基于AT89C52单片机的步进电机控制系统研究

本文介绍了基于AT89C52单片机的两相混合式步进电机控制系统的设计方案,增加了步进电机控制系统设计的灵活性。控制系统采用AT89C52单片机作为控制器,由达林顿功率管BUW49组成的双H桥式电路作为驱动器,加入按键控制及LCD1602显示。控制系统的电路结构简单、设计思路清晰。实验表明,控制系统操作简单、运行可靠,具有较强的实用性。     

基于小波变换的暂态电能质量扰动检测与定位研究

本文深入探讨了暂态电能质量扰动检测与定位的小波变换方法。首先,分析了小波变换的基本原理及其快速计算的多分辨率方法,然后研究了小波变换极值与信号突变、噪声的相关性,在此基础上,详细阐述了应用小波变换进行暂态电能质量扰动检测与定位的原理过程,最后,运用Matlab软件进行了计算机仿真,给出了各种态电能质量扰动检测与定位检测与定位的仿真结果。理论分析和仿真结果显示应用小波变化对暂态电能质量扰动进行检测和定位,具有精确、实时、易实现等优点,是一种较理想的暂态电能质量扰动检测与定位方法。     

压缩系统对温度突升响应的动态分析

基于时间滞后概念,建立了压缩系统动态响应分析的通用模型,并对温度突升条件下多级轴流压缩系统的动态响应及气动稳定性进行了详细的数值分析。对两个算例的分析,结果表明了本文新模型的可行性。     

Specific Local Predictors That Reflect the Tropism of Endometriosis—A Multiple Immunohistochemistry Technique

Ectopic endometrial epithelium associates a wide spectrum of symptomatology. Their evolution can be influenced by inflammatory and vascular changes, that affect not only the structure and cell proliferation rate, but also symptoms. This prospective study involved tissue samples from surgically treated patients, stained using classical histotechniques and immunohistochemistry. We assessed ectopic endometrial glands (CK7+, CK20−), adjacent blood vessels (CD34+), estrogen/progesterone hormone receptors (ER+, PR+), inflammatory cells (CD3+, CD20+, CD68+, Tryptase+), rate of inflammatory cells (Ki67+) and oncoproteins (BCL2+, PTEN+, p53+) involved in the development of endometriosis/adenomyosis. A CK7+/CK20− expression profile was present in the ectopic epithelium and differentiated it from digestive metastases. ER+/PR+ were present in all cases analyzed. We found an increased vascularity (CD34+) in the areas with abdominal endometriosis and CD3+−:T-lymphocytes, CD20+−:B-lymphocytes, CD68+:macrophages, and Tryptase+: mastocytes were abundant, especially in cases with adenomyosis as a marker of proinflammatory microenvironment. In addition, we found a significantly higher division index-(Ki67+) in the areas with adenomyosis, and inactivation of tumor suppressor genes-p53+ in areas with neoplastic changes. The inflammatory/vascular/hormonal mechanisms trigger endometriosis progression and neoplastic changes increasing local pain. Furthermore, they may represent future therapeutic targets. Simultaneous-multiple immunohistochemical labelling represents a valuable technique for rapidly detecting cellular features that facilitate comparative analysis of the studied predictors.     

Structural Abnormalities of the Optic Nerve and Retina in Huntington’s Disease Pre-Clinical and Clinical Settings

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. HD-related pathological remodelling has been reported in HD mouse models and HD carriers. In this study, we studied structural abnormalities in the optic nerve by employing Spectral Domain Optical Coherence Tomography (SD-OCT) in pre-symptomatic HD carriers of Caucasian origin. Transmission Electron Microscopy (TEM) was used to investigate ultrastructural changes in the optic nerve of the well-established R6/2 mouse model at the symptomatic stage of the disease. We found that pre-symptomatic HD carriers displayed a significant reduction in the retinal nerve fibre layer (RNFL) thickness, including specific quadrants: superior, inferior and temporal, but not nasal. There were no other significant irregularities in the GCC layer, at the macula level and in the optic disc morphology. The ultrastructural analysis of the optic nerve in R6/2 mice revealed a significant thinning of the myelin sheaths, with a lamellar separation of the myelin, and a presence of myelonoid bodies. We also found a significant reduction in the thickness of myelin sheaths in peripheral nerves within the choroids area. Those ultrastructural abnormalities were also observed in HD photoreceptor cells that contained severely damaged membrane disks, with evident vacuolisation and swelling. Moreover, the outer segment of retinal layers showed a progressive disintegration. Our study explored structural changes of the optic nerve in pre- and clinical settings and opens new avenues for the potential development of biomarkers that would be of great interest in HD gene therapies.     

单模光纤环轴向磁场问题的理论研究

去偏光纤陀螺的非理想单模光纤,在垂直于光纤环面的轴向磁场作用下,由于Faraday 效应,在其中传播的正反两束光会产生一个与磁场有关的非互易相位差.本文基于单色光对在轴向磁场作用下的单模光纤环进行理论推导、分析,给出仿真结果和实验结果,并提出减小轴向磁场作用下的Faraday非互易相位差的方法.     

Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers

Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely available, relatively cheap medications. They also have the ability to modulate the membrane components of tumor cells. The aim of this review is to analyze the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid and paracetamol on skin and gastrointestinal cancers cell membrane. These drugs may affect the membrane through topical application, at the in vitro and in vivo level after oral or parenteral administration. They can lead to up- or downregulated expression of receptors, transporters and other molecules associated with plasma membrane. Medications may also alter the lipid bilayer composition of membrane, resulting in changes in its integrity and fluidity. Described modulations can cause the visualization of cancer cells, enhanced response of the immune system and the initiation of cell death. The outcome of this is inhibition of progression or reduction of tumor mass and supports chemotherapy. In conclusion, non-opioid analgesics may be used in the future as adjunctive therapy for the treatment of these cancers.     

Determination of L3 subshell X-ray production cross-sections and fluorescence yields of Pb, Th and U

A study of L₃ subshell X-ray production cross-sections and fluorescence yields by using characteristic K X-rays as the exciting radiation is described. Only the L₃ subshells of Pb, Th and U were excited by the characteristic K X-rays of the elements used as secondary sources. The cross-sections for the production of L_l, L and L_β groups of L₃ subshell X-rays of Pb, Th and U have been measured using photoionization by Rb, Nb and Mo K X-rays. The measured L₃ X-ray production cross-section values for Pb, Th and U are in good agreement with the theoretical ones evaluated using L₃ subshell fluorescence yield ω₃, fractions of the radiative width F_3i and L₃ subshell photoionization cross-section σ₃. The L₃ subshell fluorescence yields (ω₃) have also been computed using the presently measured cross-section values and the theoretical L₃ subshell photoionization cross-section values. These results are compared with the theoretically predicted values.     

Transport of electrons in a GaAs quantum well in high electric fields

The rates of intrasubband and intersubband scattering of electrons by polar optical and intervalley phonons are determined in relation to the electron energy and width of a deep rectangular quantum well in GaAs. The Monte Carlo method was used to calculate the field dependences of the electron’s drift velocity in quantum wells with the width of 10, 20, and 30 nm. It is shown that the drift velocity in high electric fields in a quantum well vastly exceeds the maximum drift’s saturation velocity in the bulk material.