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排序方式: 共有322条查询结果,搜索用时 31 毫秒
1.
MA Steller KJ Gurski M Murakami RW Daniel KV Shah E Celis A Sette EL Trimble RC Park FM Marincola 《Canadian Metallurgical Quarterly》1998,4(9):2103-2109
Human papillomavirus (HPV) infection has been causally associated with cervical cancer. We tested the effectiveness of an HLA-A*0201-restricted, HPV-16 E7 lipopeptide vaccine in eliciting cellular immune responses in vivo in women with refractory cervical cancer. In a nonrandomized Phase I clinical trial, 12 women expressing the HLA-A2 allele with refractory cervical or vaginal cancer were vaccinated with four E786-93 lipopeptide inoculations at 3-week intervals. HLA-A2 subtyping was also performed, and HPV typing was assessed on tumor specimens. Induction of epitope-specific CD8+ T-lymphocyte (CTL) responses was analyzed using peripheral blood leukapheresis specimens obtained before and after vaccination. CTL specificity was measured by IFN-gamma release assay using HLA-A*0201 matched target cells. Clinical responses were assessed by physical examination and radiographic images. All HLA-A*0201 patients were able to mount a cellular immune response to a control peptide. E786-93-specific CTLs were elicited in 4 of 10 evaluable HLA-A*0201 subjects before vaccination, 5 of 7 evaluable HLA-A*0201 patients after two vaccinations, and 2 of 3 evaluable HLA-A*0201 cultures after all four inoculations. Two of three evaluable patients' CTLs converted from unreactive to reactive after administration of all four inoculations. There were no clinical responses or treatment toxicities. The ability to generate specific cellular immune responses is retained in patients with advanced cervical cancer. Vaccination with a lipidated HPV peptide epitope appears capable of safely augmenting CTL reactivity. Although enhancements of cellular immune responses are needed to achieve therapeutic utility in advanced cervical cancer, this approach might prove useful in treating preinvasive disease. 相似文献
2.
Abstract— Recent commercial liquid‐crystal‐display (LCD) televisions are larger and brighter than traditional televisions, thus impacting the viewing conditions in which they are viewed. These changes in viewing conditions may require different electro‐optical transfer functions (EOTFs) for LCD TVs than those for conventional TVs. Here, the way various EOTFs affect the preferred image quality of test images with changes in brightness and surround illumination conditions are examined. The first method used a gain, offset, and gamma (GOG) function with a range of gamma values, and the second method altered the intrinsic EOTFs. Image preference for the simulated EOTFs was determined using a paired‐comparison experiment for ten images. The first experiment took place in a darkened room at two display luminance levels. The results indicated that a gamma of 1.6 was most preferred overall although more so at a lower screen luminance level. In a second experiment, the procedure was repeated with a dim surround of 10% of the display's white point. With this surround, preference for a gamma value of around 1.6 at both screen luminance levels was more enhanced. These results indicated that image preference for different EOTFs is dependent on display luminance and that this dependence is maintained with a dim surround. 相似文献
3.
Y Sun A Hildesheim LA Brinton PC Nasca CL Trimble RJ Kurman RP Viscidi KV Shah 《Canadian Metallurgical Quarterly》1996,63(2):200-203
We describe a case of positional dyspnea due to compression of the tracheobronchial tree by an extensive thoracic aneurysm. In a 77-year-old woman with long-standing systemic hypertension, intermittent anterior chest pain gradually developed over several years. She had no history of asthma or thoracic trauma. She was admitted to our hospital because of sudden, severe shortness of breath. The breathlessness was markedly worse when she lay on her back or on her right side. On physical examination, she was in acute respiratory distress with cyanosis, severe hypertension (180/110 mmHg), tachycardia, and inspiratory stridor. A chest X-ray film showed loss of volume and nearly complete radiopacity of the left hemithorax. Arterial blood gas analysis revealed an arterial oxygen partial pressure of 54.8 mmHg, a carbon dioxide partial pressure of 39.8 mmHg, and an oxygen saturation of 84.5 percent on room air. Computed tomographic examination of the thorax showed dilation of the aortic arch and descending aorta, and marked compression of the trachea and the left main bronchus. Examination with a fiberoptic bronchoscope revealed extrinsic compression of the trachea just proximal to the carina. The patient's symptoms stabilized. However, she did not undergo surgery because of her age and because of the size of the aneurysm. She died due to rupture of the aneurysm. 相似文献
4.
Sørland Kaia Ingerdatter Sunoqrot Mohammed R. S. Sandsmark Elise Langørgen Sverre Bertilsson Helena Trimble Christopher G. Lin Gigin Selnæs Kirsten M. Goa Pål E. Bathen Tone F. Elschot Mattijs 《Magma (New York, N.Y.)》2022,35(4):573-585
Magnetic Resonance Materials in Physics, Biology and Medicine - Signal intensity normalization is necessary to reduce heterogeneity in T2-weighted (T2W) magnetic resonance imaging (MRI) for... 相似文献
5.
R1-soar: an experiment in knowledge-intensive programming in a problem-solving architecture 总被引:2,自引:0,他引:2
Rosenbloom PS Laird JE McDermott J Newell A Orciuch E 《IEEE transactions on pattern analysis and machine intelligence》1985,(5):561-569
This paper presents an experiment in knowledge-intensive programming within a general problem-solving production-system architecture called Soar. In Soar, knowledge is encoded within a set of problem spaces, which yields a system capable of reasoning from first principles. Expertise consists of additional rules that guide complex problem-space searches and substitute for expensive problem-space operators. The resulting system uses both knowledge and search when relevant. Expertise knowledge is acquired either by having it programmed, or by a chunking mechanism that automatically learns new rules reflecting the results implicit in the knowledge of the problem spaces. The approach is demonstrated on the computer-system configuration task, the task performed by the expert system R1. 相似文献
6.
