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51.
52.
Patrícia Libório Vinicius A. Oliveira 《Polymer-Plastics Technology and Engineering》2017,56(2):123-130
Bentonite was modified with trialkylaluminum to prepare polypropylene/clay nanocomposites. Treated clay, commercial polypropylene, and a coupling agent were mixed in miniextruder. To obtain the masterbatches and dilutions, two polypropylene grades were used to analyze the influence of molar mass on clay dispersion. The screw rotation varied from 30 to 200?rpm, and the clay content was 1, 2, and 5?wt%. For samples prepared with higher molar mass, increasing speed from 30 to 200?rpm improved the clay dispersion. For processing with lower molar mass, decreasing speed from 60 to 30?rpm caused an increase in viscosity, resulting in better dispersion. 相似文献
53.
Structure–Activity Relationships of Benzenesulfonamide‐Based Inhibitors towards Carbonic Anhydrase Isoform Specificity
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Avni Bhatt Dr. Brian P. Mahon Vinicius Wilian D. Cruzeiro Dr. Benedetta Cornelio Dr. Marie Laronze‐Cochard Dr. Mariangela Ceruso Prof. Dr. Janos Sapi Dr. Graham A. Rance Prof. Dr. Andrei N. Khlobystov Assoc. Prof. Dr. Antonella Fontana Prof. Dr. Adrian Roitberg Prof. Dr. Claudiu T. Supuran Prof. Dr. Robert McKenna 《Chembiochem : a European journal of chemical biology》2017,18(2):213-222
Carbonic anhydrases (CAs) are implicated in a wide range of diseases, including the upregulation of isoforms CA IX and XII in many aggressive cancers. However, effective inhibition of disease‐implicated CAs should minimally affect the ubiquitously expressed isoforms, including CA I and II, to improve directed distribution of the inhibitors to the cancer‐associated isoforms and reduce side effects. Four benzenesulfonamide‐based inhibitors were synthesized by using the tail approach and displayed nanomolar affinities for several CA isoforms. The crystal structures of the inhibitors bound to a CA IX mimic and CA II are presented. Further in silico modeling was performed with the inhibitors docked into CA I and XII to identify residues that contributed to or hindered their binding interactions. These structural studies demonstrated that active‐site residues lining the hydrophobic pocket, especially positions 92 and 131, dictate the positional binding and affinity of inhibitors, whereas the tail groups modulate CA isoform specificity. Geometry optimizations were performed on each ligand in the crystal structures and showed that the energetic penalties of the inhibitor conformations were negligible compared to the gains from active‐site interactions. These studies further our understanding of obtaining isoform specificity when designing small molecule CA inhibitors. 相似文献
54.
Thorns and dermal denticles of skates Atlantoraja cyclophora and A. castelnaui: Microscopic features and functional implications
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Bianca de Sousa Rangel Natascha Wosnick Rafael Magdanelo Leandro Alberto Ferreira de Amorim José Roberto Kfoury Junior Rose Eli Grassi Rici 《Microscopy research and technique》2016,79(12):1133-1138
Some batoid species are covered with dermal denticles (or placoid scales) that occasionally develop into thorns. In sexually mature males, sharp teeth and alar thorns found on the apex of the lateral disc are used to hold the female during copulation. This study set out to analyze microscopic features of modified dermal denticles and thorns and to investigate sexual dimorphism in Atlantoraja cyclophora and A. castelnaui species. Skin samples collected from areas covered with thorns were fixed in 10% formaldehyde, processed and analyzed using scanning electron microscopy. Alar thorn morphology varied within species, while caudal thorn, rostral and caudal dermal denticle morphology varied within and between species. These structures play an important role in the protection and reproduction of the species studied and constitute important taxonomic information, given they are often the only elements preserved in archaeological sites and fossil records. 相似文献
55.
Nunes TG Polido M Amorim A Nunes SG Toledano M 《Journal of materials science. Materials in medicine》2007,18(10):2093-2099
This study presents evidence at molecular level for the chemical interaction between human dentin from different tooth regions
and a monomer with phosphate groups, incorporated in the formulation of a simplified adhesive system. Because dentin was observed
as a powder, previous verification was obtained for an eventual collagen denaturation due to the grinding process. The presence
of chemical bonds involving coronal (CD) or radicular dentin (RD) was investigated using multinuclear magnetic resonance (MR)
techniques. Narrow signals were identified in the carbon magic angle spinning (MAS) spectra of CD and RD treated with the
adhesive, which were assigned to methylenic groups in methacryloyloxydecyl dihydrogen phosphate (MDP) bound to hydroxyapatite
Ca2+; 1H spectra of the adhesive components and treated dentin, in ethanol, support this conclusion. 31P MAS spectra obtained from both dentin regions present additional shielding and broadening effects subsequent to application
and photopolymerization of the adhesive, which were higher for CD. Multinuclear MR studies provided evidence for the interaction
of the adhesive with dentin, which involves hydroxyapatite and is stronger for CD than for RD, but no direct proof was obtained
on bonding to collagen. 相似文献
56.
