A multi-method, holistic strategy for researching critical success factors in IT projects

In the field of information systems (IS) there is an observable trend towards the use of multi-method research. Using different research methods allows for the cross-validation of data obtained via multiple approaches, with the potential to increase the robustness of research results. Such a multi-method approach is applicable to a comprehensive research agenda on critical success factors, an agenda that needs to take into account not only the identification, but also the analysis and management of critical success factors. The goal of this article is to contribute new knowledge on how to carry out research on critical success factors in IS projects using a multi-method approach. For this purpose, two research projects are presented, each a variation of the research design customized to particular circumstances. First, there is an outline of the research approach taken for a critical success factor research project in the field of portal implementation, with discussion of the strengths and weaknesses of the project. Taking into consideration these experiences, the research approach of a similar critical success factor research project in the field of offshore software development is then described. Finally, recommendations for using the multi-method research approach in critical success factor research are presented.     

MNPBEM – A Matlab toolbox for the simulation of plasmonic nanoparticles

MNPBEM is a Matlab toolbox for the simulation of metallic nanoparticles (MNP), using a boundary element method (BEM) approach. The main purpose of the toolbox is to solve Maxwell?s equations for a dielectric environment where bodies with homogeneous and isotropic dielectric functions are separated by abrupt interfaces. Although the approach is in principle suited for arbitrary body sizes and photon energies, it is tested (and probably works best) for metallic nanoparticles with sizes ranging from a few to a few hundreds of nanometers, and for frequencies in the optical and near-infrared regime. The toolbox has been implemented with Matlab classes. These classes can be easily combined, which has the advantage that one can adapt the simulation programs flexibly for various applications.Program summaryProgram title: MNPBEMCatalogue identifier: AEKJ_v1_0Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEKJ_v1_0.htmlProgram obtainable from: CPC Program Library, Queen?s University, Belfast, N. IrelandLicensing provisions: GNU General Public License v2No. of lines in distributed program, including test data, etc.: 15 700No. of bytes in distributed program, including test data, etc.: 891 417Distribution format: tar.gzProgramming language: Matlab 7.11.0 (R2010b)Computer: Any which supports Matlab 7.11.0 (R2010b)Operating system: Any which supports Matlab 7.11.0 (R2010b)RAM: ?1 GByteClassification: 18Nature of problem: Solve Maxwell?s equations for dielectric particles with homogeneous dielectric functions separated by abrupt interfaces.Solution method: Boundary element method using electromagnetic potentials.Running time: Depending on surface discretization between seconds and hours.     

Geometric calibration of head-mounted displays and its effects on distance estimation

Head-mounted displays (HMDs) allow users to observe virtual environments (VEs) from an egocentric perspective. However, several experiments have provided evidence that egocentric distances are perceived as compressed in VEs relative to the real world. Recent experiments suggest that the virtual view frustum set for rendering the VE has an essential impact on the user's estimation of distances. In this article we analyze if distance estimation can be improved by calibrating the view frustum for a given HMD and user. Unfortunately, in an immersive virtual reality (VR) environment, a full per user calibration is not trivial and manual per user adjustment often leads to mini- or magnification of the scene. Therefore, we propose a novel per user calibration approach with optical see-through displays commonly used in augmented reality (AR). This calibration takes advantage of a geometric scheme based on 2D point - 3D line correspondences, which can be used intuitively by inexperienced users and requires less than a minute to complete. The required user interaction is based on taking aim at a distant target marker with a close marker, which ensures non-planar measurements covering a large area of the interaction space while also reducing the number of required measurements to five. We found the tendency that a calibrated view frustum reduced the average distance underestimation of users in an immersive VR environment, but even the correctly calibrated view frustum could not entirely compensate for the distance underestimation effects.     

Melt Crystallization of Ammonium Dinitramide (ADN) Investigated by Means of X-ray Diffraction

Ammonium dinitramide (ADN) is a promising oxidizing agent for solid rocket propellants. In situ XRD investigations of ADN and ADN suspensions have been performed in order to understand and refine the emulsion crystallization process for manufacturing spherical ADN particles (prills). The investigation revealed that the melt crystallization behavior depends on ADN quality, humidity, maximum temperature of temperature cycles, and suspension agents. Further investigations will focus on additives for controlling the mechanisms investigated, e.g., by seeding.     

Personalized Development of Antisense Oligonucleotides for Exon Skipping Restores Type XVII Collagen Expression in Junctional Epidermolysis Bullosa

Intermediate junctional epidermolysis bullosa caused by mutations in the COL17A1 gene is characterized by the frequent development of blisters and erosions on the skin and mucous membranes. The rarity of the disease and the heterogeneity of the underlying mutations renders therapy developments challenging. However, the high number of short in-frame exons facilitates the use of antisense oligonucleotides (AON) to restore collagen 17 (C17) expression by inducing exon skipping. In a personalized approach, we designed and tested three AONs in combination with a cationic liposomal carrier for their ability to induce skipping of COL17A1 exon 7 in 2D culture and in 3D skin equivalents. We show that AON-induced exon skipping excludes the targeted exon from pre-mRNA processing, which restores the reading frame, leading to the expression of a slightly truncated protein. Furthermore, the expression and correct deposition of C17 at the dermal–epidermal junction indicates its functionality. Thus, we assume AON-mediated exon skipping to be a promising tool for the treatment of junctional epidermolysis bullosa, particularly applicable in a personalized manner for rare genotypes.     

Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic of Metabolic Syndrome and Premature Coronary Heart Disease—Family Study

HDL particles can be structurally modified in atherosclerotic disorders associated with low HDL cholesterol level (HDL-C). We studied whether the lipidome of the main phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelin (SM) species of HDL2 and HDL3 subfractions is associated with premature coronary heart disease (CHD) or metabolic syndrome (MetS) in families where common low HDL-C predisposes to premature CHD. The lipidome was analyzed by LC-MS. Lysophosphatidylcholines were depleted of linoleic acid relative to more saturated and shorter-chained acids containing species in MetS compared with non-affected subjects: the ratio of palmitic to linoleic acid was elevated by more than 30%. A minor PC (16:0/16:1) was elevated (28–40%) in MetS. The contents of oleic acid containing PCs were elevated relative to linoleic acid containing PCs in MetS; the ratio of PC (16:0/18:1) to PC (16:0/18:2) was elevated by 11–16%. Certain PC and SM ratios, e.g., PC (18:0/20:3) to PC (16:0/18:2) and a minor SM 36:2 to an abundant SM 34:1, were higher (11–36%) in MetS and CHD. The fatty acid composition of certain LPCs and PCs displayed a characteristic pattern in MetS, enriched with palmitic, palmitoleic or oleic acids relative to linoleic acid. Certain PC and SM ratios related consistently to CHD and MetS.