Synthesis of Autosymmetric Functions in a New Three-Level Form

Autosymmetric functions exhibit a special type of regularity that can speed-up the minimization process. Based on this autosymmetry, we propose a three level form of logic synthesis, called ORAX (EXOR-AND-OR), to be compared with the standard minimal SOP (Sum of Products) form. First we provide a fast ORAX minimization algorithm for autosymmetric functions. The ORAX network for a function f has a first level of at most 2(n−k) EXOR gates, followed by the AND-OR levels, where n is the number of input variables and k is the “autosymmetry degree” of f. In general a minimal ORAX form has smaller size than a standard minimal SOP form for the same function. We show how the gain in area of ORAX over SOP can be measured without explicitly generating the latter. If preferred, a SOP expression can be directly derived from the corresponding ORAX. A set of experimental results confirms that the ORAX form is generally more compact than the SOP form, and its synthesis is much faster than classical three-level logic minimization. Indeed ORAX and SOP minimization times are often comparable, and in some cases ORAX synthesis is even faster.     

Urinary leukotriene E4 and 11-dehydrothromboxane B2 in patients with aspirin-sensitive asthma

The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane A2 in the pathogenesis of aspirin-sensitive asthma (ASA). Leukotriene E4 (LTE4) and 11-dehydrothromboxane B2 (11DTXB2) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history (non-aspirin-sensitive asthma [NASA]) in the outpatient clinic. The urinary LTE4 value was significantly higher in ASA patients than in NASA (340 +/- 47 vs 65 +/- 15 pg/mg.cr, P < 0.001), but there was no significant difference in urinary 11DTXB2 between the two groups (891 +/- 77 vs 657 +/- 90 pg/mg.cr). A high value of LTE4 was not associated with type of asthma, severity of disease, oral prednisolone treatment, sex, or age. A higher value of 11DTXB2 was observed in the atopic type than the nonatopic type in ASA (1086 +/- 111 vs 697 +/- 147 pg/mg.cr, P < 0.05). No correlation was observed between urinary LTE4 and 11DTXB2 in either ASA or NASA. In conclusion, LTs may play an important role in the pathogenesis of ASA, and TXA2 in the pathogenesis of the atopic type in ASA.     

Microwave assisted combustion synthesis in the system Ti–Si–C for the joining of SiC: Experimental and numerical simulation results

Microwaves at 2.45 GHz have been applied to ignite the combustion synthesis of compacted Ti–Si–C powders mixtures, having 1:1:1 atomic ratio, in order to join SiC-based components. A mixture of different refractory phases such as TiC and TiSi₂ were obtained. Depending on the synthesis conditions, no residual silicon in the joint was detected, suggesting the suitability of the here proposed experimental joining approach for nuclear plants and high temperature applications. A simplified model was developed with the aim of obtaining a deeper understanding of the here proposed rapid, almost pressure-less and localized heating joining method. Experimental and numerical simulation results demonstrate that joining of SiC can be rapidly obtained with minimization of heat affected zones in the SiC substrates. Maximum apparent shear strength values of the joints ranged from 9.9 to 45.1 MPa, depending on the process conditions.     

Effect of the Phase Composition of Barium-Calcium Alumoscandates on the Emission Properties of Impregnated Cathodes

The effect of scandium oxide additions on the emission properties of impregnated tungsten cathodes was investigated. The synthesis of alumoscandates in the BaO ― CaO ― Sc₂O₃ ― Al₂O₃ system were studied by x-ray diffraction, thermography, and petrographic analysis. The hygroscopic properties of the emission-active material was determined. Based on the results of emission tests the recommended optimal compositions of emission-active material are 2.4 BaO·0.6 CaO·0.1 Sc₂O₃·0.9 Al₂O₃ and 2.6 BaO·1.9 CaO·0.1 Sc₂O₃·0.9 Al₂O₃. Cathodes based on these compositions had lifetimes greater than 10000 h operating in the temperature range 900-1000°C at current densities of 15-20 A/cm² in a vacuum of the order of 10⁻⁶ Torr.

     

Mechanism of welding fume suppression during AC-pulsed MIG welding of Al-Mg alloys

Welding fume, inevitably generated during arc welding processes, may be a source of occupational pneumoconiosis when persistently inhaled in the long term and accordingly merits serious consideration in occupational hygiene respects. To improve the working environment at welding sites, it is imperative to ensure total air exchange at work sites, local extraction in the vicinity of welding facilities, and the wearing of respiration protection devices in other respects.¹ Currently available preventive measures, however, suffer from a number of drawbacks, such as heavy investments needing to be made in equipment and facilities and operability being obstructed by the wearing of respiration protection devices. Alongside such passive measures, it is desirable to develop welding materials or methods able to suppress welding fume generation at source.     

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

HIV‐1 integrase (IN) active site inhibitors are the latest class of drugs approved for HIV treatment. The selection of IN strand‐transfer drug‐resistant HIV strains in patients supports the development of new agents that are active as allosteric IN inhibitors. Here, a docking‐based virtual screening has been applied to a small library of natural ligands to identify new allosteric IN inhibitors that target the sucrose binding pocket. From theoretical studies, kuwanon‐L emerged as the most promising binder and was thus selected for biological studies. Biochemical studies showed that kuwanon‐L is able to inhibit the HIV‐1 IN catalytic activity in the absence and in the presence of LEDGF/p75 protein, the IN dimerization, and the IN/LEDGF binding. Kuwanon‐L also inhibited HIV‐1 replication in cell cultures. Overall, docking and biochemical results suggest that kuwanon‐L binds to an allosteric binding pocket and can be considered an attractive lead for the development of new allosteric IN antiviral agents.     

An effective multipurpose building block for 3D electropolymerisation: 2,2′-Bis(2,2′-bithiophene-5-yl)-3,3′-bithianaphthene

Novel thiophene-based oligomer, 2,2′-bis(2,2′-bithiophene-5-yl)-3,3′-bithianaphthene (TX), was designed and synthesized, and its electrochemical and spectral properties characterised. TX was readily polymerised electrochemically to form well organized conducting homopolymer films on various solid electrode substrates. Moreover, it was successfully used for deposition by electropolymerisation of electrochemically active thin films of co-polymers with three different monomers of functionalised bis(2,2′-bithienyl)methane derivatives. It appeared that TX was an effective crosslinker and 3D promoter in these electropolymerisations involving co-monomers intrinsically showing limited aptitude for the electropolymerisation or forming polymer films of low conductivity. This attractive TX ability stems from combination of its (i) high conjugation efficiency in each of the two planar moieties, (ii) intrinsic 3D structure on account of the presence of the central node, and (iii) intrinsic regioselectivity in electropolymerisation on account of the positions of the two available free α-thiophene sites.