Jet-grouting

An ultra-high pressure jet of water and air with simultaneous cement grouting is revolutionishing the practice of ground consolidation and foundation reinforcement. Swedish research has been studying this development, briefly explained here. The note report is based on a summary note issued by the Swedish Council for Building Research.     

Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer—Are They Genetically Different?

Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investigate prostate cancer heterogeneity, the genetic profiles of multifocal and unifocal prostate cancers were compared. Here, we report observations deduced from tumor-tumor comparison of copy number alteration data of both focal categories. Forty-one fresh frozen prostate cancer foci from 14 multifocal prostate cancers and eight unifocal prostate cancers were subjected to copy number variation analysis with the Affymetrix SNP 6.0 microarray tool. With the investigated cases, tumors obtained from a single prostate exhibited different genetic profiles of variable degrees. Further comparison identified no distinct genetic pattern or signatures specific to multifocal or unifocal prostate cancer. Our findings suggest that samples obtained from multiple sites of a single unifocal prostate cancer show as much genetic heterogeneity and variability as separate tumors obtained from a single multifocal prostate cancer.     

Relationship between structure and electroluminescence of oligo(p-phenylenevinylene)s

The preparation of LEDs with poly( p-phenylenevinylene) (PPV) as emitting material is well established. However, due to the presence of a distribution of conjugated chain lengths in the polymer, systematic investigations of the electroluminescence with polymeric materials are difficult, as far as the optical emission is concerned. We are studying the relationship between structural variation of substituted oligo(p-phenylenevinylene)s and their electroluminescent behaviour using a series of distyrylbenzenes with a variety of substituents in order to investigate their influence on the electroluminescence (EL). Furthermore, we synthesized a homologous series of monodisperse oligo(2,5-dipropoxy-1,4-phenylenevinylene)s with up to 11 repeating units. This series covers the spectrum from monomer to polymer. The influence on the EL can be investigated by preparing single layer LEDs using vapor deposition or spincoating of the oligomers in a polystyrene (PS) matrix. The comparison of photoluminescence (PL)- and EL-spectra shows that the photophysical properties of the oligomers are strongly altered by aggregation phenomena.     

Low-temperature properties of styrene–butadiene–styrene polymer modified bitumens

Low-temperature properties of the modified bitumens containing styrene–butadiene–styrene (SBS) polymers were investigated using conventional methods, dynamic mechanical analysis (DMA) and bending beam rheometer (BBR). Effects of the characteristics of base bitumens and polymers and the proportion of the components on these properties were studied. The results indicated that SBS polymers improved low-temperature properties of bitumens. The degree of improvement generally increased with SBS content and were influenced slightly by SBS structure. The study also showed a statistically linear relationships between different low-temperature parameters.     

Characterization of isotopic abundance measurements in high resolution FT-ICR and Orbitrap mass spectra for improved confidence of metabolite identification

Currently there is limited information available on the accuracy and precision of relative isotopic abundance (RIA) measurements using high-resolution direct-infusion mass spectrometry (HR DIMS), and it is unclear if this information can benefit automated peak annotation in metabolomics. Here we characterize the accuracy of RIA measurements on the Thermo LTQ FT Ultra (resolution of 100,000-750,000) and LTQ Orbitrap (R = 100,000) mass spectrometers. This first involved reoptimizing the SIM-stitching method (Southam, A. D. Anal. Chem. 2007, 79, 4595-4602) for the LTQ FT Ultra, which achieved a ca. 3-fold sensitivity increase compared to the original method while maintaining a root-mean-squared mass error of 0.16 ppm. Using this method, we show the quality of RIA measurements is highly dependent on signal-to-noise ratio (SNR), with RIA accuracy increasing with higher SNR. Furthermore, a negative offset between the theoretical and empirically calculated numbers of carbon atoms was observed for both mass spectrometers. Increasing the resolution of the LTQ FT Ultra lowered both the sensitivity and the quality of RIA measurements. Overall, although the errors in the empirically calculated number of carbons can be large (e.g., 10 carbons), we demonstrate that RIA measurements do improve automated peak annotation, increasing the number of single empirical formula assignments by >3-fold compared to using accurate mass alone.     

Hybrid time domain solvers for the Maxwell equations in 2D

We present a new approach to time domain hybrid schemes for the Maxwell equations. By combining the classical FD‐TD scheme with two unstructured solvers, one explicit finite volume solver and one implicit finite element solver, we achieve a very efficient and flexible second‐order scheme. The second‐order accuracy of the hybrid scheme is verified through convergence studies on perfectly conducting as well as dielectric and diamagnetic circular cylinders. The numerical results also show its superiority to the FD‐TD scheme. Copyright © 2002 John Wiley & Sons, Ltd.     

Surface roughness measurement on machined surfaces using angular speckle correlation

Surface roughness is of great importance in fields, such as tribology, semiconductor technology and medicine. Stylus techniques, in which a stylus is drawn along the surface and the vertical movement of the stylus is recorded, have been used traditionally in measuring surface roughness. Non-contact methods, such as optical ones, have the advantage that they can be used for the in-process measurement of surface roughness. In this paper, results of the measurement of surface roughness using angular speckle-correlation on machined surfaces are presented. Surfaces of approximately 1.6 < R_a < 6.3 μm have been measured, the surfaces being classified in the same manner as when using a stylus instrument. ASC is a technique that also allows in-process measurement of the roughness of surfaces on machined surfaces. A new technique to achieve increased repeatability by using an angle detection unit is also presented in this paper.