths. The paper also offers transformations of dimension hierarchies with partial containment relationships to simple hierarchies, to which existing precomputation techniques are applicable.Received: 28 September 2002, Accepted: 5 April 2003, Published online: 12 August 2003Edited by: J. Veijalainen Correspondence to: I. Timko     

Learning Paths to Offshore Outsourcing: From Cost Reduction to Knowledge Seeking

A corporation's offshore outsourcing may be seen as the result of a discrete, strategic decision taken in response to an increasing pressure from worldwide competition. However, empirical evidence of a representative cross-sector sample of international Danish firms indicates that offshore sourcing in low-cost countries is best described as a learning-by-doing process in which the offshore outsourcing of a corporation goes through a sequence of stages towards sourcing for innovation. Initially, a corporation's outsourcing is driven by a desire for cost minimization. Over a period of time the outsourcing experience lessens the cognitive limitations of decision-makers as to the advantages that can be achieved through outsourcing in low-cost countries: the insourcer/vendor may not only offer cost advantages, but also quality improvement and innovation. The quality improvements that offshore outsourcing may bring about evoke a realization in the corporation that even innovative processes can be outsourced.     

Replacing the ({beta}{alpha})-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme

In order to investigate how structural modifications interferewith protein stability, we modified a (ß)-unit inE.coli triosephosphate isomerase (TIM), a typical (ß)-barrelprotein, assuming that the pseudosymmetrical ß-barrelcan be divided into eight successive loop/ß-strand/loop/-helixmotifs. We replaced the eighth (ß)-unit of E.coliTIM with the corresponding chicken (ß)-unit. The substitution,involving the replacement of 10 of the 23 residues of this (ß)-unit, was evaluated first by modelling, then experimentally.Modelling by bomology suggests how the amino add replacementsmight be accommodated in the hybrid E.coli/chicken TIM (ETCM8CHI).Both natural and hybrid recombinant TIMs, overproduced in E.coli,were purified to homogeneity and characterized as to their stabilityand kinetics. Our kinetic studies show that the modificationperformed here leads to an active enzyme. The stability studiesindicate that the stability of ETIM8CHI is comparable to thatof the wild type TIM.     

Trimming of Graphs, with Application to Point Labeling

For t>0 and g≥0, a vertex-weighted graph of total weight W is (t,g)-trimmable if it contains a vertex-induced subgraph of total weight at least (1−1/t)W and with no simple path of more than g edges. A family of graphs is trimmable if for every constant t>0, there is a constant g≥0 such that every vertex-weighted graph in the family is (t,g)-trimmable. We show that every family of graphs of bounded domino treewidth is trimmable. This implies that every family of graphs of bounded degree is trimmable if the graphs in the family have bounded treewidth or are planar. We also show that every family of directed graphs of bounded layer bandwidth (a less restrictive condition than bounded directed bandwidth) is trimmable. As an application of these results, we derive polynomial-time approximation schemes for various forms of the problem of labeling a subset of given weighted point features with nonoverlapping sliding axes-parallel rectangular labels so as to maximize the total weight of the labeled features, provided that the ratios of label heights or the ratios of label lengths are bounded by a constant. This settles one of the last major open questions in the theory of map labeling.     

Determination of volterra transfer functions of non-linear multiport networks

A method is presented to determine frequency domain Volterra transfer functions of non-linear multiport networks containing non-linear multiport subsystems (elements). the method is based on an extension of the probing method to allow arbitrary (also commensurate) frequencies. A recursively based algorithm for the determination of Volterra transfer functions of non-linear multiport networks is derived. A computer implementation of the method in a symbolic programming language is presented. This makes it possible to determine algebraic expressions of the Volterra transfer functions. Three examples are considered.     

Raft crystals of poly(isoprene)-block-poly(ferrocenyldimethylsilane) and their surface wetting behavior during melting as observed by AFM and NanoTA

We report on the morphology evolution during heating and melting of lamellar poly(isoprene)-block-poly(ferrocenyldimethylsilane) (PI₇₆-b-PFDMS₇₆) raft crystals deposited at the native oxide surface of silicon (SiO₂) or at a highly ordered pyrolytic graphite (HOPG) surface, studied by in situ temperature controlled atomic force microscopy. Crystals deposited on hydrophilic SiO₂ surfaces revealed an irreversible decrease in length at temperatures of up to tens of degrees above their expected melting temperature, while maintaining their platelet-like structure. Crystals deposited on hydrophobic HOPG surfaces initially decreased in length below their expected melting temperature, while at 120 °C and above a typical molten morphology was observed. In addition, the irreversible formation of a PI₇₆-b-PFDMS₇₆ wetting layer around the crystals was observed upon increasing the temperature. These observations in the morphological behavior upon heating emphasize the role of interfacial energy between a surface deposited block copolymer based macromolecular nanostructure and its supporting substrate.     

Specifying OLAP Cubes on XML Data

On-Line Analytical Processing (OLAP) enables analysts to gain insight about data through fast and interactive access to a variety of possible views on information, organized in a dimensional model. The demand for data integration is rapidly becoming larger as more and more information sources appear in modern enterprises. In the data warehousing approach, selected information is extracted in advance and stored in a repository, yielding good query performance. However, in many situations a logical (rather than physical) integration of data is preferable. Previous web-based data integration efforts have focused almost exclusively on the logical level of data models, creating a need for techniques focused on the conceptual level. Also, previous integration techniques for web-based data have not addressed the special needs of OLAP tools such as handling dimensions with hierarchies. Extensible Markup Language (XML) is fast becoming the new standard for data representation and exchange on the World Wide Web. The rapid emergence of XML data on the web, e.g., business-to-business (B2B) e-commerce, is making it necessary for OLAP and other data analysis tools to handle XML data as well as traditional data formats.Based on a real-world case study, this paper presents an approach to specification of OLAP DBs based on web data. Unlike previous work, this approach takes special OLAP issues such as dimension hierarchies and correct aggregation of data into account. Also, the approach works on the conceptual level, using Unified Modeling Language (UML) as a basis for so-called UML snowflake diagrams that precisely capture the multidimensional structure of the data. An integration architecture that allows the logical integration of XML and relational data sources for use by OLAP tools is also presented.     

DCB-specimen loaded with uneven bending moments

A double cantilever beam specimen loaded with uneven bending moments (DCB-UBM) is proposed for mixed mode fracture mechanics characterisation of adhesive joints, laminates and multilayers. A linear elastic fracture mechanics analysis gives the energy release rate and mode mixity analytically for both isotropic and orthotropic materials. By varying the ratio between the two applied moments, the crack tip stress state can be varied from pure mode I to pure mode II for the same specimen geometry. The specimen allows stable crack growth. A special test fixture is developed to create uneven bending moments. As a preliminary example, the DCB-UBM specimen was used for characterising fracture of adhesive joints between two laminates of thermoset glass fibre reinforced plastic.