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排序方式: 共有1203条查询结果,搜索用时 484 毫秒
41.
Dr. Masanobu Nagano Takumi Oguro Ryo Sawada Dr. Toru Yoshitomi Prof. Keitaro Yoshimoto 《Chembiochem : a European journal of chemical biology》2021,22(23):3341-3347
Dysregulation of tumor necrosis factor-α (TNFα), a pro-inflammatory cytokine, causes several diseases, making it an important therapeutic target. Here, we identified a novel DNA aptamer against human TNFα using in vitro selection, which included a high exclusion pressure process against non-binding and weak binders through microbead-assisted capillary electrophoresis (MACE) in only three rounds. Among the 15 most enriched aptamers, Apt14 exhibited the highest inhibitory activity for the interaction between TNFα and its cognate receptor in mouse L929 cells. For further improving the bioactivity of the aptamer, dimerization programed by hybridization was evaluated, resulting in the Apt14 dimer exhibited a twofold higher binding affinity and stronger inhibition compared to the monomer counterpart. Rapid identification of bioactive aptamers using MACE in combination with facile dimerization by hybridization accelerates the discovery of novel bioactive aptamers, paving the way toward replacing current monoclonal antibody therapy with the less expensive and non-immunogenic aptamer therapy. 相似文献
42.
Adhesion between polymer surface modified by graft polymerization and tissue during surgery using an ultrasonically activated scalpel device
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Kwangwoo Nam Takuya Iwata Tsuyoshi Kimura Hiroki Ikake Shigeru Shimizu Toru Masuzawa Akio Kishida 《应用聚合物科学杂志》2014,131(20)
In the field of surgery, achieving adhesion between a polymer implant and tissue poses a challenge considering that suturing is not appropriate for the stability of such implants. An ultrasonically activated scalpel that generates heat by mechanical vibration and promotes adhesion between a polymer implant and native tissue by pressing the two materials together has very good potential for application in the field. To determine the type of polymer that is suitable for the purpose, we investigated polyethylene (PE) and polystyrene (PS) films, the surfaces of which were activated by corona discharge. Graft polymerization was then performed on the corona‐treated surfaces to vary their properties. The corona‐treated PE and PS films grafted with poly(acrylic acid), poly(methacrylic acid), poly(vinyl benzylacrylic acid), and poly(hydroxylethyl acrylate), respectively, adhered to the tissue when the ultrasonically activated scalpel was applied. The heat generated by the mechanical vibration and the applied pressure enabled the carboxyl or hydroxyl groups to bond with the proteins in the extracellular matrix. We therefore concluded that it was possible to integrate this technique in the development of new types of polymer devices that could be stably implanted in a living body. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40885. 相似文献
43.
To develop a simple and effective process for upgrading low-grade titanium ore (ilmenite, mainly FeTiO3), a new selective chlorination process based on the use of calcium chloride (CaCl2) as the chlorine source was investigated in this study. Titanium ore and a titanium ore/CaCl2 mixture were placed in two separate crucibles inside a gas-tight quartz tube that was then positioned in a horizontal furnace. In the experiments, the titanium ore in the two crucibles reacted with either HCl produced from CaCl2 or CaCl2 itself at 1100 K (827 °C), leading to the selective removal of the iron present in the titanium ore as iron chlorides [FeCl x (l,g) (x = 2, 3)]. Various kinds of titanium ores produced in different countries were used as feedstock, and the influence of the particle size and atmosphere on the selective chlorination was investigated. Under certain conditions, titanium dioxide (TiO2) with purity of about 97 pct was directly obtained in a single step from titanium ore containing 51 pct TiO2. Thus, selective chlorination is a feasible method for producing high purity titanium dioxide from low-grade titanium ore. 相似文献
44.
Haruto Kumura Megumi Satoh Taiki Machiya Makoto Hosono Toru Hayakawa Jun‐ichi Wakamatsu 《International Journal of Dairy Technology》2019,72(3):403-408
The lipolytic and proteolytic activity of Penicillium camemberti PC TT033 and Penicillium roqueforti PR G3, cultured on the whey solids or simulated cheese media, were compared under several pH reaction conditions. Lipolytic activity was higher when both strains had been cultured on the whey medium than on the simulated cheese medium, whereas proteolytic activity was less influenced by the culture medium. The relationship between the reaction pH and these enzyme activities was dependent on the culture medium, which suggested that the expression level and balance of isozyme rely on the culture substrate. 相似文献
45.