Tests of random, alternating cuts on a ball-model of in Al–Cu alloy have been run to check the kinetics at which disordering occurs in an initially ordered precipitate subject to cyclic strain. In addition, fatigue tests at low temperature (78 K) and various microscopical observations have been made on Al–Ag alloy containing GP zones to check whether a structure containing an initially disordered precipitate will cyclically soften or not. It was thus found that the ball model disorders as a function of accumulated plastic strain consistently with the kinetics of cyclic softening in actual material. Further, Al–Ag alloy was found not to soften at 78 K. Both of these results supoort the disordering hypothesis of cyclic softening over the dissolution or shearing-off mechanisms, although other systems may be subject to these mechanisms. In spite of the low temperature at which the Al–Ag alloy was tested, small / precipitates were found to have formed in the longest lived test; however, this result did not interfere with the validity of the experiment as it did previously at room temperature. The fatigue lives at 78 K were much longer than those previously measured at room temperature although the failure mechanisms were not affected at high strain and only somewhat affected at low strain (there was increased incidence of transgranular crack nucleation and propagation).
Résumé Des essais d'application de coups alternés et aléatoires sur un modèle de simulation par des billes de la phase dans les alliages de Cu–Al ont été effectués en vue de vérifier la cinétique suivant laquelle se produisent des désordres dans un précipité initialement ordonné et soumis à des déformations cycliques. En outre, des essais de fatigue à basse température (78°K) ainsi que diverses observations microscopiques ont été effectués sur un alliage Al–Ag comportant des zones GP en vue de vérifier si une structure comportant un précipité initialement en désordre subirait un adoucissement cyclique ou non. On a donc trouvé que le modèle de utilisant des billes fait état de désordres en fonction de l'accumulation de la déformation plastique et ce en rapport avec la cinétique d'adoucissement cyclique dans le matériau réel. En outre, l'alliage Al–Ag s'est révélé ne pas s'adoucir à 78°K. Ces deux résultats soutiennent l'hypothèse suivant laquelle un adoucissement cyclique s'accompagne de désordres plutôt que de mécanismes de disolution ou de séparation par cisaillement, bien que d'autres systèmes puissent être sujets à ces mécanismes. En dépit de la basse température à laquelle l'alliage Al–Ag a été essayé, on a trouvé de petits précipités / qui se sont formés au cours des essais, les plus longs. Cependant, ce résultat ne gène pas la validité de l'expérience comme c'était le cas précédemment à température ambiante. Les vies en fatigue à 78°K ont été trouvées bien plus longues que celles mesurées précédemment à température ambiante, en dépit du fait que le mécanisme de rupture n'ait pas été affecté sous les déformations élevées et ne l'a été que quelque peu sous les déformations faibles, auxquelles apparait une incidence croissante d'une nucléation et d'une propagation d'une fissure transgranulaire.相似文献
7.
John E. Laird Douglas J. Pearson Scott B. Huffman 《Journal of Intelligent Information Systems》1997,9(3):261-275
Most work on adaptive agents have a simple, single layerarchitecture. However, most agent architectures support three levels ofknowledge and control: a reflex level for reactive responses, a deliberatelevel for goal-driven behavior, and a reflective layer for deliberateplanning and problem decomposition. In this paper we explore agentsimplemented in Soar that behave and learn at the deliberate and reflectivelevels. These levels enhance not only behavior, but also adaptation. Theagents use a combination of analytic and empirical learning, drawing from avariety of sources of knowledge to adapt to their environment. We hypothesize that complete, adaptive agents must be able to learn across all three levels. 相似文献
8.
Force measurement in friction stir welding (FSW) provides a significant insight into the process in terms of machine and tool limitations and design. In the present research the tool forces were investigated experimentally using a rotating component dynamometer and through the development of a finite element model. The model correlated well with experimental temperatures and tool forces and was capable of predicting tool forces for different welding parameters, predicting regions were tool failure is likely to occur and identifying tool pin designs which can process the workpiece more efficiently. 相似文献
9.
R.J. Allwood M.R. Shaw J.L. Smith D.J. Stewart E.G. Trimble 《Building Research & Information》2013,41(1):37-42
In our January/February issue last year, Jim Smith described the insights he had gained as the human expert being ‘mined’ by the knowledge engineers for an expert system to aid diagnosis of the causes of dampness in buildings. An overview of that BREDAMP project is presented here, explaining the background to the project and its objectives, and the way the expert system was created, discussing in detail the methods used to capture the depth of knowledge available. 相似文献
10.
Ritesh Tipnis Jan Bernkopf Shijun Jia John Krieg Sergey Li Mark Storch Darin Laird 《Solar Energy Materials & Solar Cells》2009,93(4):442-446
Here we describe the fabrication of the largest (233 cm2 total area) organic photovoltaic (OPV) module (polymer:fullerene) to be certified by the National Renewable Energy Laboratory (NREL). OPV solar cells were fabricated at Plextronics by spin coating a blend of poly 3-hexylthiophene-2,5 diyl (P3HT) and [6,6] phenyl C61 butyric acid methyl ester (PCBM) on top of our hole transport layer (HTL), Plexcore® OC. In laboratory-scale devices (0.09 cm2), this system routinely exhibits power conversion efficiencies exceeding 3.7%. This P3HT:PCBM active layer and HTL ink system was used to scale up to the larger area module (15.2 cm×15.2 cm module size, i.e. 233 cm2 total area; 108 cm2 active area), which was certified by NREL as having 1.1% total area efficiency (3.4% active area efficiency). 相似文献