Divacancies in graphene and carbon nanotubes 总被引:1,自引:0,他引:1
Divacancies are among the most important defects that alter the charge transport properties of single-walled carbon nanotubes (SWNT), and we here study, using ab initio calculations, their properties. Two structures were investigated, one that has two pentagons side by side with an octagon (585) and another composed of three pentagons and three heptagons (555777). We investigate their stability as a function of tube diameter, and calculate their charge transport properties. The 585 defect is less stable in graphene due to two broken bonds in the pentagons. We estimate that the 555777 becomes more stable than the 585 for a diameter of about 40 A (53 A) for an armchair (zigzag) SWNTs, indicating that they will prevail in large diameter multiwalled carbon nanotubes and graphene ribbons. 相似文献
57.
D. S. Morais M. A. Rodrigues M. A. Lopes M. J. Coelho A. C. Maurício R. Gomes I. Amorim M. P. Ferraz J. D. Santos C. M. Botelho 《Journal of materials science. Materials in medicine》2013,24(9):2145-2155
A novel hydrogel, based on an alginate/hyaluronate mixture and Ce(III) ions, with effective bioactive and antimicrobial ability was developed to be used as vehicle of a synthetic bone substitute producing an injectable substitute (IBS). Firstly, three different IBSs were prepared using three developed alginate-based hydrogels, the hydrogel Alg composed by alginate, the hydrogel Alg/Ch composed by an alginate/chitosan mixture and the hydrogel Alg/HA composed by an alginate/hyaluronate mixture. MG63 cells viability on the IBSs was evaluated, being observed a significantly higher cell viability on the Alg/HA_IBS at all time points, which indicates a better cell adaptation to the material, increasing their predisposition to produce extracellular matrix and thus allowing a better bone regeneration. Moreover, SEM analysis showed evident filopodia and a spreader shape of MG63 cells when seeded on Alg/HA_IBS. This way, based upon the in vitro results, the hydrogel Alg/HA was chosen to the in vivo study by subcutaneous implantation in an animal model, promoting a slight irritating tissue response and visible tissue repairing. The next step was to grant antimicrobial properties to the hydrogel that showed the best biological behavior by incorporation of Ce(III) ions into the Alg/HA, producing the hydrogel Alg/HA2. The antimicrobial activity of these hyaluronate-based hydrogels was evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans. Results showed that Ce(III) ions can significantly enhance the hydrogel antimicrobial ability without compromising the osteoconductivity improvement promoted by the vehicle association to the synthetic bone substitute. 相似文献
58.
A. V. Machado S. Amorim G. Botelho I. C. Neves A. M. Fonseca 《Journal of Materials Science》2013,48(9):3578-3585
Organic–inorganic hybrid nanocomposites were prepared via in situ sol–gel process. The organic phase is a biodegradable polymer, poly(ε-caprolactone) (PCL), while the tetrabutyl titanate (TBT, Ti(OBu)4) was used as inorganic precursor. Synthesis parameters like acidity medium and precursor amount were investigated in order to assess their influence on hybrid properties. The obtained nanocomposites were characterised by thermal analysis, spectroscopic techniques, transmission electronic microscopy (TEM) and X-ray diffraction to gather information on the structure of the nanocomposites. Mechanical properties and biodegradability were also evaluated. A reaction mechanism based on Fourier transform infrared spectroscopy and NMR results was proposed using methyl acetate as model compound. TEM micrographs of the nanocomposites show a fine good nanoparticles dispersion. Acidic conditions and 10 wt% of precursor lead to a nanocomposite with higher mechanical properties and biodegradability than PCL. 相似文献
59.
To minimize the detrimental effects of zinc during resistance spot welding of galvanized plates, a technique known as Burn-Zinc is usually employed. However, there is not much information and studies available in the current literature about when and how to use this technique. The objective of this paper is to assess and understand this technique. To do so, a methodology to determine the ideal burn-zinc parameters as a function of the plates was proposed. This methodology was evaluated by a series of welds by systematically varying current and pressure at compatible levels for zinc burning. High-speed filming, synchronized with electrical signals, was employed to visualize and to analyse results. Once the burn-zinc parameters were defined, new welds were performed with and without the burn-zinc application. The proposed experimental procedure was shown to be efficient for checking and parametrizing the burn-zinc technique. However, there was evidence that the application of burn-zinc does not always lead to a reduction in operating time. 相似文献
60.
Annelise Kopp Alves Felipe Amorim Berutti Carlos Pérez Bergmann 《Particulate Science and Technology》2013,31(4):351-360
ABSTRACT This article describes the effects of pH on the preparation and properties of aluminas (A l 2 O 3) produced by the sol-gel colloidal method. The precursor, hexahydrated aluminum chloride, was subjected to peptization reactions giving rise to a viscous gel with amorphous characteristics. Calcination at temperatures about 1000°C caused this gel to transform into alumina products with different morphologies, such as powders, fibers, or porous ceramic bodies, depending on the process parameters adopted, such as the pH and the drying conditions. These products were characterized according to their particle size distribution, thermogravimetry and differential thermal analysis (TG/DTA), and X-ray diffraction (XRD), and their morphologies were analyzed by scanning electron microscopy (SEM). 相似文献