Toru Moriyama Jun-ichi Mashiko Toshinori Matsui Koichiro Enomoto Tetsuya Matsui Kojiro Iizuka Masashi Toda Yukio Pegio Gunji 《Artificial Life and Robotics》2016,21(3):247-252
The soldier crab appears in great numbers and feeds while wandering during daytime low tide. When they see an approaching object, they screw themselves into the sand. The mechanism of formation of mass wandering has not been clarified. In this study, to investigate if the soldier crabs use visual images of neighbors as a stimulus for wandering, dummy crabs were presented to crabs. In the experiments, one, two, four, or eight dummies were placed in a circle on a sand arena. Each crab was placed in the center of the arena and observed whether it burrowed into the sand or wandered. The proportions of wandering individuals in each experimental treatment were compared with the expected value. Significantly more crabs were wanderers when only two and four dummies were present. This result suggests that soldier crabs chose burrowing or wandering depending on visual image of the distribution of the neighbors. 相似文献
46.
47.
The thermally assisted machining of yttria-stabilized tetragonal zirconia polycrystal using a cutting tool heated with induction heating was proposed. Although the conventional thermally assisted machining cannot be applied to drilling, the proposed method can be. Heat transfer from the heated cutting tool to the workpiece was simulated analytically, and the result showed that heating of the tool up to 500 °C produced an increase of 150–400 °C in the workpiece temperature. Cutting experiments demonstrated an improvement in machinability. 相似文献
48.
Kenji Iwase Kazuhiro Mori Akinori Hoshikawa Toru Ishigaki 《International Journal of Hydrogen Energy》2012
The crystal structure and hydrogenation properties of Ce2Ni7-type Gd2Ni7 were investigated by X-ray diffraction (XRD) and the hydrogen pressure–composition (P–C) isotherm. Ce2Ni7-type Gd2Ni7 was obtained by annealing at 1523 K for 12 h and quenching in ice water. Two superlattice reflections (002 and 004) of the Ce2Ni7-type were clearly observed at 2θ = 7.3° and 14.6° in the XRD profile. The refined lattice parameters were a = 0.49662(9) nm and c = 2.4255(3) nm, respectively. Two plateaus were clearly observed during the absorption–desorption process in the P–C isotherm. The first and second plateaus were at 0.015 and 0.13 MPa, respectively, in the first desorption. The maximum hydrogen capacity reached was 1.13 H/M. The enthalpy and entropy were calculated as −20 kJ/mol H2 and −80 J/mol H2 K, respectively, from the van’t Hoff plot. After the P–C isotherm, the GdNi5 cell expanded by 2.15%, but the Gd2Ni4 cell shrank by 2.83%. 相似文献
49.
Yoshimitsu Sagara Toru Komatsu Tasuku Ueno Kenjiro Hanaoka Takashi Kato Tetsuo Nagano 《Advanced functional materials》2013,23(42):5277-5284
Switching of the luminescence properties of molecular materials in response to mechanical stimulation is of fundamental interest and also has a range of potential applications. Herein, a water‐soluble mechanochromic luminescent pyrene derivative having two hydrophilic dendrons is reported. This pyrene derivative is the first example of a mechanochromic luminescent organic compound that responds to relative humidity. Mechanical stimulation (grinding) of this pyrene derivative in the solid state results in a change of the photoluminescence from yellow to green. Subsequent exposure to water vapor induces recovery of the initial yellow photoluminescence. The color change is reversible through at least ten cycles. It is also demonstrated that this compound can be applied as a mechano‐sensing material in frictional wear testing for grease, owing to its immiscibility in non‐polar solvents and its non‐crystalline behavior. Transmission electron microscope and atomic force microscope observations of samples prepared from dilute aqueous solutions of the pyrene derivative on suitable substrates, together with dynamic light scattering measurements for the compound in aqueous solution, indicate that this amphiphilic dumbbell‐shaped molecule forms micelles in water. 相似文献
50.
Ryota Miyata Toru Aonishi Jun Tsuzurugi Koji Kurata 《Artificial Life and Robotics》2012,17(1):163-167
In this paper, we investigate the effect of synaptogenesis on memories in the brain, using the abstract-associative memory model, Hopfield model with the zero-order synaptic decay. Using the numerical simulation, we demonstrate the possibility that synaptogenesis plays a role in maintaining recent memories embedded in the network while avoiding overloading. For the network consisting of 1000 units, it turned out that the minimum decay rate to avoid overloading is 0.02, and the optimal decay rate to maximize the storage capacity is 0.08. We also show that the average numbers of replacement synapses at each learning step corresponding to these two values are 1187 and 21024, respectively. 相似文献