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排序方式: 共有1149条查询结果,搜索用时 15 毫秒
51.
Phase behaviour modelling of reservoir fluid is a fundamental step for reservoir simulation. Furthermore, as the complexity of the recovery process increases, the fluid model plays a more important role in the reliability of the simulation outputs. Although the in situ combustion enhanced oil recovery method (ISC) is one of the most complex recovery techniques available in the petroleum engineering literature, for most of the simulation jobs related to this elaborate process only simple and rudimentary fluid characterization layouts are considered. In this work, the principal fluid properties of Athabasca bitumen with regard to the ISC process are recognized, extracted from the literature, validated for consistency, and used for the development of an inclusive and accurate fluid model. Then the fluid model is fully developed while considering the ISC reaction kinetics so that the model has both accuracy, indispensable for phase behaviour modelling, and consistency, essential for the reactions definitions. 相似文献
52.
Chinh Ngo Radhika Mehta Kanchan Aggarwal Audrey G. Fikes Dr. Ines C. Santos Dr. Sylvester M. Greer Prof. Dr. Emily L. Que 《Chembiochem : a European journal of chemical biology》2019,20(8):1003-1007
One-third of all proteins are estimated to require metals for structural stability and/or catalytic activity. Desthiobiotin probes containing metal binding groups can be used to capture metalloproteins with exposed active-site metals under mild conditions so as to prevent changes in metallation state. The proof-of-concept was demonstrated with carbonic anhydrase (CA), an open active site, Zn2+-containing protein. CA was targeted by using sulfonamide derivatives. Linkers of various lengths and structures were screened to determine the optimal structure for capture of the native protein. The optimized probes could selectively pull down CA from red blood cell lysate and other protein mixtures. Pull-down of differently metallated CAs was also investigated. 相似文献
53.
The thermal degradation of foamed polymethyl methacrylate (PMMA) patterns in the expendable pat-tern casting process has been
studied. Various physical transitions that may occur during the degradation of PMMA have been determined using scanning electron
microscopy, differential scanning calorimetry, and thermogravimetric analysis, and the effects of polymer density on the degradation
characteristics have been investigated. The results indicate that, when exposed to elevated temperatures, the polymer beads
collapse at about 140 to 200 °. The collapsed beads melt at 260 ° and begin to volatilize. Peak volatilization temperatures
are on the order of 370 °. The end temperature for volatilization is between 420 and 430 °. The initial density of the polymer
does not have a significant effect on the transition tem-peratures associated with degradation. 相似文献
54.
ABSTRACTFeature selection is an important task to improve the classifier’s accuracy and to decrease the problem size. A number of methodologies have been presented for feature selection problems using metaheuristic algorithms. In this paper, an improved self-adaptive inertia weight particle swarm optimisation with local search and combined with C4.5 classifiers for feature selection algorithm is proposed. In this proposed algorithm, the gradient base local search with its capacity of helping to explore the feature space and an improved self-adaptive inertia weight particle swarm optimisation with its ability to converge a best global solution in the search space. Experimental results have verified that the SIW-APSO-LS performed well compared with other state of art feature selection techniques on a suit of 16 standard data sets. 相似文献
55.
56.
Kasper P. Lundquist Dr. Vipul Panchal Prof. Charlotte H. Gotfredsen Prof. Ruth Brenk Prof. Mads H. Clausen 《ChemMedChem》2021,16(17):2588-2603
Rapid development within the fields of both fragment-based drug discovery (FBDD) and medicinal targeting of RNA provides possibilities for combining technologies and methods in novel ways. This review provides an overview of fragment-based screening (FBS) against RNA targets, including a discussion of the most recently used screening and hit validation methods such as NMR spectroscopy, X-ray crystallography, and virtual screening methods. A discussion of fragment library design based on research from small-molecule RNA binders provides an overview on both the currently limited guidelines within RNA-targeting fragment library design, and future possibilities. Finally, future perspectives are provided on screening and hit validation methods not yet used in combination with both fragment screening and RNA targets. 相似文献
57.
