非自衡对象的预测控制

DMC在对非自衡对象建模时会产生截断误差,因此无法直接用于该类对象控制．根据非自衡对象阶跃响应的最后阶段可视为直线的特点,提出了一种基于对象阶跃响应的参数化模型的预测控制算法,该算法避免了DMC预测模型的截断误差影响．仿真结果表明,提出的算法对于设定值变化具有良好的跟踪性,对于模型参数的摄动具有良好的鲁棒性,该算法对于非自衡对象控制是有效的．     

基于消息的单片机多任务编程

将Windows环境下多任务编程思想引入单片机控制系统，在单片机领域引入消息的概念，介绍了单片机控制系统中消息的产生、响应过程，提出并阐述了在单片机控制系统基于消息的多任务编程机制。     

CNC机床加工螺旋锥齿轮的展成原理分析

概述了螺旋锥齿轮加工技术的国内外概况，以矢量为工具推导了Oerlikon C系列CNC机床加工螺旋锥齿轮的展成齿面方程，为机床理论加工参数和实际加工参数的确定打下了基础。     

新型固态故障限流器的仿真研究

介绍了新型固态故障限流器 ( solid- state fault current limiter SSFCL)的基本原理和运行特点 ,并就浙江省北仑发电厂一号机组系统中 5 0 0 k V高压母线进行了仿真研究 .利用电力系统仿真软件 NETOMAC分别模拟、计算并输出了当该系统发生短路故障时 ,系统故障处没有采取限流措施及应用了 SSFCL情况下的电磁暂态过程 ,再对之进行仔细的比较和分析 .仿真结果证明 ,当系统发生短路故障时 ,通过 SSFCL快速而有效的限流作用 ,可以很好地改善该系统的电能质量 .最后 ,还提供了应用的 SSFCL中各电力电子器件的额定参数值 .     

Near infrared light-induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol

Light-sensitive drug delivery systems are considered ideal for applications in the biomedical fields for their ability to release the payload in an on-demand spatiotemporal controlled manner through the manipulation of the light source. Among the broad radiation spectrum, near infrared (NIR) light is considered advantageous compared to UV and visible light, due to its inherently lower photodamage to normal tissues and deeper penetration to lesion areas. In this study, we report a successful synthesis of a polymer capable of undergoing partial degradation upon irradiation with NIR light by conjugating 10-N-carbamoyl linkage methylene blue (MB) moiety, a NIR photocleavable ligand, with polyethylene glycol (PEG). Through effective coupling of MB, a hydrophobic moiety, to the hydrophilic PEG molecule, an amphiphilic polymer was synthesized, as demonstrated by a lowered surface tension (55 mN/m at 0.1% wt/vol). Subsequently, photo-induced reversal of surface activity associated with self-assembled structure disruption, was displayed by surface tension measurements, size distribution analysis, and burst release profile of paclitaxel (PTX) from polymeric micelles upon the exposure to NIR irradiation.     

Optimization of Blood Handling and Peripheral Blood Mononuclear Cell Cryopreservation of Low Cell Number Samples

Background: Rural/remote blood collection can cause delays in processing, reducing PBMC number, viability, cell composition and function. To mitigate these impacts, blood was stored at 4 °C prior to processing. Viable cell number, viability, immune phenotype, and Interferon-γ (IFN-γ) release were measured. Furthermore, the lowest protective volume of cryopreservation media and cell concentration was investigated. Methods: Blood from 10 individuals was stored for up to 10 days. Flow cytometry and IFN-γ ELISPOT were used to measure immune phenotype and function on thawed PBMC. Additionally, PBMC were cryopreserved in volumes ranging from 500 µL to 25 µL and concentration from 10 × 10⁶ cells/mL to 1.67 × 10⁶ cells/mL. Results: PBMC viability and viable cell number significantly reduced over time compared with samples processed immediately, except when stored for 24 h at RT. Monocytes and NK cells significantly reduced over time regardless of storage temperature. Samples with >24 h of RT storage had an increased proportion in Low-Density Neutrophils and T cells compared with samples stored at 4 °C. IFN-γ release was reduced after 24 h of storage, however not in samples stored at 4 °C for >24 h. The lowest protective volume identified was 150 µL with the lowest density of 6.67 × 10⁶ cells/mL. Conclusion: A sample delay of 24 h at RT does not impact the viability and total viable cell numbers. When long-term delays exist (>4 d) total viable cell number and cell viability losses are reduced in samples stored at 4 °C. Immune phenotype and function are slightly altered after 24 h of storage, further impacts of storage are reduced in samples stored at 4 °C.     

Identification of para‐Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot

Slingshot proteins form a small group of dual‐specific phosphatases that modulate cytoskeleton dynamics through dephosphorylation of cofilin and Lim kinases (LIMK). Small chemical compounds with Slingshot‐inhibiting activities have therapeutic potential against cancers or infectious diseases. However, only a few Slingshot inhibitors have been investigated and reported, and their cellular activities have not been examined. In this study, we identified two rhodanine‐scaffold‐based para‐substituted benzoic acid derivatives as competitive Slingshot inhibitors. The top compound, (Z)‐4‐((4‐((4‐oxo‐2‐thioxo‐3‐(o‐tolyl)thiazolidin‐5‐ylidene)methyl)phenoxy)methyl)benzoic acid ( D3 ) had an inhibition constant (K_i) of around 4 μm and displayed selectivity over a panel of other phosphatases. Moreover, compound D3 inhibited cell migration and cofilin dephosphorylation after nerve growth factor (NGF) or angiotensin II stimulation. Therefore, our newly identified Slingshot inhibitors provide a starting point for developing Slingshot‐targeted therapies.     

High-efficiency Silicon Solar Cells: A Review

Over the past few decades, crystalline silicon solar cells have been extensively studied due to their high efficiency, high reliability, and low cost. In addition, these types of cells lead the industry and account for more than half of the market. For the foreseeable future, Si will still be a critical material for photovoltaic devices in the solar cell industry. In this paper, we discuss key issues, cell concepts, and the status of recent high-efficiency crystalline silicon solar cells.     

Markov-Based Lane Positioning Using Intervehicle Communication

The majority of today's navigation techniques for intelligent transportation systems use global positioning systems (GPS) that can provide position information with bounded errors. However, due to the low accuracy that is experienced with standard GPS, it is difficult to determine a vehicle's position at lane level. Using a Markov-based approach based on sharing information among a group of vehicles that are traveling within communication range, the lane positions of vehicles can be found. The algorithm's effectiveness is shown in both simulations and experiments with real data.     

基于接触的水下夹桩器压块齿非线性有限元分析

水下夹桩器是一种广泛应用于海洋石油平台建设的液压夹具。基于扩展的拉格朗日算法,使用ANSYS软件对钢桩和夹桩器压块齿的接触问题进行了数值模拟受力分析,获得压块齿实际工况下的接触压力及其挤压变形等结果。并将该结果与理论计算结果进行了比较,计算结果满足工程要求。分析结果显示,将有限元接触分析技术应用于水下夹桩器压块齿的设计是一种有效的方法,为水下夹桩器压块齿结构进一步改进,提供了理论依据。