The stretchable electrodes with excellent flexibility, electrical conductivity, and mechanical durability are the most fundamental components in the emerging and exciting field of flexible electronics. This article proposes a method for fabrication of such a stretchable electrode by embedding silver nanorods (AgNRs) into a polydimethylsiloxane (PDMS) matrix that is grown by a unique glancing angle deposition technique. The surface, mechanical, and electrical properties of PDMS are significantly changed after embedding the AgNRs in it. The results show that surface roughness and polarity increase after AgNRs are embedded in the PDMS matrix. Elastic modulus (E) and hardness (H) decrease with an increase in the indentation load as a result of the indentation depth effect. Due to strong interfacial adhesion of AgNRs embedded in the PDMS matrix, the E and H of nanocomposite are increased by 167.6 and 93.3% compared with PDMS film, respectively. Furthermore, the AgNRs-PDMS film has an electrical resistivity value in the order of 10−7 Ωm. It remains conductive during various mechanical strains such as bending, twisting, and stretching, which is demonstrated using a light-emitting diode circuit. Simultaneously, the antimicrobial activity of silver could make it a promising candidate for wearable electronics. 相似文献
58.
Mehta DS Sugai M Hinosugi H Saito S Takeda M Kurokawa T Takahashi H Ando M Shishido M Yoshizawa T 《Applied optics》2002,41(19):3874-3885
A noncontact, nonmechanical scanning, wide-field spectral interference microscope is developed for simultaneous measurement of three-dimensional step-height of discontinuous objects and tomographic imaging. A superluminescent diode (SLD) is used as a broadband light source and a liquid-crystal Fabry-Perot interferometer (LC-FPI) as a frequency-scanning device. By means of changing the injection current to the SLD, the spectral profile of the SLD is equalized, and a constant light input to the interferometer is achieved over the entire frequency-scan range. The Fourier-transform technique is used to determine both the amplitude and the phase of spectral fringe signals. Three-dimensional height distribution of a discontinuous object is obtained from the phase information, whereas optically sectioned images of the object are obtained either from the amplitude information alone or from the combination of both the amplitude and phase information. Experimental results with submicrometer resolution are presented for both step-height measurement and tomographic sectioning. 相似文献
59.
Guido Berning Marcus Brandenburg Korhan Gürsoy Vipul Mehta Franz-Josef Tölle 《OR Spectrum》2002,24(4):371-401
This paper considers a complex scheduling problem in the chemical process industry involving batch production. The application
described comprises a network of production plants with interdependent production schedules, multi-stage production at multi-purpose
facilities, and chain production. The paper addresses three distinct aspects: (i) a scheduling solution obtained from a genetic algorithm based optimizer, (ii) a mechanism for collaborative planning among the involved plants, and (iii) a tool for manual updates and schedule changes. The tailor made optimization algorithm simultaneously considers alternative
production paths and facility selection as well as product and resource specific parameters such as batch sizes, and setup
and cleanup times. The collaborative planning concept allows all the plants to work simultaneously as partners in a supply
chain resulting in higher transparency, greater flexibility, and reduced response time as a whole. The user interface supports
monitoring production schedules graphically and provides custom-built utilities for manual changes to the production schedule,
investigation of various what-if scenarios, and marketing queries.
RID="*"
ID="*" The authors would like to thank Hans-Otto Günther and Roland Heilmann for helpful comments on draft versions of this
paper. 相似文献
60.
Secure and mobile networking 总被引:2,自引:0,他引:2
The IETF Mobile IP protocol is a significant step towards enabling nomadic Internet users. It allows a mobile node to maintain
and use the same IP address even as it changes its point of attachment to the Internet. Mobility implies higher security risks
than static operation. Portable devices may be stolen or their traffic may, at times, pass through links with questionable
security characteristics. Most commercial organizations use some combination of source-filtering routers, sophisticated firewalls,
and private address spaces to protect their network from unauthorized users. The basic Mobile IP protocol fails in the presence
of these mechanisms even for authorized users. This paper describes enhancements that enable Mobile IP operation in such environments,
i.e., they allow a mobile user, out on a public portion of the Internet, to maintain a secure virtual presence within his
firewall-protected office network. This constitutes what we call a Mobile Virtual Private Network (MVPN).
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献